Prevalence, Molecular Epidemiology, and Clinical Characteristics of Human Bocavirus Among Patients with Acute Gastroenteritis in Northern Brazil During 2017–2022
Acute gastroenteritis (AG) is a major illness in early childhood. Recent studies suggest a potential association between human bocavirus (HBoV) and AG. HBoV, a non-enveloped virus with a single-strand DNA genome, belongs to the Parvoviridae family. This study aimed to describe the frequency of HBoV...
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2025-01-01
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| author | Yasmim Gabrielly Souza Sousa Carolina Alcântara Maneschy Carolina Costa Monteiro João Victor Souza Rodrigues Patrícia Santos Lobo Dielle Monteiro Teixeira Jones Anderson Monteiro Siqueira Kenny Costa Pinheiro Hugo Reis Resque Luciana Damascena Silva Sylvia Fátima dos Santos Guerra Luana Silva Soares |
| author_facet | Yasmim Gabrielly Souza Sousa Carolina Alcântara Maneschy Carolina Costa Monteiro João Victor Souza Rodrigues Patrícia Santos Lobo Dielle Monteiro Teixeira Jones Anderson Monteiro Siqueira Kenny Costa Pinheiro Hugo Reis Resque Luciana Damascena Silva Sylvia Fátima dos Santos Guerra Luana Silva Soares |
| author_sort | Yasmim Gabrielly Souza Sousa |
| collection | DOAJ |
| description | Acute gastroenteritis (AG) is a major illness in early childhood. Recent studies suggest a potential association between human bocavirus (HBoV) and AG. HBoV, a non-enveloped virus with a single-strand DNA genome, belongs to the Parvoviridae family. This study aimed to describe the frequency of HBoV in Northern Brazil using samples from patients with AG collected between 2017 and 2022. Fecal samples obtained from the viral gastroenteritis surveillance network at the Evandro Chagas Institute (IEC) were analyzed. Fecal suspensions (20%) were prepared, and the viral genome was extracted. PCR and nested-PCR were employed to detect HBoV, followed by nucleotide sequencing to identify viral types. Out of 692 samples, HBoV positivity was detected in 9.2% of cases (64/692). Genotypes HBoV-1, HBoV-2, HBoV-3, and HBoV-4 were found in 42.5% (17/40), 22.5% (9/40), 32.5% (13/40), and 2.5% (1/40) of the specimens, respectively. Co-infections with HBoV and other enteric viruses occurred in 48.3% (31/64) of cases, with RVA being the most frequent (31.2%, 20/64). The study results underscore the importance of continuous monitoring and further research to better understand the seasonality, coinfection patterns, and genetic variability of HBoV. |
| format | Article |
| id | doaj-art-00dd9fc2c1c847c78f110a5b56447cbf |
| institution | Kabale University |
| issn | 1999-4915 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj-art-00dd9fc2c1c847c78f110a5b56447cbf2025-01-24T13:52:30ZengMDPI AGViruses1999-49152025-01-011717910.3390/v17010079Prevalence, Molecular Epidemiology, and Clinical Characteristics of Human Bocavirus Among Patients with Acute Gastroenteritis in Northern Brazil During 2017–2022Yasmim Gabrielly Souza Sousa0Carolina Alcântara Maneschy1Carolina Costa Monteiro2João Victor Souza Rodrigues3Patrícia Santos Lobo4Dielle Monteiro Teixeira5Jones Anderson Monteiro Siqueira6Kenny Costa Pinheiro7Hugo Reis Resque8Luciana Damascena Silva9Sylvia Fátima dos Santos Guerra10Luana Silva Soares11Postgraduate Program in Virology, Teaching and Scientific Information Section, Evandro Chagas Institute, Secretariat of Health Surveillance and Environment, Brazilian Ministry of Health, Ananindeua 67.030-000, Pará, BrazilPostgraduate Program in Virology, Teaching and Scientific Information Section, Evandro Chagas Institute, Secretariat of Health Surveillance and Environment, Brazilian Ministry of Health, Ananindeua 67.030-000, Pará, BrazilLaboratory of Gastroenteric Virus, Virology Section, Evandro Chagas Institute, Secretariat of Health Surveillance and Environment, Brazilian Ministry of Health, Ananindeua 67.030-000, Pará, BrazilLaboratory of Gastroenteric Virus, Virology Section, Evandro Chagas Institute, Secretariat of Health Surveillance and Environment, Brazilian Ministry of Health, Ananindeua 67.030-000, Pará, BrazilLaboratory of Gastroenteric Virus, Virology Section, Evandro Chagas Institute, Secretariat of Health Surveillance and Environment, Brazilian Ministry of Health, Ananindeua 67.030-000, Pará, BrazilLaboratory of Gastroenteric Virus, Virology Section, Evandro Chagas Institute, Secretariat of Health Surveillance and Environment, Brazilian Ministry of Health, Ananindeua 67.030-000, Pará, BrazilLaboratory of Gastroenteric Virus, Virology Section, Evandro Chagas Institute, Secretariat of Health Surveillance and Environment, Brazilian Ministry of Health, Ananindeua 67.030-000, Pará, BrazilLaboratory of Gastroenteric Virus, Virology Section, Evandro Chagas Institute, Secretariat of Health Surveillance and Environment, Brazilian Ministry of Health, Ananindeua 67.030-000, Pará, BrazilLaboratory of Gastroenteric Virus, Virology Section, Evandro Chagas Institute, Secretariat of Health Surveillance and Environment, Brazilian Ministry of Health, Ananindeua 67.030-000, Pará, BrazilLaboratory of Gastroenteric Virus, Virology Section, Evandro Chagas Institute, Secretariat of Health Surveillance and Environment, Brazilian Ministry of Health, Ananindeua 67.030-000, Pará, BrazilLaboratory of Gastroenteric Virus, Virology Section, Evandro Chagas Institute, Secretariat of Health Surveillance and Environment, Brazilian Ministry of Health, Ananindeua 67.030-000, Pará, BrazilLaboratory of Gastroenteric Virus, Virology Section, Evandro Chagas Institute, Secretariat of Health Surveillance and Environment, Brazilian Ministry of Health, Ananindeua 67.030-000, Pará, BrazilAcute gastroenteritis (AG) is a major illness in early childhood. Recent studies suggest a potential association between human bocavirus (HBoV) and AG. HBoV, a non-enveloped virus with a single-strand DNA genome, belongs to the Parvoviridae family. This study aimed to describe the frequency of HBoV in Northern Brazil using samples from patients with AG collected between 2017 and 2022. Fecal samples obtained from the viral gastroenteritis surveillance network at the Evandro Chagas Institute (IEC) were analyzed. Fecal suspensions (20%) were prepared, and the viral genome was extracted. PCR and nested-PCR were employed to detect HBoV, followed by nucleotide sequencing to identify viral types. Out of 692 samples, HBoV positivity was detected in 9.2% of cases (64/692). Genotypes HBoV-1, HBoV-2, HBoV-3, and HBoV-4 were found in 42.5% (17/40), 22.5% (9/40), 32.5% (13/40), and 2.5% (1/40) of the specimens, respectively. Co-infections with HBoV and other enteric viruses occurred in 48.3% (31/64) of cases, with RVA being the most frequent (31.2%, 20/64). The study results underscore the importance of continuous monitoring and further research to better understand the seasonality, coinfection patterns, and genetic variability of HBoV.https://www.mdpi.com/1999-4915/17/1/79human bocavirusacute gastroenteritisviral coinfectiongenotypes |
| spellingShingle | Yasmim Gabrielly Souza Sousa Carolina Alcântara Maneschy Carolina Costa Monteiro João Victor Souza Rodrigues Patrícia Santos Lobo Dielle Monteiro Teixeira Jones Anderson Monteiro Siqueira Kenny Costa Pinheiro Hugo Reis Resque Luciana Damascena Silva Sylvia Fátima dos Santos Guerra Luana Silva Soares Prevalence, Molecular Epidemiology, and Clinical Characteristics of Human Bocavirus Among Patients with Acute Gastroenteritis in Northern Brazil During 2017–2022 Viruses human bocavirus acute gastroenteritis viral coinfection genotypes |
| title | Prevalence, Molecular Epidemiology, and Clinical Characteristics of Human Bocavirus Among Patients with Acute Gastroenteritis in Northern Brazil During 2017–2022 |
| title_full | Prevalence, Molecular Epidemiology, and Clinical Characteristics of Human Bocavirus Among Patients with Acute Gastroenteritis in Northern Brazil During 2017–2022 |
| title_fullStr | Prevalence, Molecular Epidemiology, and Clinical Characteristics of Human Bocavirus Among Patients with Acute Gastroenteritis in Northern Brazil During 2017–2022 |
| title_full_unstemmed | Prevalence, Molecular Epidemiology, and Clinical Characteristics of Human Bocavirus Among Patients with Acute Gastroenteritis in Northern Brazil During 2017–2022 |
| title_short | Prevalence, Molecular Epidemiology, and Clinical Characteristics of Human Bocavirus Among Patients with Acute Gastroenteritis in Northern Brazil During 2017–2022 |
| title_sort | prevalence molecular epidemiology and clinical characteristics of human bocavirus among patients with acute gastroenteritis in northern brazil during 2017 2022 |
| topic | human bocavirus acute gastroenteritis viral coinfection genotypes |
| url | https://www.mdpi.com/1999-4915/17/1/79 |
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