Clinical features and outcomes of myelodysplastic syndrome patients with iron overload: a single-center retrospective study
Abstract Objectives Most of the myelodysplastic syndromes (MDS) patients suffer from iron overload (IOL) due to ineffective hematopoiesis and repeated blood transfusions. IOL may affect the survival of MDS patients, but the related mechanism has not been fully clarified. We aimed to provide clinical...
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2025-07-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-025-02848-1 |
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| author | Lei Huang Yinxing Wang Xinrui Zhang Xintong Xu Ziqi Zhang XinRu Wu Chunyan Liu Rong Fu |
| author_facet | Lei Huang Yinxing Wang Xinrui Zhang Xintong Xu Ziqi Zhang XinRu Wu Chunyan Liu Rong Fu |
| author_sort | Lei Huang |
| collection | DOAJ |
| description | Abstract Objectives Most of the myelodysplastic syndromes (MDS) patients suffer from iron overload (IOL) due to ineffective hematopoiesis and repeated blood transfusions. IOL may affect the survival of MDS patients, but the related mechanism has not been fully clarified. We aimed to provide clinical evidence for the impact of IOL on the immunity and prognosis of MDS patients. Methods The clinical features and outcomes of 144 patients with MDS between March 2019 and December 2023 were analyzed. Patients were classified into the IOL group (ferritin > 1000 ng/mL) and the non-iron overload (NIOL) group (ferritin ≤ 1000 ng/mL). Results The median age of the patients was 64 (22–89) years, and IOL MDS patients had a poorer performance status. IOL MDS patients had significantly higher alanine aminotransferase and blood glucose levels. White blood cell counts and hemoglobin levels were significantly lower in IOL MDS patients. Meanwhile, the proportion of erythrocyte and megakaryocyte counts were significantly decreased in MDS patients with IOL. The incidence of 7q- chromosome abnormalities in IOL group was significantly higher. The level of Interleukin-6 was markedly elevated in patients with IOL MDS, accompanied by significant abnormalities in dendritic cells. Survival analysis indicated that IOL MDS patients had a shorter survival duration. Age ≥ 60 years, ferritin > 1000 ng/mL, complex chromosomal abnormalities, and gene mutations in TP53 and RUNX1 were independent adverse prognostic factors for MDS patients. Conclusions IOL MDS patients exhibit poorer performance status and organ function, with hematopoietic and immune function abnormalities potentially affecting their survival. |
| format | Article |
| id | doaj-art-01979a88e2c94de48ade32376eca0095 |
| institution | Kabale University |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-01979a88e2c94de48ade32376eca00952025-08-20T04:01:56ZengBMCEuropean Journal of Medical Research2047-783X2025-07-0130111110.1186/s40001-025-02848-1Clinical features and outcomes of myelodysplastic syndrome patients with iron overload: a single-center retrospective studyLei Huang0Yinxing Wang1Xinrui Zhang2Xintong Xu3Ziqi Zhang4XinRu Wu5Chunyan Liu6Rong Fu7Department of Hematology, Tianjin Medical University General HospitalDepartment of Hematology, Tianjin Medical University General HospitalDepartment of Hematology, Tianjin Medical University General HospitalDepartment of Hematology, Tianjin Medical University General HospitalDepartment of Hematology, Tianjin Medical University General HospitalDepartment of Hematology, Tianjin Medical University General HospitalDepartment of Hematology, Tianjin Medical University General HospitalDepartment of Hematology, Tianjin Medical University General HospitalAbstract Objectives Most of the myelodysplastic syndromes (MDS) patients suffer from iron overload (IOL) due to ineffective hematopoiesis and repeated blood transfusions. IOL may affect the survival of MDS patients, but the related mechanism has not been fully clarified. We aimed to provide clinical evidence for the impact of IOL on the immunity and prognosis of MDS patients. Methods The clinical features and outcomes of 144 patients with MDS between March 2019 and December 2023 were analyzed. Patients were classified into the IOL group (ferritin > 1000 ng/mL) and the non-iron overload (NIOL) group (ferritin ≤ 1000 ng/mL). Results The median age of the patients was 64 (22–89) years, and IOL MDS patients had a poorer performance status. IOL MDS patients had significantly higher alanine aminotransferase and blood glucose levels. White blood cell counts and hemoglobin levels were significantly lower in IOL MDS patients. Meanwhile, the proportion of erythrocyte and megakaryocyte counts were significantly decreased in MDS patients with IOL. The incidence of 7q- chromosome abnormalities in IOL group was significantly higher. The level of Interleukin-6 was markedly elevated in patients with IOL MDS, accompanied by significant abnormalities in dendritic cells. Survival analysis indicated that IOL MDS patients had a shorter survival duration. Age ≥ 60 years, ferritin > 1000 ng/mL, complex chromosomal abnormalities, and gene mutations in TP53 and RUNX1 were independent adverse prognostic factors for MDS patients. Conclusions IOL MDS patients exhibit poorer performance status and organ function, with hematopoietic and immune function abnormalities potentially affecting their survival.https://doi.org/10.1186/s40001-025-02848-1Myelodysplastic syndromeIron overloadHematopoiesisImmune indexPrognosis |
| spellingShingle | Lei Huang Yinxing Wang Xinrui Zhang Xintong Xu Ziqi Zhang XinRu Wu Chunyan Liu Rong Fu Clinical features and outcomes of myelodysplastic syndrome patients with iron overload: a single-center retrospective study European Journal of Medical Research Myelodysplastic syndrome Iron overload Hematopoiesis Immune index Prognosis |
| title | Clinical features and outcomes of myelodysplastic syndrome patients with iron overload: a single-center retrospective study |
| title_full | Clinical features and outcomes of myelodysplastic syndrome patients with iron overload: a single-center retrospective study |
| title_fullStr | Clinical features and outcomes of myelodysplastic syndrome patients with iron overload: a single-center retrospective study |
| title_full_unstemmed | Clinical features and outcomes of myelodysplastic syndrome patients with iron overload: a single-center retrospective study |
| title_short | Clinical features and outcomes of myelodysplastic syndrome patients with iron overload: a single-center retrospective study |
| title_sort | clinical features and outcomes of myelodysplastic syndrome patients with iron overload a single center retrospective study |
| topic | Myelodysplastic syndrome Iron overload Hematopoiesis Immune index Prognosis |
| url | https://doi.org/10.1186/s40001-025-02848-1 |
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