Microenvironment-Centred Dynamics in Aggressive B-Cell Lymphomas
Aggressive B-cell lymphomas share high proliferative and invasive attitudes and dismal prognosis despite heterogeneous biological features. In the interchained sequence of events leading to cancer progression, neoplastic clone-intrinsic molecular events play a major role. Nevertheless, microenvironm...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2012/138079 |
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| _version_ | 1832560780482969600 |
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| author | Matilde Cacciatore Carla Guarnotta Marco Calvaruso Sabina Sangaletti Ada Maria Florena Vito Franco Mario Paolo Colombo Claudio Tripodo |
| author_facet | Matilde Cacciatore Carla Guarnotta Marco Calvaruso Sabina Sangaletti Ada Maria Florena Vito Franco Mario Paolo Colombo Claudio Tripodo |
| author_sort | Matilde Cacciatore |
| collection | DOAJ |
| description | Aggressive B-cell lymphomas share high proliferative and invasive attitudes and dismal prognosis despite heterogeneous biological features. In the interchained sequence of events leading to cancer progression, neoplastic clone-intrinsic molecular events play a major role. Nevertheless, microenvironment-related cues have progressively come into focus as true determinants for this process. The cancer-associated microenvironment is a complex network of nonneoplastic immune and stromal cells embedded in extracellular components, giving rise to a multifarious crosstalk with neoplastic cells towards the induction of a supportive milieu. The immunological and stromal microenvironments have been classically regarded as essential partners of indolent lymphomas, while considered mainly negligible in the setting of aggressive B-cell lymphomas that, by their nature, are less reliant on external stimuli. By this paper we try to delineate the cardinal microenvironment-centred dynamics exerting an influence over lymphoid clone progression in aggressive B-cell lymphomas. |
| format | Article |
| id | doaj-art-00ea5bbec93747b2acab63d8a7e3be07 |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-00ea5bbec93747b2acab63d8a7e3be072025-02-03T01:26:36ZengWileyAdvances in Hematology1687-91041687-91122012-01-01201210.1155/2012/138079138079Microenvironment-Centred Dynamics in Aggressive B-Cell LymphomasMatilde Cacciatore0Carla Guarnotta1Marco Calvaruso2Sabina Sangaletti3Ada Maria Florena4Vito Franco5Mario Paolo Colombo6Claudio Tripodo7Dipartimento di Scienze per la Promozione della Salute, Sezione di Anatomia Patologica, Università degli Studi di Palermo, 90127 Palermo, ItalyDipartimento di Scienze per la Promozione della Salute, Sezione di Anatomia Patologica, Università degli Studi di Palermo, 90127 Palermo, ItalyDipartimento di Scienze per la Promozione della Salute, Sezione di Anatomia Patologica, Università degli Studi di Palermo, 90127 Palermo, ItalyDipartimento di Oncologia Sperimentale, Unità di Immunologia Molecolare, IRCCS Fondazione Istituto Nazionale Tumori, 20133 Milano, ItalyDipartimento di Scienze per la Promozione della Salute, Sezione di Anatomia Patologica, Università degli Studi di Palermo, 90127 Palermo, ItalyDipartimento di Scienze per la Promozione della Salute, Sezione di Anatomia Patologica, Università degli Studi di Palermo, 90127 Palermo, ItalyDipartimento di Oncologia Sperimentale, Unità di Immunologia Molecolare, IRCCS Fondazione Istituto Nazionale Tumori, 20133 Milano, ItalyDipartimento di Scienze per la Promozione della Salute, Sezione di Anatomia Patologica, Università degli Studi di Palermo, 90127 Palermo, ItalyAggressive B-cell lymphomas share high proliferative and invasive attitudes and dismal prognosis despite heterogeneous biological features. In the interchained sequence of events leading to cancer progression, neoplastic clone-intrinsic molecular events play a major role. Nevertheless, microenvironment-related cues have progressively come into focus as true determinants for this process. The cancer-associated microenvironment is a complex network of nonneoplastic immune and stromal cells embedded in extracellular components, giving rise to a multifarious crosstalk with neoplastic cells towards the induction of a supportive milieu. The immunological and stromal microenvironments have been classically regarded as essential partners of indolent lymphomas, while considered mainly negligible in the setting of aggressive B-cell lymphomas that, by their nature, are less reliant on external stimuli. By this paper we try to delineate the cardinal microenvironment-centred dynamics exerting an influence over lymphoid clone progression in aggressive B-cell lymphomas.http://dx.doi.org/10.1155/2012/138079 |
| spellingShingle | Matilde Cacciatore Carla Guarnotta Marco Calvaruso Sabina Sangaletti Ada Maria Florena Vito Franco Mario Paolo Colombo Claudio Tripodo Microenvironment-Centred Dynamics in Aggressive B-Cell Lymphomas Advances in Hematology |
| title | Microenvironment-Centred Dynamics in Aggressive B-Cell Lymphomas |
| title_full | Microenvironment-Centred Dynamics in Aggressive B-Cell Lymphomas |
| title_fullStr | Microenvironment-Centred Dynamics in Aggressive B-Cell Lymphomas |
| title_full_unstemmed | Microenvironment-Centred Dynamics in Aggressive B-Cell Lymphomas |
| title_short | Microenvironment-Centred Dynamics in Aggressive B-Cell Lymphomas |
| title_sort | microenvironment centred dynamics in aggressive b cell lymphomas |
| url | http://dx.doi.org/10.1155/2012/138079 |
| work_keys_str_mv | AT matildecacciatore microenvironmentcentreddynamicsinaggressivebcelllymphomas AT carlaguarnotta microenvironmentcentreddynamicsinaggressivebcelllymphomas AT marcocalvaruso microenvironmentcentreddynamicsinaggressivebcelllymphomas AT sabinasangaletti microenvironmentcentreddynamicsinaggressivebcelllymphomas AT adamariaflorena microenvironmentcentreddynamicsinaggressivebcelllymphomas AT vitofranco microenvironmentcentreddynamicsinaggressivebcelllymphomas AT mariopaolocolombo microenvironmentcentreddynamicsinaggressivebcelllymphomas AT claudiotripodo microenvironmentcentreddynamicsinaggressivebcelllymphomas |