Ferroptosis Is a Potential Therapeutic Target for Pulmonary Infectious Diseases
Ferroptosis is a new type of iron-dependent cell death caused by lipid peroxide (LPO) accumulation and involved in disease of pulmonary infection. The dysregulation of iron metabolism, the accumulation of LPO, and the inactivation and consumption of glutathione peroxidase 4 (GPX4) are the crucial ca...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Cellular Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2023/3875897 |
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| _version_ | 1832559668396818432 |
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| author | Yurong Zhang Dianlun Qian Xiangfeng Bai Shibo Sun |
| author_facet | Yurong Zhang Dianlun Qian Xiangfeng Bai Shibo Sun |
| author_sort | Yurong Zhang |
| collection | DOAJ |
| description | Ferroptosis is a new type of iron-dependent cell death caused by lipid peroxide (LPO) accumulation and involved in disease of pulmonary infection. The dysregulation of iron metabolism, the accumulation of LPO, and the inactivation and consumption of glutathione peroxidase 4 (GPX4) are the crucial cause of ferroptosis. Pulmonary infectious diseases caused by Pseudomonas aeruginosa (PA), Mycobacterium tuberculosis (MTB), and severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) are associated with ferroptosis. Ferroptosis may be a potential therapeutic target for pulmonary infectious diseases. However, the mechanisms by which these infections are involved in ferroptosis and whether pulmonary infectious diseases caused by Staphylococcus aureus, Klebsiella pneumoniae, and Leishmania spp are related to ferroptosis are unclear. Accordingly, more researches are needed. |
| format | Article |
| id | doaj-art-012a97379b59488ab9a8870f88eadf8e |
| institution | Kabale University |
| issn | 1462-5822 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cellular Microbiology |
| spelling | doaj-art-012a97379b59488ab9a8870f88eadf8e2025-02-03T01:29:28ZengWileyCellular Microbiology1462-58222023-01-01202310.1155/2023/3875897Ferroptosis Is a Potential Therapeutic Target for Pulmonary Infectious DiseasesYurong Zhang0Dianlun Qian1Xiangfeng Bai2Shibo Sun3Department of Pulmonary and Critical Care MedicineDepartment of CardiologyDepartment of CardiologyDepartment of Pulmonary and Critical Care MedicineFerroptosis is a new type of iron-dependent cell death caused by lipid peroxide (LPO) accumulation and involved in disease of pulmonary infection. The dysregulation of iron metabolism, the accumulation of LPO, and the inactivation and consumption of glutathione peroxidase 4 (GPX4) are the crucial cause of ferroptosis. Pulmonary infectious diseases caused by Pseudomonas aeruginosa (PA), Mycobacterium tuberculosis (MTB), and severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) are associated with ferroptosis. Ferroptosis may be a potential therapeutic target for pulmonary infectious diseases. However, the mechanisms by which these infections are involved in ferroptosis and whether pulmonary infectious diseases caused by Staphylococcus aureus, Klebsiella pneumoniae, and Leishmania spp are related to ferroptosis are unclear. Accordingly, more researches are needed.http://dx.doi.org/10.1155/2023/3875897 |
| spellingShingle | Yurong Zhang Dianlun Qian Xiangfeng Bai Shibo Sun Ferroptosis Is a Potential Therapeutic Target for Pulmonary Infectious Diseases Cellular Microbiology |
| title | Ferroptosis Is a Potential Therapeutic Target for Pulmonary Infectious Diseases |
| title_full | Ferroptosis Is a Potential Therapeutic Target for Pulmonary Infectious Diseases |
| title_fullStr | Ferroptosis Is a Potential Therapeutic Target for Pulmonary Infectious Diseases |
| title_full_unstemmed | Ferroptosis Is a Potential Therapeutic Target for Pulmonary Infectious Diseases |
| title_short | Ferroptosis Is a Potential Therapeutic Target for Pulmonary Infectious Diseases |
| title_sort | ferroptosis is a potential therapeutic target for pulmonary infectious diseases |
| url | http://dx.doi.org/10.1155/2023/3875897 |
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