Altered Structural and Functional Connectivity of Juvenile Myoclonic Epilepsy: An fMRI Study
The aim of this study was to investigate the structural and functional connectivity (FC) of juvenile myoclonic epilepsy (JME) using resting state functional magnetic resonance imaging (rs-fMRI). High-resolution T1-weighted magnetic resonance imaging (MRI) and rs-fMRI data were collected in 25 patien...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2018/7392187 |
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| author | Chengqing Zhong Rong Liu Cheng Luo Sisi Jiang Li Dong Rui Peng Fuqiang Guo Pu Wang |
| author_facet | Chengqing Zhong Rong Liu Cheng Luo Sisi Jiang Li Dong Rui Peng Fuqiang Guo Pu Wang |
| author_sort | Chengqing Zhong |
| collection | DOAJ |
| description | The aim of this study was to investigate the structural and functional connectivity (FC) of juvenile myoclonic epilepsy (JME) using resting state functional magnetic resonance imaging (rs-fMRI). High-resolution T1-weighted magnetic resonance imaging (MRI) and rs-fMRI data were collected in 25 patients with JME and in 24 control subjects. A FC analysis was subsequently performed, with seeding at the regions that demonstrated between-group differences in gray matter volume (GMV). Then, the observed structural and FCs were associated with the clinical manifestations. The decreased GMV regions were found in the bilateral anterior cerebellum, the right orbital superior frontal gyrus, the left middle temporal gyrus, the left putamen, the right hippocampus, the bilateral caudate, and the right thalamus. The changed FCs were mainly observed in the motor-related areas and the cognitive-related areas. The significant findings of this study revealed an important role for the cerebellum in motor control and cognitive regulation in JME patients, which also have an effect on the activity of the occipital lobe. In addition, the changed FCs were related to the clinical features of JME patients. The current observations may contribute to the understanding of the pathogenesis of JME. |
| format | Article |
| id | doaj-art-0109878acd704889bfa5fe8e0a095363 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-0109878acd704889bfa5fe8e0a0953632025-02-03T01:10:47ZengWileyNeural Plasticity2090-59041687-54432018-01-01201810.1155/2018/73921877392187Altered Structural and Functional Connectivity of Juvenile Myoclonic Epilepsy: An fMRI StudyChengqing Zhong0Rong Liu1Cheng Luo2Sisi Jiang3Li Dong4Rui Peng5Fuqiang Guo6Pu Wang7The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, ChinaDepartment of Neurology, The 452nd Hospital of PLA, Chengdu, Sichuan, ChinaKey Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, ChinaKey Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, ChinaKey Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, ChinaKey Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, ChinaThe Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, ChinaDepartment of Neurology, Chongzhou People’s Hospital, Chongzhou, Sichuan, ChinaThe aim of this study was to investigate the structural and functional connectivity (FC) of juvenile myoclonic epilepsy (JME) using resting state functional magnetic resonance imaging (rs-fMRI). High-resolution T1-weighted magnetic resonance imaging (MRI) and rs-fMRI data were collected in 25 patients with JME and in 24 control subjects. A FC analysis was subsequently performed, with seeding at the regions that demonstrated between-group differences in gray matter volume (GMV). Then, the observed structural and FCs were associated with the clinical manifestations. The decreased GMV regions were found in the bilateral anterior cerebellum, the right orbital superior frontal gyrus, the left middle temporal gyrus, the left putamen, the right hippocampus, the bilateral caudate, and the right thalamus. The changed FCs were mainly observed in the motor-related areas and the cognitive-related areas. The significant findings of this study revealed an important role for the cerebellum in motor control and cognitive regulation in JME patients, which also have an effect on the activity of the occipital lobe. In addition, the changed FCs were related to the clinical features of JME patients. The current observations may contribute to the understanding of the pathogenesis of JME.http://dx.doi.org/10.1155/2018/7392187 |
| spellingShingle | Chengqing Zhong Rong Liu Cheng Luo Sisi Jiang Li Dong Rui Peng Fuqiang Guo Pu Wang Altered Structural and Functional Connectivity of Juvenile Myoclonic Epilepsy: An fMRI Study Neural Plasticity |
| title | Altered Structural and Functional Connectivity of Juvenile Myoclonic Epilepsy: An fMRI Study |
| title_full | Altered Structural and Functional Connectivity of Juvenile Myoclonic Epilepsy: An fMRI Study |
| title_fullStr | Altered Structural and Functional Connectivity of Juvenile Myoclonic Epilepsy: An fMRI Study |
| title_full_unstemmed | Altered Structural and Functional Connectivity of Juvenile Myoclonic Epilepsy: An fMRI Study |
| title_short | Altered Structural and Functional Connectivity of Juvenile Myoclonic Epilepsy: An fMRI Study |
| title_sort | altered structural and functional connectivity of juvenile myoclonic epilepsy an fmri study |
| url | http://dx.doi.org/10.1155/2018/7392187 |
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