Phytochemical and Metabolomic Investigation of a Popular Traditional Plant from La Réunion: <i>Psiloxylon mauritianum</i>
A molecular network investigation of <i>Psiloxylon mauritianum</i> leaf extracts from five different specimens led to the detection of a diversity of flavonoids, triterpenes, and phloroglucinols. Some compounds from these molecular classes are reported to target fever-linked symptoms (an...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Applied Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3417/15/2/496 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832589231708438528 |
|---|---|
| author | Théo Ozga Gaëtan Herbette Patrick Carriere Richez Patricia Clerc Juliano Haddad Chaker El Kalamouni Jérôme Bignon Rémy Marcellin-Gros Emerson Ferreira Queiroz Jean-Luc Wolfender Jacqueline Smadja Anne Gauvin-Bialecki |
| author_facet | Théo Ozga Gaëtan Herbette Patrick Carriere Richez Patricia Clerc Juliano Haddad Chaker El Kalamouni Jérôme Bignon Rémy Marcellin-Gros Emerson Ferreira Queiroz Jean-Luc Wolfender Jacqueline Smadja Anne Gauvin-Bialecki |
| author_sort | Théo Ozga |
| collection | DOAJ |
| description | A molecular network investigation of <i>Psiloxylon mauritianum</i> leaf extracts from five different specimens led to the detection of a diversity of flavonoids, triterpenes, and phloroglucinols. Some compounds from these molecular classes are reported to target fever-linked symptoms (antioxidant, antiviral, anti-inflammatory, and antibacterial activities) and may explain the plant’s success as a local traditional remedy. The phytochemical study of one extract allowed the isolation and characterization of an original seco-ring-A lupane structurally similar to the anti-inflammatory betulinic acid, 11 known triterpenes, 2 flavonoids, and a chalcone. Antiviral assays highlighted the in vitro anti-Zika activity of corosolic and betulinic acids found in the plant. Some interesting structure–activity relationships could be drawn between the new compound and the known active triterpenes. |
| format | Article |
| id | doaj-art-01204d58fdc54a07a51af2b95aacc8e8 |
| institution | Kabale University |
| issn | 2076-3417 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj-art-01204d58fdc54a07a51af2b95aacc8e82025-01-24T13:19:34ZengMDPI AGApplied Sciences2076-34172025-01-0115249610.3390/app15020496Phytochemical and Metabolomic Investigation of a Popular Traditional Plant from La Réunion: <i>Psiloxylon mauritianum</i>Théo Ozga0Gaëtan Herbette1Patrick Carriere Richez2Patricia Clerc3Juliano Haddad4Chaker El Kalamouni5Jérôme Bignon6Rémy Marcellin-Gros7Emerson Ferreira Queiroz8Jean-Luc Wolfender9Jacqueline Smadja10Anne Gauvin-Bialecki11Laboratoire de Chimie et de Biotechnologie des Produits Naturels, Faculté des Sciences et Technologies, Université de La Réunion, 15 Avenue René Cassin, CS92003, CEDEX 9, 97744 Saint-Denis, FranceSpectropole, FSCM, Centrale Méditerrané, CNRS, Aix-Marseille Université, Campus de Saint-Jérôme Service 511, 13397 Marseille, FranceLaboratoire de Chimie et de Biotechnologie des Produits Naturels, Faculté des Sciences et Technologies, Université de La Réunion, 15 Avenue René Cassin, CS92003, CEDEX 9, 97744 Saint-Denis, FranceLaboratoire de Chimie et de Biotechnologie des Produits Naturels, Faculté des Sciences et Technologies, Université de La Réunion, 15 Avenue René Cassin, CS92003, CEDEX 9, 97744 Saint-Denis, FranceUnité Mixte Processus Infectieux en Milieu Insulaire Tropical, Université de la Réunion, INSERM U1187, CNRS UMR 9192, IRD UMR 249, Plateforme Technologique CYROI, 97490 Sainte Clotilde, FranceUnité Mixte Processus Infectieux en Milieu Insulaire Tropical, Université de la Réunion, INSERM U1187, CNRS UMR 9192, IRD UMR 249, Plateforme Technologique CYROI, 97490 Sainte Clotilde, FranceInstitut de Chimie des Substances Naturelles (ICSN), CNRS UPR 2301, Université Paris Saclay, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette, FranceInstitute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Centre Médical Universitaire, Rue Michel Servet 1, 1206 Geneva, SwitzerlandInstitute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Centre Médical Universitaire, Rue Michel Servet 1, 1206 Geneva, SwitzerlandInstitute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Centre Médical Universitaire, Rue Michel Servet 1, 1206 Geneva, SwitzerlandLaboratoire de Chimie et de Biotechnologie des Produits Naturels, Faculté des Sciences et Technologies, Université de La Réunion, 15 Avenue René Cassin, CS92003, CEDEX 9, 97744 Saint-Denis, FranceLaboratoire de Chimie et de Biotechnologie des Produits Naturels, Faculté des Sciences et Technologies, Université de La Réunion, 15 Avenue René Cassin, CS92003, CEDEX 9, 97744 Saint-Denis, FranceA molecular network investigation of <i>Psiloxylon mauritianum</i> leaf extracts from five different specimens led to the detection of a diversity of flavonoids, triterpenes, and phloroglucinols. Some compounds from these molecular classes are reported to target fever-linked symptoms (antioxidant, antiviral, anti-inflammatory, and antibacterial activities) and may explain the plant’s success as a local traditional remedy. The phytochemical study of one extract allowed the isolation and characterization of an original seco-ring-A lupane structurally similar to the anti-inflammatory betulinic acid, 11 known triterpenes, 2 flavonoids, and a chalcone. Antiviral assays highlighted the in vitro anti-Zika activity of corosolic and betulinic acids found in the plant. Some interesting structure–activity relationships could be drawn between the new compound and the known active triterpenes.https://www.mdpi.com/2076-3417/15/2/496plant secondary metabolites<i>Psiloxylon mauritianum</i>traditional remedytriterpenesantiviral testsmolecular networks |
| spellingShingle | Théo Ozga Gaëtan Herbette Patrick Carriere Richez Patricia Clerc Juliano Haddad Chaker El Kalamouni Jérôme Bignon Rémy Marcellin-Gros Emerson Ferreira Queiroz Jean-Luc Wolfender Jacqueline Smadja Anne Gauvin-Bialecki Phytochemical and Metabolomic Investigation of a Popular Traditional Plant from La Réunion: <i>Psiloxylon mauritianum</i> Applied Sciences plant secondary metabolites <i>Psiloxylon mauritianum</i> traditional remedy triterpenes antiviral tests molecular networks |
| title | Phytochemical and Metabolomic Investigation of a Popular Traditional Plant from La Réunion: <i>Psiloxylon mauritianum</i> |
| title_full | Phytochemical and Metabolomic Investigation of a Popular Traditional Plant from La Réunion: <i>Psiloxylon mauritianum</i> |
| title_fullStr | Phytochemical and Metabolomic Investigation of a Popular Traditional Plant from La Réunion: <i>Psiloxylon mauritianum</i> |
| title_full_unstemmed | Phytochemical and Metabolomic Investigation of a Popular Traditional Plant from La Réunion: <i>Psiloxylon mauritianum</i> |
| title_short | Phytochemical and Metabolomic Investigation of a Popular Traditional Plant from La Réunion: <i>Psiloxylon mauritianum</i> |
| title_sort | phytochemical and metabolomic investigation of a popular traditional plant from la reunion i psiloxylon mauritianum i |
| topic | plant secondary metabolites <i>Psiloxylon mauritianum</i> traditional remedy triterpenes antiviral tests molecular networks |
| url | https://www.mdpi.com/2076-3417/15/2/496 |
| work_keys_str_mv | AT theoozga phytochemicalandmetabolomicinvestigationofapopulartraditionalplantfromlareunionipsiloxylonmauritianumi AT gaetanherbette phytochemicalandmetabolomicinvestigationofapopulartraditionalplantfromlareunionipsiloxylonmauritianumi AT patrickcarriererichez phytochemicalandmetabolomicinvestigationofapopulartraditionalplantfromlareunionipsiloxylonmauritianumi AT patriciaclerc phytochemicalandmetabolomicinvestigationofapopulartraditionalplantfromlareunionipsiloxylonmauritianumi AT julianohaddad phytochemicalandmetabolomicinvestigationofapopulartraditionalplantfromlareunionipsiloxylonmauritianumi AT chakerelkalamouni phytochemicalandmetabolomicinvestigationofapopulartraditionalplantfromlareunionipsiloxylonmauritianumi AT jeromebignon phytochemicalandmetabolomicinvestigationofapopulartraditionalplantfromlareunionipsiloxylonmauritianumi AT remymarcellingros phytochemicalandmetabolomicinvestigationofapopulartraditionalplantfromlareunionipsiloxylonmauritianumi AT emersonferreiraqueiroz phytochemicalandmetabolomicinvestigationofapopulartraditionalplantfromlareunionipsiloxylonmauritianumi AT jeanlucwolfender phytochemicalandmetabolomicinvestigationofapopulartraditionalplantfromlareunionipsiloxylonmauritianumi AT jacquelinesmadja phytochemicalandmetabolomicinvestigationofapopulartraditionalplantfromlareunionipsiloxylonmauritianumi AT annegauvinbialecki phytochemicalandmetabolomicinvestigationofapopulartraditionalplantfromlareunionipsiloxylonmauritianumi |