Xanthohumol ameliorates diabetic kidney disease through suppression of renal fibrosis by regulating SNHG10/miR-378b

Xanthohumol ameliorates diabetic kidney disease through suppression of renal fibrosis by regulating SNHG10/miR-378b

ContentDiabetic kidney disease (DKD), commonly termed diabetic nephropathy (DN), is characterized by oxidative stress and renal tubular epithelial cells apoptosis driven by high glucose (HG).ObjectiveTo explore the protective effects and underlying mechanism of xanthohumol in DN mice and HG-induced...

Full description

Saved in:

Bibliographic Details
Main Authors:	Jian Hao, Hui Li, Weimin Yu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-05-01
Series:	Frontiers in Pharmacology
Subjects:	xanthohumol diabetic nephropathy renal fibrosis SNHG10/miR-378b interstitial fibrosis inflammatory response
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1532517/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Prognostic significance of miR-378 in cancers: a meta-analysis
by: Lei Shi, et al.
Published: (2025-03-01)

MiR-378a-3p and miR-181b-5p as nonalcoholic steatohepatitis non-invasive diagnostic biomarkers and their correlations with liver fibrosis
by: T. I. Ahmed, et al.
Published: (2024-08-01)

Implications of the SNHG10/miR-665/RASSF5/NF-κB pathway in dihydromyricetin-mediated ischemic stroke protection
by: Qi Zeng, et al.
Published: (2024-12-01)

Low‐Magnitude High‐Frequency Vibration Attenuates Sarcopenia by Modulating Mitochondrial Quality Control via Inhibiting miR‐378
by: Yu‐Feng Long, et al.
Published: (2025-02-01)

LncTUG1 ameliorates renal tubular fibrosis in experimental diabetic nephropathy through the miR-145-5p/dual-specificity phosphatase 6 axis
by: Taoxia Wang, et al.
Published: (2023-12-01)

Metformin Inhibits the Progression of Pancreatic Cancer Through Regulating miR‐378a‐3p/VEGFA/RGC‐32 Axis
by: Jinli He, et al.
Published: (2024-12-01)

RETRACTED: LncRNA SNHG14 contributes to the progression of NSCLC through miR‐206/G6PD pathway
by: Lin Zhao, et al.
Published: (2020-05-01)

Dihydromyricetin inhibits injury caused by ischemic stroke through the lncRNA SNHG17/miR-452-3p/CXCR4 axis
by: Jiacheng Xie, et al.
Published: (2025-01-01)

Silencing long non-coding RNA SNHG6 restrains proliferation, migration and invasion of Wilms’ tumour cell lines by regulating miR-15a
by: Limin Su, et al.
Published: (2019-12-01)

The expression and significance of miR-378a in oral squamous cell carcinoma
by: CHEN Yan, et al.
Published: (2023-04-01)

miR-210 overexpression increases pressure overload-induced cardiac fibrosis
by: G. Zaccagnini, et al.
Published: (2025-06-01)

Yishen-Huoxue formula alleviates renal interstitial fibrosis by attenuating hypoxia-induced renal cell injury and promoting angiogenesis via miR-210/HIF-1α pathway
by: Mouying Du, et al.
Published: (2025-05-01)

Long non‐coding RNA SNHG6 promotes the growth and invasion of non‐small cell lung cancer by downregulating miR‐101‐3p
by: Ke Li, et al.
Published: (2020-05-01)

Effect of lncRNA SNHG22 targeting miR-27b-3p on regulation of glioma progression and prognosis
by: Jin Feng, et al.
Published: (2024-11-01)

Krüppel-like factor 4 modulates the miR-101/COL10A1 axis to inhibit renal fibrosis after AKI by regulating epithelial–mesenchymal transition
by: Jingying Zhao, et al.
Published: (2024-12-01)

Snhg12 targets miR-199a-5p to regulate osteogenic differentiation of TDSCs via the Fzd4/Wnt/β-catenin pathway
by: Xinyue Li, et al.
Published: (2025-12-01)

Diagnostic value of LncRNA SNHG16 for osteoporotic fractures and its potential regulation of fracture healing
by: Yuanming Luo, et al.
Published: (2025-04-01)

LncRNA SNHG16 promotes LPS-induced human bronchial epithelial cell pyroptosis through miR-339-5p/NLRP1 axis mediation
by: Hui Liu, et al.
Published: (2024-12-01)

Long non-coding RNA SNHG16 promotes tumor progression and cisplatin resistance in esophageal squamous cell carcinoma via miR-497-5p/HK2 axis
by: Xiaofeng Zhu, et al.
Published: (2025-07-01)

The mechanism of plasma exosome miR-15a-5p targeting the CF-modified protein IGF1R to regulate alveolar epithelial autophagy and influence pulmonary interstitial fibrosis
by: Yina Li, et al.
Published: (2025-12-01)

SERUM LncRNA SNHG16: A Biomarker for Diagnosing Childhood Obesity and Predicting Its Progression to Metabolic Syndrome
by: Hu J, et al.
Published: (2025-07-01)

MiR-383-5p promotes schistosomiasis-induced liver fibrosis by targeting peroxiredoxin-3
by: Yi-Xin Li, et al.
Published: (2025-06-01)

Inhalable Hsa‐miR‐30a‐3p Liposomes Attenuate Pulmonary Fibrosis
by: Shuo Liu, et al.
Published: (2025-05-01)

Clinical significance of miR-6515-5p in predicting diagnosis and prognosis for acute respiratory distress syndrome suffering from pulmonary fibrosis
by: Xueqin Huang, et al.
Published: (2025-04-01)

Hepatic stellate cell-specific miR-214 expression alleviates liver fibrosis without boosting steatosis and inflammation
by: Fangqing Zhao, et al.
Published: (2025-07-01)

Expression and significance of miR-200c in mesothelial cells of the peritoneal dialysate effluent fluid of peritoneal dialysis patients
by: ZHANG Lin, et al.
Published: (2018-01-01)

Inhibition of renal interstitial fibrosis by mulberry leaf alkaloids in rats with diabetic nephropathy
by: Feng Wu, et al.
Published: (2022-08-01)

Functions and mechanisms of UC-MSC-derived exosomal miR-486-5p in pulmonary fibrosis
by: Xue-feng Shi, et al.
Published: (2025-07-01)

Schisandrin B suppresses liver fibrosis in rats by targeting miR-101-5p through the TGF-β signaling pathway
by: Wang Cuiqiong, et al.
Published: (2020-01-01)

Antioxidant Potential of Xanthohumol in Disease Prevention: Evidence from Human and Animal Studies
by: Jakub Piekara, et al.
Published: (2024-12-01)

A Systematic Review of the Expression Pattern of Long Non-Coding RNAs SNHG5, SNHG17, and SNHG26 in Human Solid Tumors
by: Elham Aminifar, et al.
Published: (2024-12-01)

LncRNA GAS5 reduces blood glucose levels and alleviates renal fibrosis in diabetic nephropathy by regulating the miR-542-3p/ERBB4 axis
by: Qinghua Yin, et al.
Published: (2025-01-01)

Expression level, correlation, and diagnostic value of serum miR-99a in pulmonary fibrosis in patients with acute respiratory distress syndrome
by: Lanlan Chen, et al.
Published: (2025-06-01)

MiR-221, miR-320a, miR133a, and miR-133b as potential biomarkers in leiomyosarcoma
by: Mst Nasrin Akhtar, et al.
Published: (2025-06-01)

CircPWWP2A promotes renal interstitial fibrosis through modulating miR-182/ROCK1 axis
by: Qian Huang, et al.
Published: (2024-12-01)

miR-21 in cardiovascular disease: new insights and emerging therapeutic potential
by: Elina Mollajan, et al.
Published: (2025-05-01)

Pathogenetic mechanisms of nephropathy formation in type 1 diabetes mellitus
by: L. V. Kutsenko, et al.
Published: (2021-06-01)

Entacapone’s therapeutic potential in renal fibrosis by targeting miR-34a/TGFβ1/Smad2 signaling: an experimental rat model study
by: Yosra M. Magdy, et al.
Published: (2025-06-01)

Human umbilical cord mesenchymal stem cells ameliorate liver fibrosis by inhibiting hepatocyte ferroptosis and macrophage polarization via the miR-455-3p/PLAU axis
by: Yong Zhang, et al.
Published: (2025-07-01)

Biochemical analysis of miR-217 and miR-532 in patients with fibromyalgia
by: Shymaa E. Ayoub, et al.
Published: (2025-02-01)