Associations of inferior frontal sulcal hyperintensities on brain MRI with cerebral small vessel disease, cognitive function, and depression symptoms

Associations of inferior frontal sulcal hyperintensities on brain MRI with cerebral small vessel disease, cognitive function, and depression symptoms

Abstract Inferior frontal sulcal hyperintensities (IFSH) observed on fluid-attenuated inversion recovery (FLAIR) MRI have been proposed as indicators of elevated cerebrospinal fluid waste accumulation in cerebral small vessel disease (CSVD). However, to validate IFSH as a reliable imaging biomarker,...

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Main Authors: Marc Dörner, Malte Pfister, Anthony Tyndall, Roland von Känel, Katja Neumann, Frank Schreiber, Philipp Arndt, Erelle Fuchs, Cornelia Garz, Wenzel Glanz, Michaela Butryn, Anna-Charlotte John, Annkatrin Hildebrand, Sebastian Euler, Andreas B. Hofmann, Lena Machetanz, Johannes Kirchebner, Pawel Tacik, Alexander Grimm, Robin Jansen, Marc Pawlitzki, Solveig Henneicke, Valentina Perosa, Bendix Labeit, Emrah Düzel, Sven G. Meuth, Stefan Vielhaber, Hendrik Mattern, Jose Bernal, Stefanie Schreiber
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Cerebral small vessel disease
Cerebral amyloid angiopathy
Hypertensive arteriopathy
Inferior frontal sulcal hyperintensity
Glymphatic system
Fluid-attenuated inversion recovery
Online Access:https://doi.org/10.1038/s41598-025-87493-8
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