The Serum High-Sensitive C Reactive Protein and Homocysteine Levels to Evaluate the Prognosis of Acute Ischemic Stroke
Ischemic stroke is one of the most common causes of death worldwide and is most often caused by thrombotic processes. We investigated the changes in hsCRP and homocysteine levels, two of these risk factors, during the acute period of ischemic stroke and evaluated the relationship between these le...
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2007/15929 |
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| author | Tahir Yoldas Murat Gonen Ahmet Godekmerdan Fulya Ilhan Ednan Bayram |
| author_facet | Tahir Yoldas Murat Gonen Ahmet Godekmerdan Fulya Ilhan Ednan Bayram |
| author_sort | Tahir Yoldas |
| collection | DOAJ |
| description | Ischemic stroke is one of the most common causes of death worldwide
and is most often caused by thrombotic processes. We investigated the changes in
hsCRP and homocysteine levels, two of these risk factors, during the acute period
of ischemic stroke and evaluated the relationship between these levels and
the short-term prognosis. HsCRP and homocysteine levels were measured at
the 2nd, 5th, and 10th days in forty patients admitted within second of an ischemic
stroke. The clinical status of the patients
was simultaneously evaluated with the Scandinavian stroke scale. The results were
compared with 40 healthy control subjects whose age and sex were matched with
the patients. The mean hsCRP levels of the patients were 9.4±7.0 mg/L on the 2nd day, 11.0±7.4 mg/L on the 5th day, and 9.2±7.0 mg/L on the 10th day. The mean hsCRP level of the control
subjects was 1.7±2.9 mg/L. The mean hsCRP levels of the patients on the 2nd, 5th, and 10th
days were significantly
higher than the control subjects (P<.001).
The patients' mean homocysteine levels were 40.6±9.6μmol/L on the 2nd day, 21.7±11.1μmol/L on the 5th day, and 20.7±9.2μmol/L on the 10th day. The mean homocysteine level of the control
subjects was 11.2±1.1μmol/L. The homocysteine levels of the patients were higher than
the control subjects at all
times (P<.01). In conclusion, patients with stroke have a higher circulating serum
hsCRP and homocysteine levels. Short-term unfavorable prognosis seems
to be associated with
elevated serum hsCRP levels in patients with stroke. Although serum
homocysteine was found to be higher, homocysteine seems not related
to prog nosis. |
| format | Article |
| id | doaj-art-013a48805f8b4f2389519387bdaaa690 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-013a48805f8b4f2389519387bdaaa6902025-02-03T05:54:13ZengWileyMediators of Inflammation0962-93511466-18612007-01-01200710.1155/2007/1592915929The Serum High-Sensitive C Reactive Protein and Homocysteine Levels to Evaluate the Prognosis of Acute Ischemic StrokeTahir Yoldas0Murat Gonen1Ahmet Godekmerdan2Fulya Ilhan3Ednan Bayram4Department of Neurology, Medical Faculty, Firat University, Elazig 23119, TurkeyDepartment of Neurology, Medical Faculty, Firat University, Elazig 23119, TurkeyDepartment of Immunology, Medical Faculty, Firat University, Elazig 23119, TurkeyDepartment of Immunology, Medical Faculty, Firat University, Elazig 23119, TurkeyDepartment of Cardiology, Erzurum Informary Hospital, Erzurum 25100, TurkeyIschemic stroke is one of the most common causes of death worldwide and is most often caused by thrombotic processes. We investigated the changes in hsCRP and homocysteine levels, two of these risk factors, during the acute period of ischemic stroke and evaluated the relationship between these levels and the short-term prognosis. HsCRP and homocysteine levels were measured at the 2nd, 5th, and 10th days in forty patients admitted within second of an ischemic stroke. The clinical status of the patients was simultaneously evaluated with the Scandinavian stroke scale. The results were compared with 40 healthy control subjects whose age and sex were matched with the patients. The mean hsCRP levels of the patients were 9.4±7.0 mg/L on the 2nd day, 11.0±7.4 mg/L on the 5th day, and 9.2±7.0 mg/L on the 10th day. The mean hsCRP level of the control subjects was 1.7±2.9 mg/L. The mean hsCRP levels of the patients on the 2nd, 5th, and 10th days were significantly higher than the control subjects (P<.001). The patients' mean homocysteine levels were 40.6±9.6μmol/L on the 2nd day, 21.7±11.1μmol/L on the 5th day, and 20.7±9.2μmol/L on the 10th day. The mean homocysteine level of the control subjects was 11.2±1.1μmol/L. The homocysteine levels of the patients were higher than the control subjects at all times (P<.01). In conclusion, patients with stroke have a higher circulating serum hsCRP and homocysteine levels. Short-term unfavorable prognosis seems to be associated with elevated serum hsCRP levels in patients with stroke. Although serum homocysteine was found to be higher, homocysteine seems not related to prog nosis.http://dx.doi.org/10.1155/2007/15929 |
| spellingShingle | Tahir Yoldas Murat Gonen Ahmet Godekmerdan Fulya Ilhan Ednan Bayram The Serum High-Sensitive C Reactive Protein and Homocysteine Levels to Evaluate the Prognosis of Acute Ischemic Stroke Mediators of Inflammation |
| title | The Serum High-Sensitive C Reactive Protein and Homocysteine Levels to Evaluate the Prognosis of Acute Ischemic Stroke |
| title_full | The Serum High-Sensitive C Reactive Protein and Homocysteine Levels to Evaluate the Prognosis of Acute Ischemic Stroke |
| title_fullStr | The Serum High-Sensitive C Reactive Protein and Homocysteine Levels to Evaluate the Prognosis of Acute Ischemic Stroke |
| title_full_unstemmed | The Serum High-Sensitive C Reactive Protein and Homocysteine Levels to Evaluate the Prognosis of Acute Ischemic Stroke |
| title_short | The Serum High-Sensitive C Reactive Protein and Homocysteine Levels to Evaluate the Prognosis of Acute Ischemic Stroke |
| title_sort | serum high sensitive c reactive protein and homocysteine levels to evaluate the prognosis of acute ischemic stroke |
| url | http://dx.doi.org/10.1155/2007/15929 |
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