Prolonged Exposure to Neonatal Hyperoxia Impairs Neuronal and Oligodendrocyte Maturation Associated with Long-Lasting Neuroinflammatory Responses in Juvenile Mice

Prolonged Exposure to Neonatal Hyperoxia Impairs Neuronal and Oligodendrocyte Maturation Associated with Long-Lasting Neuroinflammatory Responses in Juvenile Mice

Preterm infants often require oxygen supplementation, resulting in high risk for bronchopulmonary dysplasia (BPD) and neurodevelopmental deficits. Despite a growing number of studies, there is still little knowledge about brain injury in BPD models. Therefore, we exposed neonatal C57BL/6 mice to 85%...

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Bibliographic Details
Main Authors: Stefanie Obst, Meray Serdar, Karina Kempe, Dharmesh Hirani, Ursula Felderhoff-Müser, Josephine Herz, Miguel A. Alejandre Alcazar, Ivo Bendix
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Cells
Subjects:
brain injury
neuroinflammation
hyperoxia
bronchopulmonary dysplasia
delayed neural maturation
Online Access:https://www.mdpi.com/2073-4409/14/15/1141
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