The interaction between gut microbiome and nutrients on development of human disease through epigenetic mechanisms
Early environmental exposure is recognized as a key factor for long-term health based on the Developmental Origins of Health and Disease hypothesis. It considers that early-life nutrition is now being recognized as a major contributor that may permanently program change of organ structure and functi...
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| Format: | Article |
| Language: | English |
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BioMed Central
2019-09-01
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| Series: | Genomics & Informatics |
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| Online Access: | http://genominfo.org/upload/pdf/gi-2019-17-3-e24.pdf |
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| _version_ | 1832569976911822848 |
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| author | Ho-Sun Lee |
| author_facet | Ho-Sun Lee |
| author_sort | Ho-Sun Lee |
| collection | DOAJ |
| description | Early environmental exposure is recognized as a key factor for long-term health based on the Developmental Origins of Health and Disease hypothesis. It considers that early-life nutrition is now being recognized as a major contributor that may permanently program change of organ structure and function toward the development of diseases, in which epigenetic mechanisms are involved. Recent researches indicate early-life environmental factors modulate the microbiome development and the microbiome might be mediate diet-epigenetic interaction. This review aims to define which nutrients involve microbiome development during the critical window of susceptibility to disease, and how microbiome modulation regulates epigenetic changes and influences human health and future prevention strategies. |
| format | Article |
| id | doaj-art-00e967d8d09045498830f00215bc9f56 |
| institution | Kabale University |
| issn | 2234-0742 |
| language | English |
| publishDate | 2019-09-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-00e967d8d09045498830f00215bc9f562025-02-02T18:21:55ZengBioMed CentralGenomics & Informatics2234-07422019-09-0117310.5808/GI.2019.17.3.e24571The interaction between gut microbiome and nutrients on development of human disease through epigenetic mechanismsHo-Sun LeeEarly environmental exposure is recognized as a key factor for long-term health based on the Developmental Origins of Health and Disease hypothesis. It considers that early-life nutrition is now being recognized as a major contributor that may permanently program change of organ structure and function toward the development of diseases, in which epigenetic mechanisms are involved. Recent researches indicate early-life environmental factors modulate the microbiome development and the microbiome might be mediate diet-epigenetic interaction. This review aims to define which nutrients involve microbiome development during the critical window of susceptibility to disease, and how microbiome modulation regulates epigenetic changes and influences human health and future prevention strategies.http://genominfo.org/upload/pdf/gi-2019-17-3-e24.pdfdisease developmentfetal reprogramminggut microbiomenutrition |
| spellingShingle | Ho-Sun Lee The interaction between gut microbiome and nutrients on development of human disease through epigenetic mechanisms Genomics & Informatics disease development fetal reprogramming gut microbiome nutrition |
| title | The interaction between gut microbiome and nutrients on development of human disease through epigenetic mechanisms |
| title_full | The interaction between gut microbiome and nutrients on development of human disease through epigenetic mechanisms |
| title_fullStr | The interaction between gut microbiome and nutrients on development of human disease through epigenetic mechanisms |
| title_full_unstemmed | The interaction between gut microbiome and nutrients on development of human disease through epigenetic mechanisms |
| title_short | The interaction between gut microbiome and nutrients on development of human disease through epigenetic mechanisms |
| title_sort | interaction between gut microbiome and nutrients on development of human disease through epigenetic mechanisms |
| topic | disease development fetal reprogramming gut microbiome nutrition |
| url | http://genominfo.org/upload/pdf/gi-2019-17-3-e24.pdf |
| work_keys_str_mv | AT hosunlee theinteractionbetweengutmicrobiomeandnutrientsondevelopmentofhumandiseasethroughepigeneticmechanisms AT hosunlee interactionbetweengutmicrobiomeandnutrientsondevelopmentofhumandiseasethroughepigeneticmechanisms |