Neuroendocrine Alterations in Obese Patients with Sleep Apnea Syndrome
Obstructive sleep apnea syndrome (OSAS) is a serious, prevalent condition that has significant morbidity and mortality when untreated. It is strongly associated with obesity and is characterized by changes in the serum levels or secretory patterns of several hormones. Obese patients with OSAS show a...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2010/474518 |
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| author | Fabio Lanfranco Giovanna Motta Marco Alessandro Minetto Matteo Baldi Marcella Balbo Ezio Ghigo Emanuela Arvat Mauro Maccario |
| author_facet | Fabio Lanfranco Giovanna Motta Marco Alessandro Minetto Matteo Baldi Marcella Balbo Ezio Ghigo Emanuela Arvat Mauro Maccario |
| author_sort | Fabio Lanfranco |
| collection | DOAJ |
| description | Obstructive sleep apnea syndrome (OSAS) is a serious, prevalent condition that has significant morbidity and mortality when untreated. It is strongly associated with obesity and is characterized by changes in the serum levels or secretory patterns of several hormones. Obese patients with OSAS show a reduction of both spontaneous and stimulated growth hormone (GH) secretion coupled to reduced insulin-like growth factor-I (IGF-I) concentrations and impaired peripheral sensitivity to GH. Hypoxemia and chronic sleep fragmentation could affect the sleep-entrained prolactin (PRL) rhythm. A disrupted Hypothalamus-Pituitary-Adrenal (HPA) axis activity has been described in OSAS. Some derangement in Thyroid-Stimulating Hormone (TSH) secretion has been demonstrated by some authors, whereas a normal thyroid activity has been described by others. Changes of gonadal axis are common in patients with OSAS, who frequently show a hypogonadotropic hypogonadism. Altogether, hormonal abnormalities may be considered as adaptive changes which indicate how a local upper airway dysfunction induces systemic consequences. The understanding of the complex interactions between hormones and OSAS may allow a multi-disciplinary approach to obese patients with this disturbance and lead to an effective management that improves quality of life and prevents associated morbidity or death. |
| format | Article |
| id | doaj-art-00d39c24c9b14881b7d214a45a00cac9 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-00d39c24c9b14881b7d214a45a00cac92025-02-03T06:00:53ZengWileyInternational Journal of Endocrinology1687-83371687-83452010-01-01201010.1155/2010/474518474518Neuroendocrine Alterations in Obese Patients with Sleep Apnea SyndromeFabio Lanfranco0Giovanna Motta1Marco Alessandro Minetto2Matteo Baldi3Marcella Balbo4Ezio Ghigo5Emanuela Arvat6Mauro Maccario7Division of Endocrinology, Diabetology and Metabolism, Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Torino, ItalyDivision of Endocrinology, Diabetology and Metabolism, Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Torino, ItalyDivision of Endocrinology, Diabetology and Metabolism, Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Torino, ItalyDivision of Endocrinology, Diabetology and Metabolism, Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Torino, ItalyDivision of Endocrinology, Diabetology and Metabolism, Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Torino, ItalyDivision of Endocrinology, Diabetology and Metabolism, Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Torino, ItalyDivision of Endocrinology, Diabetology and Metabolism, Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Torino, ItalyDivision of Endocrinology, Diabetology and Metabolism, Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126 Torino, ItalyObstructive sleep apnea syndrome (OSAS) is a serious, prevalent condition that has significant morbidity and mortality when untreated. It is strongly associated with obesity and is characterized by changes in the serum levels or secretory patterns of several hormones. Obese patients with OSAS show a reduction of both spontaneous and stimulated growth hormone (GH) secretion coupled to reduced insulin-like growth factor-I (IGF-I) concentrations and impaired peripheral sensitivity to GH. Hypoxemia and chronic sleep fragmentation could affect the sleep-entrained prolactin (PRL) rhythm. A disrupted Hypothalamus-Pituitary-Adrenal (HPA) axis activity has been described in OSAS. Some derangement in Thyroid-Stimulating Hormone (TSH) secretion has been demonstrated by some authors, whereas a normal thyroid activity has been described by others. Changes of gonadal axis are common in patients with OSAS, who frequently show a hypogonadotropic hypogonadism. Altogether, hormonal abnormalities may be considered as adaptive changes which indicate how a local upper airway dysfunction induces systemic consequences. The understanding of the complex interactions between hormones and OSAS may allow a multi-disciplinary approach to obese patients with this disturbance and lead to an effective management that improves quality of life and prevents associated morbidity or death.http://dx.doi.org/10.1155/2010/474518 |
| spellingShingle | Fabio Lanfranco Giovanna Motta Marco Alessandro Minetto Matteo Baldi Marcella Balbo Ezio Ghigo Emanuela Arvat Mauro Maccario Neuroendocrine Alterations in Obese Patients with Sleep Apnea Syndrome International Journal of Endocrinology |
| title | Neuroendocrine Alterations in Obese Patients with Sleep Apnea Syndrome |
| title_full | Neuroendocrine Alterations in Obese Patients with Sleep Apnea Syndrome |
| title_fullStr | Neuroendocrine Alterations in Obese Patients with Sleep Apnea Syndrome |
| title_full_unstemmed | Neuroendocrine Alterations in Obese Patients with Sleep Apnea Syndrome |
| title_short | Neuroendocrine Alterations in Obese Patients with Sleep Apnea Syndrome |
| title_sort | neuroendocrine alterations in obese patients with sleep apnea syndrome |
| url | http://dx.doi.org/10.1155/2010/474518 |
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