A novel approach for target deconvolution from phenotype-based screening using knowledge graph

A novel approach for target deconvolution from phenotype-based screening using knowledge graph

Abstract Deconvoluting drug targets is crucial in modern drug development, yet both traditional and artificial intelligence (AI)-driven methods face challenges in terms of completeness, accuracy, and efficiency. Identifying drug targets, especially within complex systems such as the p53 pathway, rem...

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Bibliographic Details
Main Authors: Xiaohong Wang, Meifang Zhang, Jianliang Xu, Xin Li, Jing Xiong, Haowei Cao, Fangkun Dou, Xue Zhai, Hua Sun
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Drug target deconvolution
Knowledge graph
Protein-protein interaction
Molecular docking
P53 pathway activator
Online Access:https://doi.org/10.1038/s41598-025-86166-w
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