Therapeutic Endoscopic Ultrasonography: Intratumoral Injection for Pancreatic Adenocarcinoma
Pancreatic adenocarcinoma is an aggressive disease that has poor outcomes despite maximal traditional therapies. Thus, treatment of this cancer demands innovative strategies to be used in addition to standing therapies in order to provide new avenues of care. Here, we describe the technique of using...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/207129 |
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| _version_ | 1832563333457248256 |
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| author | Lawrence A. Shirley Laura K. Aguilar Estuardo Aguilar-Cordova Mark Bloomston Jon P. Walker |
| author_facet | Lawrence A. Shirley Laura K. Aguilar Estuardo Aguilar-Cordova Mark Bloomston Jon P. Walker |
| author_sort | Lawrence A. Shirley |
| collection | DOAJ |
| description | Pancreatic adenocarcinoma is an aggressive disease that has poor outcomes despite maximal traditional therapies. Thus, treatment of this cancer demands innovative strategies to be used in addition to standing therapies in order to provide new avenues of care. Here, we describe the technique of using endoscopic ultrasound in order to directly inject both novel and conventional therapies into pancreatic tumors. We detail the rationale behind this strategy and the many benefits it provides. We then describe our technique in detail, including our experience injecting the AdV-tk adenoviral vector to create an in situ vaccine effect. |
| format | Article |
| id | doaj-art-0123f03e49ba4e228f2f224ed1c19179 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-0123f03e49ba4e228f2f224ed1c191792025-02-03T01:20:22ZengWileyGastroenterology Research and Practice1687-61211687-630X2013-01-01201310.1155/2013/207129207129Therapeutic Endoscopic Ultrasonography: Intratumoral Injection for Pancreatic AdenocarcinomaLawrence A. Shirley0Laura K. Aguilar1Estuardo Aguilar-Cordova2Mark Bloomston3Jon P. Walker4Division of Surgical Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USAAdvantagene, Inc., Auburndale, MA 02466, USAAdvantagene, Inc., Auburndale, MA 02466, USADivision of Surgical Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USADivision of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH 43210-1267, USAPancreatic adenocarcinoma is an aggressive disease that has poor outcomes despite maximal traditional therapies. Thus, treatment of this cancer demands innovative strategies to be used in addition to standing therapies in order to provide new avenues of care. Here, we describe the technique of using endoscopic ultrasound in order to directly inject both novel and conventional therapies into pancreatic tumors. We detail the rationale behind this strategy and the many benefits it provides. We then describe our technique in detail, including our experience injecting the AdV-tk adenoviral vector to create an in situ vaccine effect.http://dx.doi.org/10.1155/2013/207129 |
| spellingShingle | Lawrence A. Shirley Laura K. Aguilar Estuardo Aguilar-Cordova Mark Bloomston Jon P. Walker Therapeutic Endoscopic Ultrasonography: Intratumoral Injection for Pancreatic Adenocarcinoma Gastroenterology Research and Practice |
| title | Therapeutic Endoscopic Ultrasonography: Intratumoral Injection for Pancreatic Adenocarcinoma |
| title_full | Therapeutic Endoscopic Ultrasonography: Intratumoral Injection for Pancreatic Adenocarcinoma |
| title_fullStr | Therapeutic Endoscopic Ultrasonography: Intratumoral Injection for Pancreatic Adenocarcinoma |
| title_full_unstemmed | Therapeutic Endoscopic Ultrasonography: Intratumoral Injection for Pancreatic Adenocarcinoma |
| title_short | Therapeutic Endoscopic Ultrasonography: Intratumoral Injection for Pancreatic Adenocarcinoma |
| title_sort | therapeutic endoscopic ultrasonography intratumoral injection for pancreatic adenocarcinoma |
| url | http://dx.doi.org/10.1155/2013/207129 |
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