Generation of Transplantable Beta Cells for Patient-Specific Cell Therapy
Islet cell transplantation offers a potential cure for type 1 diabetes, but it is challenged by insufficient donor tissue and side effects of current immunosuppressive drugs. Therefore, alternative sources of insulin-producing cells and isletfriendly immunosuppression are required to increase the ef...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2012/414812 |
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| _version_ | 1832545688230035456 |
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| author | Xiaojie Wang Daniel L. Metzger Mark Meloche Jianqiang Hao Ziliang Ao Garth L. Warnock |
| author_facet | Xiaojie Wang Daniel L. Metzger Mark Meloche Jianqiang Hao Ziliang Ao Garth L. Warnock |
| author_sort | Xiaojie Wang |
| collection | DOAJ |
| description | Islet cell transplantation offers a potential cure for type 1 diabetes, but it is challenged by insufficient donor tissue and side effects of current immunosuppressive drugs. Therefore, alternative sources of insulin-producing cells and isletfriendly immunosuppression are required to increase the efficiency and safety of this procedure. Beta cells can be transdifferentiated from precursors or another heterologous (non-beta-cell) source. Recent advances in beta cell regeneration from somatic cells such as fibroblasts could circumvent the usage of immunosuppressive drugs. Therefore, generation of patient-specific beta cells provides the potential of an evolutionary treatment for patients with diabetes. |
| format | Article |
| id | doaj-art-00b667b493bb4db7b7d57316e53182d0 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-00b667b493bb4db7b7d57316e53182d02025-02-03T07:24:50ZengWileyInternational Journal of Endocrinology1687-83371687-83452012-01-01201210.1155/2012/414812414812Generation of Transplantable Beta Cells for Patient-Specific Cell TherapyXiaojie Wang0Daniel L. Metzger1Mark Meloche2Jianqiang Hao3Ziliang Ao4Garth L. Warnock5Department of Surgery, University of British Columbia, 3100, 910 West 10th Avenue, Vancouver, BC, V5Z 4E3, CanadaDepartment of Pediatrics, University of British Columbia, 3100, 910 West 10th Avenue, Vancouver, BC, V5Z 4E3, CanadaDepartment of Surgery, University of British Columbia, 3100, 910 West 10th Avenue, Vancouver, BC, V5Z 4E3, CanadaDepartment of Surgery, University of British Columbia, 3100, 910 West 10th Avenue, Vancouver, BC, V5Z 4E3, CanadaDepartment of Surgery, University of British Columbia, 3100, 910 West 10th Avenue, Vancouver, BC, V5Z 4E3, CanadaDepartment of Surgery, University of British Columbia, 3100, 910 West 10th Avenue, Vancouver, BC, V5Z 4E3, CanadaIslet cell transplantation offers a potential cure for type 1 diabetes, but it is challenged by insufficient donor tissue and side effects of current immunosuppressive drugs. Therefore, alternative sources of insulin-producing cells and isletfriendly immunosuppression are required to increase the efficiency and safety of this procedure. Beta cells can be transdifferentiated from precursors or another heterologous (non-beta-cell) source. Recent advances in beta cell regeneration from somatic cells such as fibroblasts could circumvent the usage of immunosuppressive drugs. Therefore, generation of patient-specific beta cells provides the potential of an evolutionary treatment for patients with diabetes.http://dx.doi.org/10.1155/2012/414812 |
| spellingShingle | Xiaojie Wang Daniel L. Metzger Mark Meloche Jianqiang Hao Ziliang Ao Garth L. Warnock Generation of Transplantable Beta Cells for Patient-Specific Cell Therapy International Journal of Endocrinology |
| title | Generation of Transplantable Beta Cells for Patient-Specific Cell Therapy |
| title_full | Generation of Transplantable Beta Cells for Patient-Specific Cell Therapy |
| title_fullStr | Generation of Transplantable Beta Cells for Patient-Specific Cell Therapy |
| title_full_unstemmed | Generation of Transplantable Beta Cells for Patient-Specific Cell Therapy |
| title_short | Generation of Transplantable Beta Cells for Patient-Specific Cell Therapy |
| title_sort | generation of transplantable beta cells for patient specific cell therapy |
| url | http://dx.doi.org/10.1155/2012/414812 |
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