Clinical Characteristics of Aldosterone- and Cortisol-Coproducing Adrenal Adenoma in Primary Aldosteronism
Aldosterone- and cortisol-coproducing adrenal adenoma (A/CPA) cases have been observed in patients with primary aldosteronism (PA). This study investigated the incidence, clinical characteristics, and molecular biological features of patients with A/CPAs. We retrospectively identified 22 A/CPA patie...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/4920841 |
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| author | Lu Tang Xintao Li Baojun Wang Xin Ma Hongzhao Li Yu Gao Liangyou Gu Wenyuan Nie Xu Zhang |
| author_facet | Lu Tang Xintao Li Baojun Wang Xin Ma Hongzhao Li Yu Gao Liangyou Gu Wenyuan Nie Xu Zhang |
| author_sort | Lu Tang |
| collection | DOAJ |
| description | Aldosterone- and cortisol-coproducing adrenal adenoma (A/CPA) cases have been observed in patients with primary aldosteronism (PA). This study investigated the incidence, clinical characteristics, and molecular biological features of patients with A/CPAs. We retrospectively identified 22 A/CPA patients from 555 PA patients who visited the Chinese People’s Liberation Army General Hospital between 2004 and 2015. Analysis of clinical parameters revealed that patients with A/CPAs had larger tumors than those with pure APAs (P<0.05). Moreover, they had higher proportions of cardiovascular complications, glucose intolerance/diabetes, and osteopenia/osteoporosis compared to the pure APA patients (P<0.001). In the molecular biological findings, quantitative real-time PCR analysis revealed similar CYP11B1 and CYP17A1 mRNA expressions in resected A/CPA specimens and in pure APA specimens. Western blot and immunochemical analyses showed CYP11B1, CYP11B2, and CYP17A1 expressions in both A/CPAs and pure APAs. Seventeen cases with KCNJ5 mutations were detected among the 22 A/CPA DNA samples, but no PRKACA or other causative mutations were observed. Each patient improved following adrenalectomy. In conclusion, A/CPAs were not rare among PA patients. These patients associated with high incidences of cardiovascular events and metabolic disorders. Screening for excess cortisol secretion is necessary for PA patients. |
| format | Article |
| id | doaj-art-00d71e48d0564bf699e215430923ed76 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-00d71e48d0564bf699e215430923ed762025-02-03T00:59:04ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/49208414920841Clinical Characteristics of Aldosterone- and Cortisol-Coproducing Adrenal Adenoma in Primary AldosteronismLu Tang0Xintao Li1Baojun Wang2Xin Ma3Hongzhao Li4Yu Gao5Liangyou Gu6Wenyuan Nie7Xu Zhang8State Key Laboratory of Kidney Disease, Department of Urology, Chinese PLA Medical Academy, Chinese People’s Liberation Army General Hospital, Beijing, ChinaDepartment of Urology, Air Force General Hospital, Beijing, ChinaState Key Laboratory of Kidney Disease, Department of Urology, Chinese PLA Medical Academy, Chinese People’s Liberation Army General Hospital, Beijing, ChinaState Key Laboratory of Kidney Disease, Department of Urology, Chinese PLA Medical Academy, Chinese People’s Liberation Army General Hospital, Beijing, ChinaState Key Laboratory of Kidney Disease, Department of Urology, Chinese PLA Medical Academy, Chinese People’s Liberation Army General Hospital, Beijing, ChinaState Key Laboratory of Kidney Disease, Department of Urology, Chinese PLA Medical Academy, Chinese People’s Liberation Army General Hospital, Beijing, ChinaState Key Laboratory of Kidney Disease, Department of Urology, Chinese PLA Medical Academy, Chinese People’s Liberation Army General Hospital, Beijing, ChinaState Key Laboratory of Kidney Disease, Department of Urology, Chinese PLA Medical Academy, Chinese People’s Liberation Army General Hospital, Beijing, ChinaState Key Laboratory of Kidney Disease, Department of Urology, Chinese PLA Medical Academy, Chinese People’s Liberation Army General Hospital, Beijing, ChinaAldosterone- and cortisol-coproducing adrenal adenoma (A/CPA) cases have been observed in patients with primary aldosteronism (PA). This study investigated the incidence, clinical characteristics, and molecular biological features of patients with A/CPAs. We retrospectively identified 22 A/CPA patients from 555 PA patients who visited the Chinese People’s Liberation Army General Hospital between 2004 and 2015. Analysis of clinical parameters revealed that patients with A/CPAs had larger tumors than those with pure APAs (P<0.05). Moreover, they had higher proportions of cardiovascular complications, glucose intolerance/diabetes, and osteopenia/osteoporosis compared to the pure APA patients (P<0.001). In the molecular biological findings, quantitative real-time PCR analysis revealed similar CYP11B1 and CYP17A1 mRNA expressions in resected A/CPA specimens and in pure APA specimens. Western blot and immunochemical analyses showed CYP11B1, CYP11B2, and CYP17A1 expressions in both A/CPAs and pure APAs. Seventeen cases with KCNJ5 mutations were detected among the 22 A/CPA DNA samples, but no PRKACA or other causative mutations were observed. Each patient improved following adrenalectomy. In conclusion, A/CPAs were not rare among PA patients. These patients associated with high incidences of cardiovascular events and metabolic disorders. Screening for excess cortisol secretion is necessary for PA patients.http://dx.doi.org/10.1155/2018/4920841 |
| spellingShingle | Lu Tang Xintao Li Baojun Wang Xin Ma Hongzhao Li Yu Gao Liangyou Gu Wenyuan Nie Xu Zhang Clinical Characteristics of Aldosterone- and Cortisol-Coproducing Adrenal Adenoma in Primary Aldosteronism International Journal of Endocrinology |
| title | Clinical Characteristics of Aldosterone- and Cortisol-Coproducing Adrenal Adenoma in Primary Aldosteronism |
| title_full | Clinical Characteristics of Aldosterone- and Cortisol-Coproducing Adrenal Adenoma in Primary Aldosteronism |
| title_fullStr | Clinical Characteristics of Aldosterone- and Cortisol-Coproducing Adrenal Adenoma in Primary Aldosteronism |
| title_full_unstemmed | Clinical Characteristics of Aldosterone- and Cortisol-Coproducing Adrenal Adenoma in Primary Aldosteronism |
| title_short | Clinical Characteristics of Aldosterone- and Cortisol-Coproducing Adrenal Adenoma in Primary Aldosteronism |
| title_sort | clinical characteristics of aldosterone and cortisol coproducing adrenal adenoma in primary aldosteronism |
| url | http://dx.doi.org/10.1155/2018/4920841 |
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