Analysis of gastric and duodenal biopsy results in patients presenting with dyspepsia: a cross-sectional study in a middle eastern population
Objective Correa’s cascade is a ‘Model for Gastric Cancer Development’ described by Peleyo Correa. The reversibility of Correa’s cascade remains debatable. The literature contains insufficient data on the specific stage of the cascade during which Helicobacter pylori is detected, treated, and the ef...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2019-09-01
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| Series: | BMJ Open Gastroenterology |
| Online Access: | https://bmjopengastro.bmj.com/content/6/1/e000330.full |
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| author | Mohammed Hussein Kamareddine Youssef Ghosn Naseem Bou-Ayash Said Farhat Antonios Tawk Haneen Bou-Ayash Nader Mokamer Rawad Yared Mouna Aoun Salem Khoury George Cortas Gide Jabbour Khalil Bedran |
| author_facet | Mohammed Hussein Kamareddine Youssef Ghosn Naseem Bou-Ayash Said Farhat Antonios Tawk Haneen Bou-Ayash Nader Mokamer Rawad Yared Mouna Aoun Salem Khoury George Cortas Gide Jabbour Khalil Bedran |
| author_sort | Mohammed Hussein Kamareddine |
| collection | DOAJ |
| description | Objective Correa’s cascade is a ‘Model for Gastric Cancer Development’ described by Peleyo Correa. The reversibility of Correa’s cascade remains debatable. The literature contains insufficient data on the specific stage of the cascade during which Helicobacter pylori is detected, treated, and the effect on prognosis. Herein, we aim to determine the prevalence of various precancerous and cancerous gastric lesions in patients presenting with dyspepsia, the prevalence of gastritis and H. pylori infection, the prevalence of duodenal pathology in patients presenting with dyspepsia, identify the stage of H. pylori detection in relation to Correa’s cascade, and investigate a possible relationship between H. pylori and celiac disease.Design Retrospective cross-sectional study conducted on a middle eastern population at a Lebanese tertiary hospital centre. 1428 patients presenting with dyspepsia underwent gastroscopy with gastric and duodenal biopsies. Variables include age, sex, presence/absence of H. pylori infection, and histopathological analysis of gastric and duodenal biopsies.Results Being above 40 years of age was associated with increased likelihood of exhibiting abnormal gastric biopsy result. Gastritis and metaplasia were detected more frequently than glandular atrophy (p<0.001) with gastritis being present the most (p<0.001). The presence of H. pylori and the gastric biopsy results were not associated with any of the duodenal biopsy results.Conclusion The burden of H. pylori infection in patients with dyspepsia was high. H. pylori was detected at various precancerous lesions with varying significance. The prevalence of duodenal adenocarcinoma in dyspeptic patients is unexpectedly high. No association between gastric and duodenal pathologies was found. |
| format | Article |
| id | doaj-art-012eee4e8bcd4e4291d6b8ae4268a3ab |
| institution | OA Journals |
| issn | 2054-4774 |
| language | English |
| publishDate | 2019-09-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Gastroenterology |
| spelling | doaj-art-012eee4e8bcd4e4291d6b8ae4268a3ab2025-08-20T02:08:43ZengBMJ Publishing GroupBMJ Open Gastroenterology2054-47742019-09-016110.1136/bmjgast-2019-000330Analysis of gastric and duodenal biopsy results in patients presenting with dyspepsia: a cross-sectional study in a middle eastern populationMohammed Hussein Kamareddine0Youssef Ghosn1Naseem Bou-Ayash2Said Farhat3Antonios Tawk4Haneen Bou-Ayash5Nader Mokamer6Rawad Yared7Mouna Aoun8Salem Khoury9George Cortas10Gide Jabbour11Khalil Bedran12Faculty of Medicine and Medical Sciences, University of Balamand, El-Koura, LebanonFaculty of Medicine and Medical Sciences, University of Balamand, El-Koura, LebanonFaculty of Medicine and Medical Sciences, University of Balamand, El-Koura, LebanonFaculty of Medicine and Medical Sciences, University of Balamand, El-Koura, LebanonFaculty of Medicine and Medical Sciences, University of Balamand, El-Koura, LebanonFaculty of Health and Health Sciences, American University of Beirut, Beirut, LebanonFaculty of Medicine and Medical Sciences, University of Balamand, El-Koura, LebanonSaint George Hospital University Medical Center, Beirut, LebanonSaint George Hospital University Medical Center, Beirut, LebanonSaint George Hospital University Medical Center, Beirut, LebanonSaint George Hospital University Medical Center, Beirut, LebanonSaint George Hospital University Medical Center, Beirut, LebanonSaint George Hospital University Medical Center, Beirut, LebanonObjective Correa’s cascade is a ‘Model for Gastric Cancer Development’ described by Peleyo Correa. The reversibility of Correa’s cascade remains debatable. The literature contains insufficient data on the specific stage of the cascade during which Helicobacter pylori is detected, treated, and the effect on prognosis. Herein, we aim to determine the prevalence of various precancerous and cancerous gastric lesions in patients presenting with dyspepsia, the prevalence of gastritis and H. pylori infection, the prevalence of duodenal pathology in patients presenting with dyspepsia, identify the stage of H. pylori detection in relation to Correa’s cascade, and investigate a possible relationship between H. pylori and celiac disease.Design Retrospective cross-sectional study conducted on a middle eastern population at a Lebanese tertiary hospital centre. 1428 patients presenting with dyspepsia underwent gastroscopy with gastric and duodenal biopsies. Variables include age, sex, presence/absence of H. pylori infection, and histopathological analysis of gastric and duodenal biopsies.Results Being above 40 years of age was associated with increased likelihood of exhibiting abnormal gastric biopsy result. Gastritis and metaplasia were detected more frequently than glandular atrophy (p<0.001) with gastritis being present the most (p<0.001). The presence of H. pylori and the gastric biopsy results were not associated with any of the duodenal biopsy results.Conclusion The burden of H. pylori infection in patients with dyspepsia was high. H. pylori was detected at various precancerous lesions with varying significance. The prevalence of duodenal adenocarcinoma in dyspeptic patients is unexpectedly high. No association between gastric and duodenal pathologies was found.https://bmjopengastro.bmj.com/content/6/1/e000330.full |
| spellingShingle | Mohammed Hussein Kamareddine Youssef Ghosn Naseem Bou-Ayash Said Farhat Antonios Tawk Haneen Bou-Ayash Nader Mokamer Rawad Yared Mouna Aoun Salem Khoury George Cortas Gide Jabbour Khalil Bedran Analysis of gastric and duodenal biopsy results in patients presenting with dyspepsia: a cross-sectional study in a middle eastern population BMJ Open Gastroenterology |
| title | Analysis of gastric and duodenal biopsy results in patients presenting with dyspepsia: a cross-sectional study in a middle eastern population |
| title_full | Analysis of gastric and duodenal biopsy results in patients presenting with dyspepsia: a cross-sectional study in a middle eastern population |
| title_fullStr | Analysis of gastric and duodenal biopsy results in patients presenting with dyspepsia: a cross-sectional study in a middle eastern population |
| title_full_unstemmed | Analysis of gastric and duodenal biopsy results in patients presenting with dyspepsia: a cross-sectional study in a middle eastern population |
| title_short | Analysis of gastric and duodenal biopsy results in patients presenting with dyspepsia: a cross-sectional study in a middle eastern population |
| title_sort | analysis of gastric and duodenal biopsy results in patients presenting with dyspepsia a cross sectional study in a middle eastern population |
| url | https://bmjopengastro.bmj.com/content/6/1/e000330.full |
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