Global and population-specific association of MTHFR polymorphisms with preterm birth risk: a consolidated analysis of 44 studies

Global and population-specific association of MTHFR polymorphisms with preterm birth risk: a consolidated analysis of 44 studies

Abstract Background This study investigates the relationship between polymorphisms in the MTHFR gene and the risk of preterm birth (PTB). Methods A comprehensive literature review was conducted using databases such as PubMed, Web of Science, and CNKI, with the search finalized on January 1, 2025. Th...

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Main Authors: Maryam Vafapour, Hanieh Talebi, Mahsa Danaei, Maryam Yeganegi, Sepideh Azizi, Seyed Alireza Dastgheib, Reza Bahrami, Melina Pourkazemi, Fatemeh Jayervand, Amirhossein Shahbazi, Heewa Rashnavadi, Ali Masoudi, Amirmasoud Shiri, Hossein Neamatzadeh
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Pregnancy and Childbirth
Subjects:
Preterm birth
MTHFR gene
Genetic polymorphisms
Ethnic variability
Pregnancy complications
Online Access:https://doi.org/10.1186/s12884-025-07378-6
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