Topical Application of Liriope platyphylla Extract Attenuates Dry Eye Syndrome Induced by Particulate Matter
Particulate matter (PM) is a type of air pollutant that poses a risk to human health. In the ocular system, PM causes or aggravates dry eye syndrome (DES) by damaging the corneal and conjunctival epithelia. Liriope platyphylla has been used traditionally as an expectorant, antitussive agent, and ton...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2019/1429548 |
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| author | Su Jeong Song Soo-Wang Hyun Tae Gu Lee Bongkyun Park Kyuhyung Jo Ik Soo Lee Chan-Sik Kim |
| author_facet | Su Jeong Song Soo-Wang Hyun Tae Gu Lee Bongkyun Park Kyuhyung Jo Ik Soo Lee Chan-Sik Kim |
| author_sort | Su Jeong Song |
| collection | DOAJ |
| description | Particulate matter (PM) is a type of air pollutant that poses a risk to human health. In the ocular system, PM causes or aggravates dry eye syndrome (DES) by damaging the corneal and conjunctival epithelia. Liriope platyphylla has been used traditionally as an expectorant, antitussive agent, and tonic in Korea. However, the effects of Liriope platyphylla extract (LPE) on PM-induced ocular damage have not been elucidated. In this study, we evaluated the in vivo protective effect of LPE against PM-induced DES in rats. Topical administration of LPE attenuated the PM-induced decrease in tear volume and reduced corneal epithelial irregularity and damage. LPE also protected against PM-induced disruption of the corneal mucin-4 layer and reduction in the conjunctival goblet cell density. These findings suggest that LPE has protective effects against PM-induced DES. |
| format | Article |
| id | doaj-art-00ec85b0fe344a98a147f937d9416919 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-00ec85b0fe344a98a147f937d94169192025-02-03T01:01:45ZengWileyJournal of Ophthalmology2090-004X2090-00582019-01-01201910.1155/2019/14295481429548Topical Application of Liriope platyphylla Extract Attenuates Dry Eye Syndrome Induced by Particulate MatterSu Jeong Song0Soo-Wang Hyun1Tae Gu Lee2Bongkyun Park3Kyuhyung Jo4Ik Soo Lee5Chan-Sik Kim6Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of KoreaHerbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of KoreaClinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of KoreaClinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of KoreaNon-clinical Research Collaboration Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of KoreaNon-clinical Research Collaboration Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of KoreaClinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of KoreaParticulate matter (PM) is a type of air pollutant that poses a risk to human health. In the ocular system, PM causes or aggravates dry eye syndrome (DES) by damaging the corneal and conjunctival epithelia. Liriope platyphylla has been used traditionally as an expectorant, antitussive agent, and tonic in Korea. However, the effects of Liriope platyphylla extract (LPE) on PM-induced ocular damage have not been elucidated. In this study, we evaluated the in vivo protective effect of LPE against PM-induced DES in rats. Topical administration of LPE attenuated the PM-induced decrease in tear volume and reduced corneal epithelial irregularity and damage. LPE also protected against PM-induced disruption of the corneal mucin-4 layer and reduction in the conjunctival goblet cell density. These findings suggest that LPE has protective effects against PM-induced DES.http://dx.doi.org/10.1155/2019/1429548 |
| spellingShingle | Su Jeong Song Soo-Wang Hyun Tae Gu Lee Bongkyun Park Kyuhyung Jo Ik Soo Lee Chan-Sik Kim Topical Application of Liriope platyphylla Extract Attenuates Dry Eye Syndrome Induced by Particulate Matter Journal of Ophthalmology |
| title | Topical Application of Liriope platyphylla Extract Attenuates Dry Eye Syndrome Induced by Particulate Matter |
| title_full | Topical Application of Liriope platyphylla Extract Attenuates Dry Eye Syndrome Induced by Particulate Matter |
| title_fullStr | Topical Application of Liriope platyphylla Extract Attenuates Dry Eye Syndrome Induced by Particulate Matter |
| title_full_unstemmed | Topical Application of Liriope platyphylla Extract Attenuates Dry Eye Syndrome Induced by Particulate Matter |
| title_short | Topical Application of Liriope platyphylla Extract Attenuates Dry Eye Syndrome Induced by Particulate Matter |
| title_sort | topical application of liriope platyphylla extract attenuates dry eye syndrome induced by particulate matter |
| url | http://dx.doi.org/10.1155/2019/1429548 |
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