QSAR Studies of 6-Amino Uracil Base Analogues: A Thymidine Phosphorylase Inhibitor in Cancer Therapy
A novel series of 6-amino uracil base analogue were synthesized. QSAR study was used to relate the selective nonsubstrate inhibitory activity of 6-amino uracil base analogue with various physicochemical descriptors. Stepwise multiple regression analysis was performed to find out the correlation bet...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2008/242865 |
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| author | Surya Prakash B. N. Gupta Neeraj Upmanyu N. S. Hari Narayana Moorthy S. Bhattacharya |
| author_facet | Surya Prakash B. N. Gupta Neeraj Upmanyu N. S. Hari Narayana Moorthy S. Bhattacharya |
| author_sort | Surya Prakash B. N. Gupta |
| collection | DOAJ |
| description | A novel series of 6-amino uracil base analogue were synthesized. QSAR study was used to relate the selective nonsubstrate inhibitory activity of 6-amino uracil base analogue with various physicochemical descriptors. Stepwise multiple regression analysis was performed to find out the correlation between various physicochemical descriptors and biological activity of the compounds by using Openstat 2 version 6.5.1 and valstat statistical software. Out of the several equations developed, the best equation having the highest significance was selected for further study. The equation is able to explain 60% of total variance and are more than 95% significant as revealed by the F value. |
| format | Article |
| id | doaj-art-00c6d9409226419781275eb58a7939b9 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-00c6d9409226419781275eb58a7939b92025-02-03T01:25:38ZengWileyE-Journal of Chemistry0973-49452090-98102008-01-015118518610.1155/2008/242865QSAR Studies of 6-Amino Uracil Base Analogues: A Thymidine Phosphorylase Inhibitor in Cancer TherapySurya Prakash B. N. Gupta0Neeraj Upmanyu1N. S. Hari Narayana Moorthy2S. Bhattacharya3Rajiv Gandhi Institute of Pharmacy, Satna (M.P.)-485001., IndiaRKDF, College of Pharmacy, Bhopal (MP)-462021, IndiaSchool of Pharmaceutical Sciences, UTD, RGPV, Gandhi Nagar, Bhopal (MP)- 462036, IndiaDepartment of Pharmaceutical Sciences, BIT Mesra, Ranchi (Jharkhand), IndiaA novel series of 6-amino uracil base analogue were synthesized. QSAR study was used to relate the selective nonsubstrate inhibitory activity of 6-amino uracil base analogue with various physicochemical descriptors. Stepwise multiple regression analysis was performed to find out the correlation between various physicochemical descriptors and biological activity of the compounds by using Openstat 2 version 6.5.1 and valstat statistical software. Out of the several equations developed, the best equation having the highest significance was selected for further study. The equation is able to explain 60% of total variance and are more than 95% significant as revealed by the F value.http://dx.doi.org/10.1155/2008/242865 |
| spellingShingle | Surya Prakash B. N. Gupta Neeraj Upmanyu N. S. Hari Narayana Moorthy S. Bhattacharya QSAR Studies of 6-Amino Uracil Base Analogues: A Thymidine Phosphorylase Inhibitor in Cancer Therapy E-Journal of Chemistry |
| title | QSAR Studies of 6-Amino Uracil Base Analogues: A Thymidine Phosphorylase Inhibitor in Cancer Therapy |
| title_full | QSAR Studies of 6-Amino Uracil Base Analogues: A Thymidine Phosphorylase Inhibitor in Cancer Therapy |
| title_fullStr | QSAR Studies of 6-Amino Uracil Base Analogues: A Thymidine Phosphorylase Inhibitor in Cancer Therapy |
| title_full_unstemmed | QSAR Studies of 6-Amino Uracil Base Analogues: A Thymidine Phosphorylase Inhibitor in Cancer Therapy |
| title_short | QSAR Studies of 6-Amino Uracil Base Analogues: A Thymidine Phosphorylase Inhibitor in Cancer Therapy |
| title_sort | qsar studies of 6 amino uracil base analogues a thymidine phosphorylase inhibitor in cancer therapy |
| url | http://dx.doi.org/10.1155/2008/242865 |
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