On the Significance of New Biochemical Markers for the Diagnosis of Premature Labour
Preterm labour is defined as a birth taking place between 22nd and 37th weeks of gestation. Despite numerous studies on the aetiology and pathogenesis of preterm labour, its very cause still remains unclear. The importance of the cytokines and acute inflammation in preterm labour aetiology is nowada...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/251451 |
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| _version_ | 1832555898454671360 |
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| author | Rafał Rzepka Barbara Dołęgowska Aleksandra Rajewska Sebastian Kwiatkowski |
| author_facet | Rafał Rzepka Barbara Dołęgowska Aleksandra Rajewska Sebastian Kwiatkowski |
| author_sort | Rafał Rzepka |
| collection | DOAJ |
| description | Preterm labour is defined as a birth taking place between 22nd and 37th weeks of gestation. Despite numerous studies on the aetiology and pathogenesis of preterm labour, its very cause still remains unclear. The importance of the cytokines and acute inflammation in preterm labour aetiology is nowadays well-proven. However, chronic inflammation as an element of the pathogenesis of premature labour is still unclear. This paper presents a literature review on the damage-associated molecular patterns (DAMPs), receptors for advanced glycation end products (RAGE), negative soluble isoforms of RAGE, chemokine-stromal cell-derived factor-1 (SDF-1) and one of the adipokines, resistin, in the pathogenesis of preterm labour. We conclude that the chronic inflammatory response can play a much more important role in the pathogenesis of preterm delivery than the acute one. |
| format | Article |
| id | doaj-art-012efd9854284e9f84e2b28820b9a8d1 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-012efd9854284e9f84e2b28820b9a8d12025-02-03T05:46:46ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/251451251451On the Significance of New Biochemical Markers for the Diagnosis of Premature LabourRafał Rzepka0Barbara Dołęgowska1Aleksandra Rajewska2Sebastian Kwiatkowski3Department of Obstetrics and Gynecology, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Laboratory Diagnostics and Molecular Medicine, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Obstetrics and Gynecology, Pomeranian Medical University, 70-111 Szczecin, PolandDepartment of Obstetrics and Gynecology, Pomeranian Medical University, 70-111 Szczecin, PolandPreterm labour is defined as a birth taking place between 22nd and 37th weeks of gestation. Despite numerous studies on the aetiology and pathogenesis of preterm labour, its very cause still remains unclear. The importance of the cytokines and acute inflammation in preterm labour aetiology is nowadays well-proven. However, chronic inflammation as an element of the pathogenesis of premature labour is still unclear. This paper presents a literature review on the damage-associated molecular patterns (DAMPs), receptors for advanced glycation end products (RAGE), negative soluble isoforms of RAGE, chemokine-stromal cell-derived factor-1 (SDF-1) and one of the adipokines, resistin, in the pathogenesis of preterm labour. We conclude that the chronic inflammatory response can play a much more important role in the pathogenesis of preterm delivery than the acute one.http://dx.doi.org/10.1155/2014/251451 |
| spellingShingle | Rafał Rzepka Barbara Dołęgowska Aleksandra Rajewska Sebastian Kwiatkowski On the Significance of New Biochemical Markers for the Diagnosis of Premature Labour Mediators of Inflammation |
| title | On the Significance of New Biochemical Markers for the Diagnosis of Premature Labour |
| title_full | On the Significance of New Biochemical Markers for the Diagnosis of Premature Labour |
| title_fullStr | On the Significance of New Biochemical Markers for the Diagnosis of Premature Labour |
| title_full_unstemmed | On the Significance of New Biochemical Markers for the Diagnosis of Premature Labour |
| title_short | On the Significance of New Biochemical Markers for the Diagnosis of Premature Labour |
| title_sort | on the significance of new biochemical markers for the diagnosis of premature labour |
| url | http://dx.doi.org/10.1155/2014/251451 |
| work_keys_str_mv | AT rafałrzepka onthesignificanceofnewbiochemicalmarkersforthediagnosisofprematurelabour AT barbaradołegowska onthesignificanceofnewbiochemicalmarkersforthediagnosisofprematurelabour AT aleksandrarajewska onthesignificanceofnewbiochemicalmarkersforthediagnosisofprematurelabour AT sebastiankwiatkowski onthesignificanceofnewbiochemicalmarkersforthediagnosisofprematurelabour |