Relevance Epistasis Network of Gastritis for Intra-chromosomes in the Korea Associated Resource (KARE) Cohort Study
Gastritis is a common but a serious disease with a potential risk of developing carcinoma. Helicobacter pylori infection is reported as the most common cause of gastritis, but other genetic and genomic factors exist, especially single-nucleotide polymorphisms (SNPs). Association studies between SNPs...
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BioMed Central
2014-12-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gni-12-216.pdf |
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| author | Hyun-hwan Jeong Kyung-Ah Sohn |
| author_facet | Hyun-hwan Jeong Kyung-Ah Sohn |
| author_sort | Hyun-hwan Jeong |
| collection | DOAJ |
| description | Gastritis is a common but a serious disease with a potential risk of developing carcinoma. Helicobacter pylori infection is reported as the most common cause of gastritis, but other genetic and genomic factors exist, especially single-nucleotide polymorphisms (SNPs). Association studies between SNPs and gastritis disease are important, but results on epistatic interactions from multiple SNPs are rarely found in previous genome-wide association (GWA) studies. In this study, we performed computational GWA case-control studies for gastritis in Korea Associated Resource (KARE) data. By transforming the resulting SNP epistasis network into a gene-gene epistasis network, we also identified potential gene-gene interaction factors that affect the susceptibility to gastritis. |
| format | Article |
| id | doaj-art-0180f9265b2046cbab02916d6d53243e |
| institution | Kabale University |
| issn | 1598-866X 2234-0742 |
| language | English |
| publishDate | 2014-12-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-0180f9265b2046cbab02916d6d53243e2025-02-02T00:12:16ZengBioMed CentralGenomics & Informatics1598-866X2234-07422014-12-0112421622410.5808/GI.2014.12.4.216108Relevance Epistasis Network of Gastritis for Intra-chromosomes in the Korea Associated Resource (KARE) Cohort StudyHyun-hwan Jeong0Kyung-Ah Sohn1Department of Information and Computer Engineering, Ajou University, Suwon 443-749, Korea.Department of Information and Computer Engineering, Ajou University, Suwon 443-749, Korea.Gastritis is a common but a serious disease with a potential risk of developing carcinoma. Helicobacter pylori infection is reported as the most common cause of gastritis, but other genetic and genomic factors exist, especially single-nucleotide polymorphisms (SNPs). Association studies between SNPs and gastritis disease are important, but results on epistatic interactions from multiple SNPs are rarely found in previous genome-wide association (GWA) studies. In this study, we performed computational GWA case-control studies for gastritis in Korea Associated Resource (KARE) data. By transforming the resulting SNP epistasis network into a gene-gene epistasis network, we also identified potential gene-gene interaction factors that affect the susceptibility to gastritis.http://genominfo.org/upload/pdf/gni-12-216.pdfgastritisgenome-wide association studyKAREmutual informationrelevance networksingle-nucleotide polymorphism |
| spellingShingle | Hyun-hwan Jeong Kyung-Ah Sohn Relevance Epistasis Network of Gastritis for Intra-chromosomes in the Korea Associated Resource (KARE) Cohort Study Genomics & Informatics gastritis genome-wide association study KARE mutual information relevance network single-nucleotide polymorphism |
| title | Relevance Epistasis Network of Gastritis for Intra-chromosomes in the Korea Associated Resource (KARE) Cohort Study |
| title_full | Relevance Epistasis Network of Gastritis for Intra-chromosomes in the Korea Associated Resource (KARE) Cohort Study |
| title_fullStr | Relevance Epistasis Network of Gastritis for Intra-chromosomes in the Korea Associated Resource (KARE) Cohort Study |
| title_full_unstemmed | Relevance Epistasis Network of Gastritis for Intra-chromosomes in the Korea Associated Resource (KARE) Cohort Study |
| title_short | Relevance Epistasis Network of Gastritis for Intra-chromosomes in the Korea Associated Resource (KARE) Cohort Study |
| title_sort | relevance epistasis network of gastritis for intra chromosomes in the korea associated resource kare cohort study |
| topic | gastritis genome-wide association study KARE mutual information relevance network single-nucleotide polymorphism |
| url | http://genominfo.org/upload/pdf/gni-12-216.pdf |
| work_keys_str_mv | AT hyunhwanjeong relevanceepistasisnetworkofgastritisforintrachromosomesinthekoreaassociatedresourcekarecohortstudy AT kyungahsohn relevanceepistasisnetworkofgastritisforintrachromosomesinthekoreaassociatedresourcekarecohortstudy |