The Survivin −31 Snp in Human Colorectal Cancer Correlates with Survivin Splice Variant Expression and Improved Overall Survival

Background: Survivin is involved in the regulation of cell division and survival, two key processes in cancer. The majority of studies on survivin in colorectal cancer (CRC) have focused on protein expression and less is known about the expression of survivin splicing variants or survivin gene polym...

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Main Authors: Anna G. Antonacopoulou, Konstantina Floratou, Vasiliki Bravou, Anastasia Kottorou, Fotinos-Ioannis Dimitrakopoulos, Stella Marousi, Michalis Stavropoulos, Agelos K. Koutras, Chrisoula D. Scopa, Haralabos P. Kalofonos
Format: Article
Language:English
Published: Wiley 2010-01-01
Series:Analytical Cellular Pathology
Online Access:http://dx.doi.org/10.3233/ACP-CLO-2010-0537
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author Anna G. Antonacopoulou
Konstantina Floratou
Vasiliki Bravou
Anastasia Kottorou
Fotinos-Ioannis Dimitrakopoulos
Stella Marousi
Michalis Stavropoulos
Agelos K. Koutras
Chrisoula D. Scopa
Haralabos P. Kalofonos
author_facet Anna G. Antonacopoulou
Konstantina Floratou
Vasiliki Bravou
Anastasia Kottorou
Fotinos-Ioannis Dimitrakopoulos
Stella Marousi
Michalis Stavropoulos
Agelos K. Koutras
Chrisoula D. Scopa
Haralabos P. Kalofonos
author_sort Anna G. Antonacopoulou
collection DOAJ
description Background: Survivin is involved in the regulation of cell division and survival, two key processes in cancer. The majority of studies on survivin in colorectal cancer (CRC) have focused on protein expression and less is known about the expression of survivin splicing variants or survivin gene polymorphisms in CRC. In the present study, the mRNA levels of the five known isoforms of survivin as well as survivin protein were assessed in matched normal and neoplastic colorectal tissue. Moreover, the 9386C/T and −31G/C polymorphisms were investigated.
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institution Kabale University
issn 2210-7177
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language English
publishDate 2010-01-01
publisher Wiley
record_format Article
series Analytical Cellular Pathology
spelling doaj-art-016a4c6664bd4f1b95e555abacca12b22025-02-03T05:52:40ZengWileyAnalytical Cellular Pathology2210-71772210-71852010-01-01335-617718910.3233/ACP-CLO-2010-0537The Survivin −31 Snp in Human Colorectal Cancer Correlates with Survivin Splice Variant Expression and Improved Overall SurvivalAnna G. Antonacopoulou0Konstantina Floratou1Vasiliki Bravou2Anastasia Kottorou3Fotinos-Ioannis Dimitrakopoulos4Stella Marousi5Michalis Stavropoulos6Agelos K. Koutras7Chrisoula D. Scopa8Haralabos P. Kalofonos9Molecular Oncology Laboratory, Medical School, University of Patras, Rion, GreeceMolecular Oncology Laboratory, Medical School, University of Patras, Rion, GreeceMolecular Oncology Laboratory, Medical School, University of Patras, Rion, GreeceMolecular Oncology Laboratory, Medical School, University of Patras, Rion, GreeceMolecular Oncology Laboratory, Medical School, University of Patras, Rion, GreeceMolecular Oncology Laboratory, Medical School, University of Patras, Rion, GreeceDepartment of Surgery, Medical School, University of Patras, Rion, GreeceMolecular Oncology Laboratory, Medical School, University of Patras, Rion, GreeceDepartment of Pathology, Medical School, University of Patras, Rion, GreeceMolecular Oncology Laboratory, Medical School, University of Patras, Rion, GreeceBackground: Survivin is involved in the regulation of cell division and survival, two key processes in cancer. The majority of studies on survivin in colorectal cancer (CRC) have focused on protein expression and less is known about the expression of survivin splicing variants or survivin gene polymorphisms in CRC. In the present study, the mRNA levels of the five known isoforms of survivin as well as survivin protein were assessed in matched normal and neoplastic colorectal tissue. Moreover, the 9386C/T and −31G/C polymorphisms were investigated.http://dx.doi.org/10.3233/ACP-CLO-2010-0537
spellingShingle Anna G. Antonacopoulou
Konstantina Floratou
Vasiliki Bravou
Anastasia Kottorou
Fotinos-Ioannis Dimitrakopoulos
Stella Marousi
Michalis Stavropoulos
Agelos K. Koutras
Chrisoula D. Scopa
Haralabos P. Kalofonos
The Survivin −31 Snp in Human Colorectal Cancer Correlates with Survivin Splice Variant Expression and Improved Overall Survival
Analytical Cellular Pathology
title The Survivin −31 Snp in Human Colorectal Cancer Correlates with Survivin Splice Variant Expression and Improved Overall Survival
title_full The Survivin −31 Snp in Human Colorectal Cancer Correlates with Survivin Splice Variant Expression and Improved Overall Survival
title_fullStr The Survivin −31 Snp in Human Colorectal Cancer Correlates with Survivin Splice Variant Expression and Improved Overall Survival
title_full_unstemmed The Survivin −31 Snp in Human Colorectal Cancer Correlates with Survivin Splice Variant Expression and Improved Overall Survival
title_short The Survivin −31 Snp in Human Colorectal Cancer Correlates with Survivin Splice Variant Expression and Improved Overall Survival
title_sort survivin 31 snp in human colorectal cancer correlates with survivin splice variant expression and improved overall survival
url http://dx.doi.org/10.3233/ACP-CLO-2010-0537
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