The Interaction Effects of Suicidal Ideation and Childhood Abuse on Brain Structure and Function in Major Depressive Disorder Patients
Suicidal ideation (SI) is a direct risk factor for suicide in patients with depression. Regarding the emergence of SI, previous studies have discovered many risk factors, including childhood abuse as the major public problem. Previous imaging studies have demonstrated that SI or childhood abuse has...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2021/7088856 |
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| author | Wei Wang Lijun Kang Nan Zhang Xin Guo Peilin Wang Xiaofen Zong Lihua Yao Hanping Bai Jing Cheng Ning Tu Hongyan Feng Gaohua Wang Lihong Bu Fei Wang Zhongchun Liu |
| author_facet | Wei Wang Lijun Kang Nan Zhang Xin Guo Peilin Wang Xiaofen Zong Lihua Yao Hanping Bai Jing Cheng Ning Tu Hongyan Feng Gaohua Wang Lihong Bu Fei Wang Zhongchun Liu |
| author_sort | Wei Wang |
| collection | DOAJ |
| description | Suicidal ideation (SI) is a direct risk factor for suicide in patients with depression. Regarding the emergence of SI, previous studies have discovered many risk factors, including childhood abuse as the major public problem. Previous imaging studies have demonstrated that SI or childhood abuse has effects on brain structure and function, respectively, but the interaction effects between them have not been fully studied. To explore the interaction effect between SI and childhood abuse, 215 patients with major depressive disorder completed the Childhood Trauma Questionnaire to evaluate childhood abuse and Beck’s Scale for Suicidal Ideation to evaluate SI. Then, they completed magnetic resonance imaging (MRI) within one week after completing questionnaires. Respectively, we preprocessed the structural and functional images and analyzed gray matter volumes (GMV) and mean fractional amplitude of low-frequency fluctuation (mfALFF) values. Results showed that the changes of GMV in the cuneus, precuneus, paracentric lobule, inferior frontal gyrus, and caudate nucleus and local activity in cuneal and middle temporal gyrus are in relation with SI and childhood abuse. And in left caudate, SI and childhood abuse interact with each other on the influence of GMV. That is, the influence of SI in GMV was related to childhood abuse, and the influence of childhood abuse in GMV was also related to SI. Therefore, the combination of SI and childhood abuse based on imaging should help us better understand the suicide ideation developing mechanism and propose more effective targeted prevention strategies for suicide prevention. |
| format | Article |
| id | doaj-art-017550beefc0406e8daca716c9bc374e |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-017550beefc0406e8daca716c9bc374e2025-02-03T01:08:48ZengWileyNeural Plasticity2090-59041687-54432021-01-01202110.1155/2021/70888567088856The Interaction Effects of Suicidal Ideation and Childhood Abuse on Brain Structure and Function in Major Depressive Disorder PatientsWei Wang0Lijun Kang1Nan Zhang2Xin Guo3Peilin Wang4Xiaofen Zong5Lihua Yao6Hanping Bai7Jing Cheng8Ning Tu9Hongyan Feng10Gaohua Wang11Lihong Bu12Fei Wang13Zhongchun Liu14Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaPET/CT/MRI and Molecular Imaging Center, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaPET/CT/MRI and Molecular Imaging Center, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaPET/CT/MRI and Molecular Imaging Center, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaEarly Intervention Unit, Department of Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaSuicidal ideation (SI) is a direct risk factor for suicide in patients with depression. Regarding the emergence of SI, previous studies have discovered many risk factors, including childhood abuse as the major public problem. Previous imaging studies have demonstrated that SI or childhood abuse has effects on brain structure and function, respectively, but the interaction effects between them have not been fully studied. To explore the interaction effect between SI and childhood abuse, 215 patients with major depressive disorder completed the Childhood Trauma Questionnaire to evaluate childhood abuse and Beck’s Scale for Suicidal Ideation to evaluate SI. Then, they completed magnetic resonance imaging (MRI) within one week after completing questionnaires. Respectively, we preprocessed the structural and functional images and analyzed gray matter volumes (GMV) and mean fractional amplitude of low-frequency fluctuation (mfALFF) values. Results showed that the changes of GMV in the cuneus, precuneus, paracentric lobule, inferior frontal gyrus, and caudate nucleus and local activity in cuneal and middle temporal gyrus are in relation with SI and childhood abuse. And in left caudate, SI and childhood abuse interact with each other on the influence of GMV. That is, the influence of SI in GMV was related to childhood abuse, and the influence of childhood abuse in GMV was also related to SI. Therefore, the combination of SI and childhood abuse based on imaging should help us better understand the suicide ideation developing mechanism and propose more effective targeted prevention strategies for suicide prevention.http://dx.doi.org/10.1155/2021/7088856 |
| spellingShingle | Wei Wang Lijun Kang Nan Zhang Xin Guo Peilin Wang Xiaofen Zong Lihua Yao Hanping Bai Jing Cheng Ning Tu Hongyan Feng Gaohua Wang Lihong Bu Fei Wang Zhongchun Liu The Interaction Effects of Suicidal Ideation and Childhood Abuse on Brain Structure and Function in Major Depressive Disorder Patients Neural Plasticity |
| title | The Interaction Effects of Suicidal Ideation and Childhood Abuse on Brain Structure and Function in Major Depressive Disorder Patients |
| title_full | The Interaction Effects of Suicidal Ideation and Childhood Abuse on Brain Structure and Function in Major Depressive Disorder Patients |
| title_fullStr | The Interaction Effects of Suicidal Ideation and Childhood Abuse on Brain Structure and Function in Major Depressive Disorder Patients |
| title_full_unstemmed | The Interaction Effects of Suicidal Ideation and Childhood Abuse on Brain Structure and Function in Major Depressive Disorder Patients |
| title_short | The Interaction Effects of Suicidal Ideation and Childhood Abuse on Brain Structure and Function in Major Depressive Disorder Patients |
| title_sort | interaction effects of suicidal ideation and childhood abuse on brain structure and function in major depressive disorder patients |
| url | http://dx.doi.org/10.1155/2021/7088856 |
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