Effects of low-flux and high-flux hemodialysis on the survival of elderly maintenance hemodialysis patients
Background Elderly hemodialysis (HD) patients have a high risk of death. The effect of different types of HD membranes on survival is still controversial. The purpose of this study was to determine the relationship between the use of low-flux or high-flux membranes and all-cause and cardiovascular m...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2338217 |
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| author | Wanqing Huang Jiuxu Bai Yanping Zhang Dongxia Qiu Lin Wei Chen Zhao Zhuo Ren Qian Wang Kaiming Ren Ning Cao |
| author_facet | Wanqing Huang Jiuxu Bai Yanping Zhang Dongxia Qiu Lin Wei Chen Zhao Zhuo Ren Qian Wang Kaiming Ren Ning Cao |
| author_sort | Wanqing Huang |
| collection | DOAJ |
| description | Background Elderly hemodialysis (HD) patients have a high risk of death. The effect of different types of HD membranes on survival is still controversial. The purpose of this study was to determine the relationship between the use of low-flux or high-flux membranes and all-cause and cardiovascular mortality in elderly hemodialysis patients.Methods This was a retrospective clinical study involving maintenance hemodialysis patients which were categorized into low-flux and high-flux groups according to the dialyzer they were using. Propensity score matching was used to balance the baseline data of the two groups. Survival rates were compared between the two groups, and the risk factors for death were analyzed by multivariate Cox regression.Results Kaplan–Meier survival analysis revealed no significant difference in all-cause mortality between the low-flux group and the high-flux group (log-rank test, p = 0.559). Cardiovascular mortality was significantly greater in the low-flux group than in the high-flux group (log-rank test, p = 0.049). After adjustment through three different multivariate models, we detected no significant difference in all-cause mortality. Patients in the high-flux group had a lower risk of cardiovascular death than did those in the low-flux group (HR = 0.79, 95% CI, 0.54–1.16, p = 0.222; HR = 0.58, 95% CI, 0.37–0.91, p = 0.019).Conclusions High-flux hemodialysis was associated with a lower relative risk of cardiovascular mortality in elderly MHD patients. High-flux hemodialysis did not improve all-cause mortality rate. Differences in urea distribution volume, blood flow, and systemic differences in solute clearance by dialyzers were not further analyzed, which are the limitations of this study. |
| format | Article |
| id | doaj-art-017b27ddf872400a8d89cd19c3e541fb |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-017b27ddf872400a8d89cd19c3e541fb2025-01-23T04:17:48ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2024.2338217Effects of low-flux and high-flux hemodialysis on the survival of elderly maintenance hemodialysis patientsWanqing Huang0Jiuxu Bai1Yanping Zhang2Dongxia Qiu3Lin Wei4Chen Zhao5Zhuo Ren6Qian Wang7Kaiming Ren8Ning Cao9Postgraduate., Training Base of Jinzhou Medical University (General Hospital of Northern Theater Command), Jinzhou, ChinaDepartment of Blood Purification, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Blood Purification, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Blood Purification, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Blood Purification, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Blood Purification, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Blood Purification, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Blood Purification, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Blood Purification, General Hospital of Northern Theater Command, Shenyang, ChinaDepartment of Blood Purification, General Hospital of Northern Theater Command, Shenyang, ChinaBackground Elderly hemodialysis (HD) patients have a high risk of death. The effect of different types of HD membranes on survival is still controversial. The purpose of this study was to determine the relationship between the use of low-flux or high-flux membranes and all-cause and cardiovascular mortality in elderly hemodialysis patients.Methods This was a retrospective clinical study involving maintenance hemodialysis patients which were categorized into low-flux and high-flux groups according to the dialyzer they were using. Propensity score matching was used to balance the baseline data of the two groups. Survival rates were compared between the two groups, and the risk factors for death were analyzed by multivariate Cox regression.Results Kaplan–Meier survival analysis revealed no significant difference in all-cause mortality between the low-flux group and the high-flux group (log-rank test, p = 0.559). Cardiovascular mortality was significantly greater in the low-flux group than in the high-flux group (log-rank test, p = 0.049). After adjustment through three different multivariate models, we detected no significant difference in all-cause mortality. Patients in the high-flux group had a lower risk of cardiovascular death than did those in the low-flux group (HR = 0.79, 95% CI, 0.54–1.16, p = 0.222; HR = 0.58, 95% CI, 0.37–0.91, p = 0.019).Conclusions High-flux hemodialysis was associated with a lower relative risk of cardiovascular mortality in elderly MHD patients. High-flux hemodialysis did not improve all-cause mortality rate. Differences in urea distribution volume, blood flow, and systemic differences in solute clearance by dialyzers were not further analyzed, which are the limitations of this study.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2338217High-fluxlow-fluxhemodialysiselderlysurvival |
| spellingShingle | Wanqing Huang Jiuxu Bai Yanping Zhang Dongxia Qiu Lin Wei Chen Zhao Zhuo Ren Qian Wang Kaiming Ren Ning Cao Effects of low-flux and high-flux hemodialysis on the survival of elderly maintenance hemodialysis patients Renal Failure High-flux low-flux hemodialysis elderly survival |
| title | Effects of low-flux and high-flux hemodialysis on the survival of elderly maintenance hemodialysis patients |
| title_full | Effects of low-flux and high-flux hemodialysis on the survival of elderly maintenance hemodialysis patients |
| title_fullStr | Effects of low-flux and high-flux hemodialysis on the survival of elderly maintenance hemodialysis patients |
| title_full_unstemmed | Effects of low-flux and high-flux hemodialysis on the survival of elderly maintenance hemodialysis patients |
| title_short | Effects of low-flux and high-flux hemodialysis on the survival of elderly maintenance hemodialysis patients |
| title_sort | effects of low flux and high flux hemodialysis on the survival of elderly maintenance hemodialysis patients |
| topic | High-flux low-flux hemodialysis elderly survival |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2338217 |
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