Attitudes and perspectives of healthcare workers on treating chronic hepatitis C infection in children and adolescents
Background and aimsThere are gaps in knowledge about the values and preferences of healthcare workers (HCW) with respect to treatment of children and adolescents living with chronic hepatitis C (HCV) infection. This study was carried out to identify these values and preferences as part of the eviden...
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Frontiers Media S.A.
2025-01-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1504678/full |
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| author | Farihah Malik Philippa Easterbrook Giuseppe Indolfi Giuseppe Indolfi Claire Thorne |
| author_facet | Farihah Malik Philippa Easterbrook Giuseppe Indolfi Giuseppe Indolfi Claire Thorne |
| author_sort | Farihah Malik |
| collection | DOAJ |
| description | Background and aimsThere are gaps in knowledge about the values and preferences of healthcare workers (HCW) with respect to treatment of children and adolescents living with chronic hepatitis C (HCV) infection. This study was carried out to identify these values and preferences as part of the evidence required to update World Health Organization (WHO) hepatitis C guidelines.MethodsAn online survey was designed and conducted during August/September 2021. Survey questions were developed to address two key questions about treatment of children and adolescents: who to treat, and which direct acting antiviral (DAA) regimens to use. The survey was circulated by the WHO to nine networks providing care to children and adolescents living with HCV infection, with respondents requested to cascade further within their networks.ResultsA total of 137 individuals from 38 countries responded to the survey. There was a trend toward higher preference for treating children of older age groups; 60% of respondents reported a strong preference for treating (i.e., stating they were very likely or likely to treat) children aged 3 to <6 years, 81 and 95% indicated strong preferences for treating those aged 6 to <12 years and 12 to <18 years, respectively. The most preferred DAA regimens for treatment across all age groups were: sofosbuvir/velpatasvir (SOF/VEL), sofosbuvir/ledipasvir (SOF/LDV), and glecaprevir/pibrentasvir (GLE/PIB). These were also reported to be the most commonly available drug regimens at respondents’ facilities.ConclusionThis survey provides insights from a heterogenous sample of HCWs from across the world with respect to their expressed priorities and preferences for the treatment of children and adolescents with chronic HCV. |
| format | Article |
| id | doaj-art-01a442b08d224b14bbdac539aca92f19 |
| institution | Kabale University |
| issn | 2296-2565 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Public Health |
| spelling | doaj-art-01a442b08d224b14bbdac539aca92f192025-01-23T05:10:20ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-01-011210.3389/fpubh.2024.15046781504678Attitudes and perspectives of healthcare workers on treating chronic hepatitis C infection in children and adolescentsFarihah Malik0Philippa Easterbrook1Giuseppe Indolfi2Giuseppe Indolfi3Claire Thorne4UCL Great Ormond Street Institute of Child Health, University College London, London, United KingdomDepartment of Global HIV, Hepatitis and STI Programmes, World Health Organization, Geneva, SwitzerlandMeyer Children’s Hospital IRCCS, Florence, ItalyDepartment Neurofarba, University of Florence, Florence, ItalyUCL Great Ormond Street Institute of Child Health, University College London, London, United KingdomBackground and aimsThere are gaps in knowledge about the values and preferences of healthcare workers (HCW) with respect to treatment of children and adolescents living with chronic hepatitis C (HCV) infection. This study was carried out to identify these values and preferences as part of the evidence required to update World Health Organization (WHO) hepatitis C guidelines.MethodsAn online survey was designed and conducted during August/September 2021. Survey questions were developed to address two key questions about treatment of children and adolescents: who to treat, and which direct acting antiviral (DAA) regimens to use. The survey was circulated by the WHO to nine networks providing care to children and adolescents living with HCV infection, with respondents requested to cascade further within their networks.ResultsA total of 137 individuals from 38 countries responded to the survey. There was a trend toward higher preference for treating children of older age groups; 60% of respondents reported a strong preference for treating (i.e., stating they were very likely or likely to treat) children aged 3 to <6 years, 81 and 95% indicated strong preferences for treating those aged 6 to <12 years and 12 to <18 years, respectively. The most preferred DAA regimens for treatment across all age groups were: sofosbuvir/velpatasvir (SOF/VEL), sofosbuvir/ledipasvir (SOF/LDV), and glecaprevir/pibrentasvir (GLE/PIB). These were also reported to be the most commonly available drug regimens at respondents’ facilities.ConclusionThis survey provides insights from a heterogenous sample of HCWs from across the world with respect to their expressed priorities and preferences for the treatment of children and adolescents with chronic HCV.https://www.frontiersin.org/articles/10.3389/fpubh.2024.1504678/fullhepatitis Cchildadolescenthealthcare workervaluespreferences |
| spellingShingle | Farihah Malik Philippa Easterbrook Giuseppe Indolfi Giuseppe Indolfi Claire Thorne Attitudes and perspectives of healthcare workers on treating chronic hepatitis C infection in children and adolescents Frontiers in Public Health hepatitis C child adolescent healthcare worker values preferences |
| title | Attitudes and perspectives of healthcare workers on treating chronic hepatitis C infection in children and adolescents |
| title_full | Attitudes and perspectives of healthcare workers on treating chronic hepatitis C infection in children and adolescents |
| title_fullStr | Attitudes and perspectives of healthcare workers on treating chronic hepatitis C infection in children and adolescents |
| title_full_unstemmed | Attitudes and perspectives of healthcare workers on treating chronic hepatitis C infection in children and adolescents |
| title_short | Attitudes and perspectives of healthcare workers on treating chronic hepatitis C infection in children and adolescents |
| title_sort | attitudes and perspectives of healthcare workers on treating chronic hepatitis c infection in children and adolescents |
| topic | hepatitis C child adolescent healthcare worker values preferences |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1504678/full |
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