Therapeutic Implications of Targeting Energy Metabolism in Breast Cancer
PPARs are ligand activated transcription factors. PPARγ agonists have been reported as a new and potentially efficacious treatment of inflammation, diabetes, obesity, cancer, AD, and schizophrenia. Since cancer cells show dysregulation of glycolysis they are potentially manageable through changes in...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2013/109285 |
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| author | Meena K. Sakharkar Babita Shashni Karun Sharma Sarinder K. Dhillon Prabhakar R. Ranjekar Kishore R. Sakharkar |
| author_facet | Meena K. Sakharkar Babita Shashni Karun Sharma Sarinder K. Dhillon Prabhakar R. Ranjekar Kishore R. Sakharkar |
| author_sort | Meena K. Sakharkar |
| collection | DOAJ |
| description | PPARs are ligand activated transcription factors. PPARγ agonists have been reported as a new and potentially efficacious treatment of inflammation, diabetes, obesity, cancer, AD, and schizophrenia. Since cancer cells show dysregulation of glycolysis they are potentially manageable through changes in metabolic environment. Interestingly, several of the genes involved in maintaining the metabolic environment and the central energy generation pathway are regulated or predicted to be regulated by PPARγ. The use of synthetic PPARγ ligands as drugs and their recent withdrawal/restricted usage highlight the lack of understanding of the molecular basis of these drugs, their off-target effects, and their network. These data further underscores the complexity of nuclear receptor signalling mechanisms. This paper will discuss the function and role of PPARγ in energy metabolism and cancer biology in general and its emergence as a promising therapeutic target in breast cancer. |
| format | Article |
| id | doaj-art-017f8394eb644f65b92965251b7c5f72 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-017f8394eb644f65b92965251b7c5f722025-02-03T06:12:45ZengWileyPPAR Research1687-47571687-47652013-01-01201310.1155/2013/109285109285Therapeutic Implications of Targeting Energy Metabolism in Breast CancerMeena K. Sakharkar0Babita Shashni1Karun Sharma2Sarinder K. Dhillon3Prabhakar R. Ranjekar4Kishore R. Sakharkar5Graduate School of Life and Environmental Sciences, University of Tsukuba, Tennoudai 1-1-1, Tsukuba 305-8572, JapanGraduate School of Life and Environmental Sciences, University of Tsukuba, Tennoudai 1-1-1, Tsukuba 305-8572, JapanGraduate School of Life and Environmental Sciences, University of Tsukuba, Tennoudai 1-1-1, Tsukuba 305-8572, JapanInstitute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, MalaysiaIRSHA, Bharati Vidyapeeth University, Pune 411043, IndiaOmicsvista, 120417, SingaporePPARs are ligand activated transcription factors. PPARγ agonists have been reported as a new and potentially efficacious treatment of inflammation, diabetes, obesity, cancer, AD, and schizophrenia. Since cancer cells show dysregulation of glycolysis they are potentially manageable through changes in metabolic environment. Interestingly, several of the genes involved in maintaining the metabolic environment and the central energy generation pathway are regulated or predicted to be regulated by PPARγ. The use of synthetic PPARγ ligands as drugs and their recent withdrawal/restricted usage highlight the lack of understanding of the molecular basis of these drugs, their off-target effects, and their network. These data further underscores the complexity of nuclear receptor signalling mechanisms. This paper will discuss the function and role of PPARγ in energy metabolism and cancer biology in general and its emergence as a promising therapeutic target in breast cancer.http://dx.doi.org/10.1155/2013/109285 |
| spellingShingle | Meena K. Sakharkar Babita Shashni Karun Sharma Sarinder K. Dhillon Prabhakar R. Ranjekar Kishore R. Sakharkar Therapeutic Implications of Targeting Energy Metabolism in Breast Cancer PPAR Research |
| title | Therapeutic Implications of Targeting Energy Metabolism in Breast Cancer |
| title_full | Therapeutic Implications of Targeting Energy Metabolism in Breast Cancer |
| title_fullStr | Therapeutic Implications of Targeting Energy Metabolism in Breast Cancer |
| title_full_unstemmed | Therapeutic Implications of Targeting Energy Metabolism in Breast Cancer |
| title_short | Therapeutic Implications of Targeting Energy Metabolism in Breast Cancer |
| title_sort | therapeutic implications of targeting energy metabolism in breast cancer |
| url | http://dx.doi.org/10.1155/2013/109285 |
| work_keys_str_mv | AT meenaksakharkar therapeuticimplicationsoftargetingenergymetabolisminbreastcancer AT babitashashni therapeuticimplicationsoftargetingenergymetabolisminbreastcancer AT karunsharma therapeuticimplicationsoftargetingenergymetabolisminbreastcancer AT sarinderkdhillon therapeuticimplicationsoftargetingenergymetabolisminbreastcancer AT prabhakarrranjekar therapeuticimplicationsoftargetingenergymetabolisminbreastcancer AT kishorersakharkar therapeuticimplicationsoftargetingenergymetabolisminbreastcancer |