Clinical characteristics and usage of statins in patients with stable ischemic heart disease referred for angiography or coronary artery bypass grafting
The aim – to compare the clinical characteristics and frequency of statins usage in real clinical practice in patients referred to a specialized clinic for angiography or coronary artery bypass grafting. Materials and methods. In a retrospective slice single-center study data from a primary examina...
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TOV Chetverta Khvylia
2017-12-01
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| Series: | Кардіохірургія та інтервенційна кардіологія |
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| Online Access: | http://csic.com.ua/en/issues/current-issue/4-2017-eng/802-ultrasound-diagnosis-and-monitoring-of-fetal-tachyarrhythmias-2 |
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| author | I.V. Shklianka O.J. Zharinov К.O. Mikhaliev O.A. Epanchintseva |
| author_facet | I.V. Shklianka O.J. Zharinov К.O. Mikhaliev O.A. Epanchintseva |
| author_sort | I.V. Shklianka |
| collection | DOAJ |
| description | The aim – to compare the clinical characteristics and frequency of statins usage in real clinical practice in patients referred to a specialized clinic for angiography or coronary artery bypass grafting.
Materials and methods. In a retrospective slice single-center study data from a primary examination of 155 patients with stable ischemic heart disease, consecutively selected for coronary artery bypass grafting surgery, were analyzed. Depending on the inclusion of statins in the list of medicinal prescriptions, patients were retrospectively divided into two groups: those who had been prescribed statins while they were initially referred to a specialized cardiac surgery center for angiography or revascularization (n = 84) and those who were not prescribed statins (n = 71).
Results. The studied patients’ cohort was characterized by earlier coronary events, signs of the peripheral artery atherosclerosis and other absolute indications for treatment with statins in vast majority of cases. At the same time, groups of patients who had been and had not been prescribed statins, did not differ by vast majority of demographic, clinical and instrumental characteristics, concomitant diseases and risk factors. No statin therapy was associated with higher levels of total cholesterol and interleukin-6 compared with the group of patients taking statins (total cholesterol, respectively, 4.8 versus 4.2 mmol/l (p = 0.016) and interleukin-6, respectively, 4.4 versus. 3.1 p/ml (p = 0.022)). In general, statins were prescribed in 54,2 % of patients, among them high doses – in 17 patients (20.2 %), moderate – 46 patients (54.8 %), low – 21 patients (25 %).
Conclusions. The obtained data show the insufficient level of ambulatory statins usage in patients with ischemic heart disease referred for myocardial revascularization and significant discrepancy between clinical characteristics and real statins usage. Therefore, there is a great need to determine the optimal dosage, the timing of the appointment and suspension of treatment with statins in patients with stable ischemic heart disease being prepared for coronary artery bypass grafting surgery. |
| format | Article |
| id | doaj-art-0195dae7f04b45b3bbb57acc17295ed7 |
| institution | Kabale University |
| issn | 2305-3127 |
| language | English |
| publishDate | 2017-12-01 |
| publisher | TOV Chetverta Khvylia |
| record_format | Article |
| series | Кардіохірургія та інтервенційна кардіологія |
| spelling | doaj-art-0195dae7f04b45b3bbb57acc17295ed72025-02-02T16:18:31ZengTOV Chetverta KhvyliaКардіохірургія та інтервенційна кардіологія2305-31272017-12-014182030Clinical characteristics and usage of statins in patients with stable ischemic heart disease referred for angiography or coronary artery bypass graftingI.V. Shklianka0O.J. Zharinov1К.O. Mikhaliev2O.A. Epanchintseva3Shupyk National Medical Academy of Postgraduate Education, Kyiv, Heart Institute of Healthcare Ministry of Ukraine, KyivShupyk National Medical Academy of Postgraduate Education, KyivState Scientific Institution «Scientific and Practical Center of Preventive and Clinical Medicine» State Government Affairs, KyivShupyk National Medical Academy of Postgraduate Education, Kyiv, Heart Institute of Healthcare Ministry of Ukraine, KyivThe aim – to compare the clinical characteristics and frequency of statins usage in real clinical practice in patients referred to a specialized clinic for angiography or coronary artery bypass grafting. Materials and methods. In a retrospective slice single-center study data from a primary examination of 155 patients with stable ischemic heart disease, consecutively selected for coronary artery bypass grafting surgery, were analyzed. Depending on the inclusion of statins in the list of medicinal prescriptions, patients were retrospectively divided into two groups: those who had been prescribed statins while they were initially referred to a specialized cardiac surgery center for angiography or revascularization (n = 84) and those who were not prescribed statins (n = 71). Results. The studied patients’ cohort was characterized by earlier coronary events, signs of the peripheral artery atherosclerosis and other absolute indications for treatment with statins in vast majority of cases. At the same time, groups of patients who had been and had not been prescribed statins, did not differ by vast majority of demographic, clinical and instrumental characteristics, concomitant diseases and risk factors. No statin therapy was associated with higher levels of total cholesterol and interleukin-6 compared with the group of patients taking statins (total cholesterol, respectively, 4.8 versus 4.2 mmol/l (p = 0.016) and interleukin-6, respectively, 4.4 versus. 3.1 p/ml (p = 0.022)). In general, statins were prescribed in 54,2 % of patients, among them high doses – in 17 patients (20.2 %), moderate – 46 patients (54.8 %), low – 21 patients (25 %). Conclusions. The obtained data show the insufficient level of ambulatory statins usage in patients with ischemic heart disease referred for myocardial revascularization and significant discrepancy between clinical characteristics and real statins usage. Therefore, there is a great need to determine the optimal dosage, the timing of the appointment and suspension of treatment with statins in patients with stable ischemic heart disease being prepared for coronary artery bypass grafting surgery.http://csic.com.ua/en/issues/current-issue/4-2017-eng/802-ultrasound-diagnosis-and-monitoring-of-fetal-tachyarrhythmias-2statinsstable ischemic heart diseasecoronary artery bypass grafting |
| spellingShingle | I.V. Shklianka O.J. Zharinov К.O. Mikhaliev O.A. Epanchintseva Clinical characteristics and usage of statins in patients with stable ischemic heart disease referred for angiography or coronary artery bypass grafting Кардіохірургія та інтервенційна кардіологія statins stable ischemic heart disease coronary artery bypass grafting |
| title | Clinical characteristics and usage of statins in patients with stable ischemic heart disease referred for angiography or coronary artery bypass grafting |
| title_full | Clinical characteristics and usage of statins in patients with stable ischemic heart disease referred for angiography or coronary artery bypass grafting |
| title_fullStr | Clinical characteristics and usage of statins in patients with stable ischemic heart disease referred for angiography or coronary artery bypass grafting |
| title_full_unstemmed | Clinical characteristics and usage of statins in patients with stable ischemic heart disease referred for angiography or coronary artery bypass grafting |
| title_short | Clinical characteristics and usage of statins in patients with stable ischemic heart disease referred for angiography or coronary artery bypass grafting |
| title_sort | clinical characteristics and usage of statins in patients with stable ischemic heart disease referred for angiography or coronary artery bypass grafting |
| topic | statins stable ischemic heart disease coronary artery bypass grafting |
| url | http://csic.com.ua/en/issues/current-issue/4-2017-eng/802-ultrasound-diagnosis-and-monitoring-of-fetal-tachyarrhythmias-2 |
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