Evaluation of Salivary and Serum Total Antioxidant Capacity and Lipid Peroxidation in Postmenopausal Women
Objective. In menopause, reduction of estrogen hormone affects oxidative stress process in serum. Oxidative stress in saliva plays a significant role in the pathogenesis of oral diseases. The aim of this study was to investigate the total antioxidant capacity and lipid peroxidation in the serum and...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2020/8860467 |
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| author | Fatemeh Zovari Hadi Parsian Ali Bijani Ameneh Moslemnezhad Atena Shirzad |
| author_facet | Fatemeh Zovari Hadi Parsian Ali Bijani Ameneh Moslemnezhad Atena Shirzad |
| author_sort | Fatemeh Zovari |
| collection | DOAJ |
| description | Objective. In menopause, reduction of estrogen hormone affects oxidative stress process in serum. Oxidative stress in saliva plays a significant role in the pathogenesis of oral diseases. The aim of this study was to investigate the total antioxidant capacity and lipid peroxidation in the serum and saliva of premenopausal and postmenopausal women. Methods. In this case control study, 50 postmenopausal women (case group) and 48 premenopausal women (control group) were selected. The unstimulated whole saliva and serum of the postmenopausal and premenopausal women were collected. The total antioxidant capacity (TAC) of the saliva and serum was measured by ferric reducing antioxidant power (FRAP). Also, malondialdehyde (MDA) was measured by thiobarbituric acid reactive substance (TBARS) method for serum and saliva. Then, the obtained data were analyzed by SPSS 17, whereby Mann–Whitney test and Spearman’s correlation test were used. P<0.05 was considered statistically significant. Results. The postmenopausal group had significantly lower mean serum TAC and higher mean serum MDA than the control group (P<0<001 and P<0.01, respectively). The mean salivary TAC and MDA, however, did not differ significantly between the case and control group (P=0.64 and P=0.08, respectively). Conclusion. In postmenopausal women, with elevation of serum MDA and reduction of serum TAC, the extent of serum oxidative stress grows, but MDA and TAC levels of saliva do not change. |
| format | Article |
| id | doaj-art-010e5b76b1444c0f973f787a8f1f0973 |
| institution | Kabale University |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-010e5b76b1444c0f973f787a8f1f09732025-02-03T01:05:10ZengWileyInternational Journal of Dentistry1687-87281687-87362020-01-01202010.1155/2020/88604678860467Evaluation of Salivary and Serum Total Antioxidant Capacity and Lipid Peroxidation in Postmenopausal WomenFatemeh Zovari0Hadi Parsian1Ali Bijani2Ameneh Moslemnezhad3Atena Shirzad4Research Committee, Babol University of Medical Sciences, Babol, IranDepartment of Biochemistry, School of Sciences, Babol University of Medical Sciences, Babol, IranSocial Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IranDepartment of Clinical Biochemistry, Facility of Medicine, Babol University of Medical Sciences, Babol, IranOral Health Research Center, Babol University of Medical Sciences, Babol, IranObjective. In menopause, reduction of estrogen hormone affects oxidative stress process in serum. Oxidative stress in saliva plays a significant role in the pathogenesis of oral diseases. The aim of this study was to investigate the total antioxidant capacity and lipid peroxidation in the serum and saliva of premenopausal and postmenopausal women. Methods. In this case control study, 50 postmenopausal women (case group) and 48 premenopausal women (control group) were selected. The unstimulated whole saliva and serum of the postmenopausal and premenopausal women were collected. The total antioxidant capacity (TAC) of the saliva and serum was measured by ferric reducing antioxidant power (FRAP). Also, malondialdehyde (MDA) was measured by thiobarbituric acid reactive substance (TBARS) method for serum and saliva. Then, the obtained data were analyzed by SPSS 17, whereby Mann–Whitney test and Spearman’s correlation test were used. P<0.05 was considered statistically significant. Results. The postmenopausal group had significantly lower mean serum TAC and higher mean serum MDA than the control group (P<0<001 and P<0.01, respectively). The mean salivary TAC and MDA, however, did not differ significantly between the case and control group (P=0.64 and P=0.08, respectively). Conclusion. In postmenopausal women, with elevation of serum MDA and reduction of serum TAC, the extent of serum oxidative stress grows, but MDA and TAC levels of saliva do not change.http://dx.doi.org/10.1155/2020/8860467 |
| spellingShingle | Fatemeh Zovari Hadi Parsian Ali Bijani Ameneh Moslemnezhad Atena Shirzad Evaluation of Salivary and Serum Total Antioxidant Capacity and Lipid Peroxidation in Postmenopausal Women International Journal of Dentistry |
| title | Evaluation of Salivary and Serum Total Antioxidant Capacity and Lipid Peroxidation in Postmenopausal Women |
| title_full | Evaluation of Salivary and Serum Total Antioxidant Capacity and Lipid Peroxidation in Postmenopausal Women |
| title_fullStr | Evaluation of Salivary and Serum Total Antioxidant Capacity and Lipid Peroxidation in Postmenopausal Women |
| title_full_unstemmed | Evaluation of Salivary and Serum Total Antioxidant Capacity and Lipid Peroxidation in Postmenopausal Women |
| title_short | Evaluation of Salivary and Serum Total Antioxidant Capacity and Lipid Peroxidation in Postmenopausal Women |
| title_sort | evaluation of salivary and serum total antioxidant capacity and lipid peroxidation in postmenopausal women |
| url | http://dx.doi.org/10.1155/2020/8860467 |
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