Sweet Taste Receptor Signaling Network: Possible Implication for Cognitive Functioning
Sweet taste receptors are transmembrane protein network specialized in the transmission of information from special “sweet” molecules into the intracellular domain. These receptors can sense the taste of a range of molecules and transmit the information downstream to several acceptors, modulate cell...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2015/606479 |
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| author | Menizibeya O. Welcome Nikos E. Mastorakis Vladimir A. Pereverzev |
| author_facet | Menizibeya O. Welcome Nikos E. Mastorakis Vladimir A. Pereverzev |
| author_sort | Menizibeya O. Welcome |
| collection | DOAJ |
| description | Sweet taste receptors are transmembrane protein network specialized in the transmission of information from special “sweet” molecules into the intracellular domain. These receptors can sense the taste of a range of molecules and transmit the information downstream to several acceptors, modulate cell specific functions and metabolism, and mediate cell-to-cell coupling through paracrine mechanism. Recent reports indicate that sweet taste receptors are widely distributed in the body and serves specific function relative to their localization. Due to their pleiotropic signaling properties and multisubstrate ligand affinity, sweet taste receptors are able to cooperatively bind multiple substances and mediate signaling by other receptors. Based on increasing evidence about the role of these receptors in the initiation and control of absorption and metabolism, and the pivotal role of metabolic (glucose) regulation in the central nervous system functioning, we propose a possible implication of sweet taste receptor signaling in modulating cognitive functioning. |
| format | Article |
| id | doaj-art-00faa1b4aeb84f86a908d60dcf7f3dc7 |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-00faa1b4aeb84f86a908d60dcf7f3dc72025-02-03T01:09:30ZengWileyNeurology Research International2090-18522090-18602015-01-01201510.1155/2015/606479606479Sweet Taste Receptor Signaling Network: Possible Implication for Cognitive FunctioningMenizibeya O. Welcome0Nikos E. Mastorakis1Vladimir A. Pereverzev2World Scientific and Engineering Academy and Society, Ag. Ioannou Theologou 17-23, Zografou, 15773 Athens, GreeceWorld Scientific and Engineering Academy and Society, Ag. Ioannou Theologou 17-23, Zografou, 15773 Athens, GreeceDepartment of Normal Physiology, Belarusian State Medical University, Dzerzhinsky Avenue 83, 220116 Minsk, BelarusSweet taste receptors are transmembrane protein network specialized in the transmission of information from special “sweet” molecules into the intracellular domain. These receptors can sense the taste of a range of molecules and transmit the information downstream to several acceptors, modulate cell specific functions and metabolism, and mediate cell-to-cell coupling through paracrine mechanism. Recent reports indicate that sweet taste receptors are widely distributed in the body and serves specific function relative to their localization. Due to their pleiotropic signaling properties and multisubstrate ligand affinity, sweet taste receptors are able to cooperatively bind multiple substances and mediate signaling by other receptors. Based on increasing evidence about the role of these receptors in the initiation and control of absorption and metabolism, and the pivotal role of metabolic (glucose) regulation in the central nervous system functioning, we propose a possible implication of sweet taste receptor signaling in modulating cognitive functioning.http://dx.doi.org/10.1155/2015/606479 |
| spellingShingle | Menizibeya O. Welcome Nikos E. Mastorakis Vladimir A. Pereverzev Sweet Taste Receptor Signaling Network: Possible Implication for Cognitive Functioning Neurology Research International |
| title | Sweet Taste Receptor Signaling Network: Possible Implication for Cognitive Functioning |
| title_full | Sweet Taste Receptor Signaling Network: Possible Implication for Cognitive Functioning |
| title_fullStr | Sweet Taste Receptor Signaling Network: Possible Implication for Cognitive Functioning |
| title_full_unstemmed | Sweet Taste Receptor Signaling Network: Possible Implication for Cognitive Functioning |
| title_short | Sweet Taste Receptor Signaling Network: Possible Implication for Cognitive Functioning |
| title_sort | sweet taste receptor signaling network possible implication for cognitive functioning |
| url | http://dx.doi.org/10.1155/2015/606479 |
| work_keys_str_mv | AT menizibeyaowelcome sweettastereceptorsignalingnetworkpossibleimplicationforcognitivefunctioning AT nikosemastorakis sweettastereceptorsignalingnetworkpossibleimplicationforcognitivefunctioning AT vladimirapereverzev sweettastereceptorsignalingnetworkpossibleimplicationforcognitivefunctioning |