Rapid Synthesis of Bradykinin in Solution

Two variants of the two-phase-purification method are examined, using the preparation of bradykinin as a model. In one synthesis, intermediate purification by liquid-liquid extraction was carried out after each completed elongation, in the other, new variant, the extractions were performed after th...

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Bibliographic Details
Main Authors: Hanspeter Rolli, Conrad H. Schneider
Format: Article
Language:deu
Published: Swiss Chemical Society 1981-10-01
Series:CHIMIA
Online Access:https://www.chimia.ch/chimia/article/view/9537
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Summary:Two variants of the two-phase-purification method are examined, using the preparation of bradykinin as a model. In one synthesis, intermediate purification by liquid-liquid extraction was carried out after each completed elongation, in the other, new variant, the extractions were performed after the deprotection steps. If not hampered by technical difficulties the second variant is more efficient.
ISSN:0009-4293
2673-2424