Neurological damages in COVID‐19 patients: Mechanisms and preventive interventions
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), a novel coronavirus, causes coronavirus disease 2019 (COVID‐19) which led to neurological damage and increased mortality worldwide in its second and third waves. It is associated with systemic inflammation, myocardial infarction,...
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| Format: | Article |
| Language: | English |
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Wiley
2023-04-01
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| Series: | MedComm |
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| Online Access: | https://doi.org/10.1002/mco2.247 |
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| author | Sibani Sarkar Subhajit Karmakar Malini Basu Pratyasha Ghosh Mrinal K Ghosh |
| author_facet | Sibani Sarkar Subhajit Karmakar Malini Basu Pratyasha Ghosh Mrinal K Ghosh |
| author_sort | Sibani Sarkar |
| collection | DOAJ |
| description | Abstract Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), a novel coronavirus, causes coronavirus disease 2019 (COVID‐19) which led to neurological damage and increased mortality worldwide in its second and third waves. It is associated with systemic inflammation, myocardial infarction, neurological illness including ischemic strokes (e.g., cardiac and cerebral ischemia), and even death through multi‐organ failure. At the early stage, the virus infects the lung epithelial cells and is slowly transmitted to the other organs including the gastrointestinal tract, blood vessels, kidneys, heart, and brain. The neurological effect of the virus is mainly due to hypoxia‐driven reactive oxygen species (ROS) and generated cytokine storm. Internalization of SARS‐CoV‐2 triggers ROS production and modulation of the immunological cascade which ultimately initiates the hypercoagulable state and vascular thrombosis. Suppression of immunological machinery and inhibition of ROS play an important role in neurological disturbances. So, COVID‐19 associated damage to the central nervous system, patients need special care to prevent multi‐organ failure at later stages of disease progression. Here in this review, we are selectively discussing these issues and possible antioxidant‐based prevention therapies for COVID‐19‐associated neurological damage that leads to multi‐organ failure. |
| format | Article |
| id | doaj-art-0162ed19406a46fc887bba1aac9daf19 |
| institution | Kabale University |
| issn | 2688-2663 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm |
| spelling | doaj-art-0162ed19406a46fc887bba1aac9daf192025-01-24T05:36:29ZengWileyMedComm2688-26632023-04-0142n/an/a10.1002/mco2.247Neurological damages in COVID‐19 patients: Mechanisms and preventive interventionsSibani Sarkar0Subhajit Karmakar1Malini Basu2Pratyasha Ghosh3Mrinal K Ghosh4Division of Cancer Biology and Inflammatory Disorder Signal Transduction in Cancer and Stem Cells Laboratory Council of Scientific and Industrial Research‐Indian Institute of Chemical Biology (CSIR‐IICB) Kolkata IndiaDivision of Cancer Biology and Inflammatory Disorder Signal Transduction in Cancer and Stem Cells Laboratory Council of Scientific and Industrial Research‐Indian Institute of Chemical Biology (CSIR‐IICB) Kolkata IndiaDepartment of Microbiology Dhruba Chand Halder College, University of Calcutta Dakshin Barasat WB IndiaDepartment of Economics Bethune College University of Calcutta Kolkata IndiaDivision of Cancer Biology and Inflammatory Disorder Signal Transduction in Cancer and Stem Cells Laboratory Council of Scientific and Industrial Research‐Indian Institute of Chemical Biology (CSIR‐IICB) Kolkata IndiaAbstract Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), a novel coronavirus, causes coronavirus disease 2019 (COVID‐19) which led to neurological damage and increased mortality worldwide in its second and third waves. It is associated with systemic inflammation, myocardial infarction, neurological illness including ischemic strokes (e.g., cardiac and cerebral ischemia), and even death through multi‐organ failure. At the early stage, the virus infects the lung epithelial cells and is slowly transmitted to the other organs including the gastrointestinal tract, blood vessels, kidneys, heart, and brain. The neurological effect of the virus is mainly due to hypoxia‐driven reactive oxygen species (ROS) and generated cytokine storm. Internalization of SARS‐CoV‐2 triggers ROS production and modulation of the immunological cascade which ultimately initiates the hypercoagulable state and vascular thrombosis. Suppression of immunological machinery and inhibition of ROS play an important role in neurological disturbances. So, COVID‐19 associated damage to the central nervous system, patients need special care to prevent multi‐organ failure at later stages of disease progression. Here in this review, we are selectively discussing these issues and possible antioxidant‐based prevention therapies for COVID‐19‐associated neurological damage that leads to multi‐organ failure.https://doi.org/10.1002/mco2.247antioxidantCOVID‐19ischemianeurological damageprevention therapyROS |
| spellingShingle | Sibani Sarkar Subhajit Karmakar Malini Basu Pratyasha Ghosh Mrinal K Ghosh Neurological damages in COVID‐19 patients: Mechanisms and preventive interventions MedComm antioxidant COVID‐19 ischemia neurological damage prevention therapy ROS |
| title | Neurological damages in COVID‐19 patients: Mechanisms and preventive interventions |
| title_full | Neurological damages in COVID‐19 patients: Mechanisms and preventive interventions |
| title_fullStr | Neurological damages in COVID‐19 patients: Mechanisms and preventive interventions |
| title_full_unstemmed | Neurological damages in COVID‐19 patients: Mechanisms and preventive interventions |
| title_short | Neurological damages in COVID‐19 patients: Mechanisms and preventive interventions |
| title_sort | neurological damages in covid 19 patients mechanisms and preventive interventions |
| topic | antioxidant COVID‐19 ischemia neurological damage prevention therapy ROS |
| url | https://doi.org/10.1002/mco2.247 |
| work_keys_str_mv | AT sibanisarkar neurologicaldamagesincovid19patientsmechanismsandpreventiveinterventions AT subhajitkarmakar neurologicaldamagesincovid19patientsmechanismsandpreventiveinterventions AT malinibasu neurologicaldamagesincovid19patientsmechanismsandpreventiveinterventions AT pratyashaghosh neurologicaldamagesincovid19patientsmechanismsandpreventiveinterventions AT mrinalkghosh neurologicaldamagesincovid19patientsmechanismsandpreventiveinterventions |