Associations of inferior frontal sulcal hyperintensities on brain MRI with cerebral small vessel disease, cognitive function, and depression symptoms
Abstract Inferior frontal sulcal hyperintensities (IFSH) observed on fluid-attenuated inversion recovery (FLAIR) MRI have been proposed as indicators of elevated cerebrospinal fluid waste accumulation in cerebral small vessel disease (CSVD). However, to validate IFSH as a reliable imaging biomarker,...
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2025-01-01
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| author | Marc Dörner Malte Pfister Anthony Tyndall Roland von Känel Katja Neumann Frank Schreiber Philipp Arndt Erelle Fuchs Cornelia Garz Wenzel Glanz Michaela Butryn Anna-Charlotte John Annkatrin Hildebrand Sebastian Euler Andreas B. Hofmann Lena Machetanz Johannes Kirchebner Pawel Tacik Alexander Grimm Robin Jansen Marc Pawlitzki Solveig Henneicke Valentina Perosa Bendix Labeit Emrah Düzel Sven G. Meuth Stefan Vielhaber Hendrik Mattern Jose Bernal Stefanie Schreiber |
| author_facet | Marc Dörner Malte Pfister Anthony Tyndall Roland von Känel Katja Neumann Frank Schreiber Philipp Arndt Erelle Fuchs Cornelia Garz Wenzel Glanz Michaela Butryn Anna-Charlotte John Annkatrin Hildebrand Sebastian Euler Andreas B. Hofmann Lena Machetanz Johannes Kirchebner Pawel Tacik Alexander Grimm Robin Jansen Marc Pawlitzki Solveig Henneicke Valentina Perosa Bendix Labeit Emrah Düzel Sven G. Meuth Stefan Vielhaber Hendrik Mattern Jose Bernal Stefanie Schreiber |
| author_sort | Marc Dörner |
| collection | DOAJ |
| description | Abstract Inferior frontal sulcal hyperintensities (IFSH) observed on fluid-attenuated inversion recovery (FLAIR) MRI have been proposed as indicators of elevated cerebrospinal fluid waste accumulation in cerebral small vessel disease (CSVD). However, to validate IFSH as a reliable imaging biomarker, further replication studies are required. The objective of this study was to investigate associations between IFSH and CSVD, and their potential repercussions, i.e., cognitive impairment and depression. We prospectively recruited 47 patients with CSVD and 29 cognitively normal controls (NC). IFSH were rated visually based on FLAIR MRI. Using different regression models, we explored the relationship between IFSH, group status (CSVD vs. NC), CSVD severity assessed with MRI, cognitive function, and symptoms of depression. Patients with CSVD were more likely to have higher IFSH scores compared to NC (OR 5.64, 95% CI 1.91–16.60), and greater CSVD severity on MRI predicted more severe IFSH (OR 1.47, 95% CI 1.14–1.88). Higher IFSH scores were associated with lower cognitive function (-0.96, 95% CI -1.81 to -0.10), and higher levels of depression (0.33, 95% CI 0.01–0.65). CSVD and IFSH may be tightly linked to each other, and the accumulation of waste products, indicated by IFSH, could have detrimental effects on cognitive function and symptoms of depression. |
| format | Article |
| id | doaj-art-00b2c5ecd16646d4acedfd513ac87e06 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-00b2c5ecd16646d4acedfd513ac87e062025-01-26T12:31:49ZengNature PortfolioScientific Reports2045-23222025-01-0115111010.1038/s41598-025-87493-8Associations of inferior frontal sulcal hyperintensities on brain MRI with cerebral small vessel disease, cognitive function, and depression symptomsMarc Dörner0Malte Pfister1Anthony Tyndall2Roland von Känel3Katja Neumann4Frank Schreiber5Philipp Arndt6Erelle Fuchs7Cornelia Garz8Wenzel Glanz9Michaela Butryn10Anna-Charlotte John11Annkatrin Hildebrand12Sebastian Euler13Andreas B. Hofmann14Lena Machetanz15Johannes Kirchebner16Pawel Tacik17Alexander Grimm18Robin Jansen19Marc Pawlitzki20Solveig Henneicke21Valentina Perosa22Bendix Labeit23Emrah Düzel24Sven G. Meuth25Stefan Vielhaber26Hendrik Mattern27Jose Bernal28Stefanie Schreiber29German Center for Neurodegenerative Diseases (DZNE) within the Helmholtz AssociationDepartment of Neurology, Otto-von-Guericke UniversityDepartment of Neuroradiology, Clinical Neuroscience Center, University Hospital Zurich, University of ZurichDepartment of Consultation-Liaison-Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of ZurichDepartment of Neurology, Otto-von-Guericke UniversityGerman Center for Neurodegenerative Diseases (DZNE) within the Helmholtz AssociationGerman Center for Neurodegenerative Diseases (DZNE) within the Helmholtz AssociationDepartment of Neuroradiology, Otto-von-Guericke UniversityGerman Center for Neurodegenerative Diseases (DZNE) within the Helmholtz AssociationGerman Center for Neurodegenerative Diseases (DZNE) within the Helmholtz AssociationGerman Center for Neurodegenerative Diseases (DZNE) within the Helmholtz AssociationDepartment of Neurology, Otto-von-Guericke UniversityDepartment of Neurology, Otto-von-Guericke UniversityDepartment of Consultation-Liaison-Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of ZurichDepartment of Psychiatry, Psychotherapy, and Psychosomatics, University Hospital of Psychiatry Zurich, University of ZurichDepartment of Psychiatry, Psychotherapy, and Psychosomatics, University Hospital of Psychiatry Zurich, University of ZurichDepartment of Forensic Psychiatry, University Hospital of Psychiatry Zurich, University of ZurichDepartment of Parkinson’s Disease, Sleep and Movement Disorders, University Hospital BonnCenter for Neurology, Tuebingen University Hospital and Hertie-Institute for Clinical Brain Research, Eberhard Karls UniversityDepartment of Neurology, Medical Faculty, Heinrich Heine UniversityDepartment of Neurology, Medical Faculty, Heinrich Heine UniversityGerman Center for Neurodegenerative Diseases (DZNE) within the Helmholtz AssociationMassachusetts General Hospital, J. Philip Kistler Stroke Research CenterDepartment of Neurology, Medical Faculty, Heinrich Heine UniversityGerman Center for Neurodegenerative Diseases (DZNE) within the Helmholtz AssociationDepartment of Neurology, Medical Faculty, Heinrich Heine UniversityDepartment of Neurology, Otto-von-Guericke UniversityGerman Center for Neurodegenerative Diseases (DZNE) within the Helmholtz AssociationGerman Center for Neurodegenerative Diseases (DZNE) within the Helmholtz AssociationGerman Center for Neurodegenerative Diseases (DZNE) within the Helmholtz AssociationAbstract Inferior frontal sulcal hyperintensities (IFSH) observed on fluid-attenuated inversion recovery (FLAIR) MRI have been proposed as indicators of elevated cerebrospinal fluid waste accumulation in cerebral small vessel disease (CSVD). However, to validate IFSH as a reliable imaging biomarker, further replication studies are required. The objective of this study was to investigate associations between IFSH and CSVD, and their potential repercussions, i.e., cognitive impairment and depression. We prospectively recruited 47 patients with CSVD and 29 cognitively normal controls (NC). IFSH were rated visually based on FLAIR MRI. Using different regression models, we explored the relationship between IFSH, group status (CSVD vs. NC), CSVD severity assessed with MRI, cognitive function, and symptoms of depression. Patients with CSVD were more likely to have higher IFSH scores compared to NC (OR 5.64, 95% CI 1.91–16.60), and greater CSVD severity on MRI predicted more severe IFSH (OR 1.47, 95% CI 1.14–1.88). Higher IFSH scores were associated with lower cognitive function (-0.96, 95% CI -1.81 to -0.10), and higher levels of depression (0.33, 95% CI 0.01–0.65). CSVD and IFSH may be tightly linked to each other, and the accumulation of waste products, indicated by IFSH, could have detrimental effects on cognitive function and symptoms of depression.https://doi.org/10.1038/s41598-025-87493-8Cerebral small vessel diseaseCerebral amyloid angiopathyHypertensive arteriopathyInferior frontal sulcal hyperintensityGlymphatic systemFluid-attenuated inversion recovery |
| spellingShingle | Marc Dörner Malte Pfister Anthony Tyndall Roland von Känel Katja Neumann Frank Schreiber Philipp Arndt Erelle Fuchs Cornelia Garz Wenzel Glanz Michaela Butryn Anna-Charlotte John Annkatrin Hildebrand Sebastian Euler Andreas B. Hofmann Lena Machetanz Johannes Kirchebner Pawel Tacik Alexander Grimm Robin Jansen Marc Pawlitzki Solveig Henneicke Valentina Perosa Bendix Labeit Emrah Düzel Sven G. Meuth Stefan Vielhaber Hendrik Mattern Jose Bernal Stefanie Schreiber Associations of inferior frontal sulcal hyperintensities on brain MRI with cerebral small vessel disease, cognitive function, and depression symptoms Scientific Reports Cerebral small vessel disease Cerebral amyloid angiopathy Hypertensive arteriopathy Inferior frontal sulcal hyperintensity Glymphatic system Fluid-attenuated inversion recovery |
| title | Associations of inferior frontal sulcal hyperintensities on brain MRI with cerebral small vessel disease, cognitive function, and depression symptoms |
| title_full | Associations of inferior frontal sulcal hyperintensities on brain MRI with cerebral small vessel disease, cognitive function, and depression symptoms |
| title_fullStr | Associations of inferior frontal sulcal hyperintensities on brain MRI with cerebral small vessel disease, cognitive function, and depression symptoms |
| title_full_unstemmed | Associations of inferior frontal sulcal hyperintensities on brain MRI with cerebral small vessel disease, cognitive function, and depression symptoms |
| title_short | Associations of inferior frontal sulcal hyperintensities on brain MRI with cerebral small vessel disease, cognitive function, and depression symptoms |
| title_sort | associations of inferior frontal sulcal hyperintensities on brain mri with cerebral small vessel disease cognitive function and depression symptoms |
| topic | Cerebral small vessel disease Cerebral amyloid angiopathy Hypertensive arteriopathy Inferior frontal sulcal hyperintensity Glymphatic system Fluid-attenuated inversion recovery |
| url | https://doi.org/10.1038/s41598-025-87493-8 |
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