Association of Inflammatory and Oxidative Stress Markers with Metabolic Syndrome in Asian Indians in India
Metabolic syndrome (MetS) is a primary risk factor for cardiovascular disease and is associated with a proinflammatory state. Here, we assessed the contribution of inflammatory and oxidative stress markers towards prediction of MetS. A total of 2316 individuals were recruited in Phase I of the India...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.4061/2011/295976 |
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| author | Veena S. Rao Radhika K. Nagaraj Sridhara Hebbagodi Natesha B. Kadarinarasimhiah Vijay V. Kakkar |
| author_facet | Veena S. Rao Radhika K. Nagaraj Sridhara Hebbagodi Natesha B. Kadarinarasimhiah Vijay V. Kakkar |
| author_sort | Veena S. Rao |
| collection | DOAJ |
| description | Metabolic syndrome (MetS) is a primary risk factor for cardiovascular disease and is associated with a proinflammatory state. Here, we assessed the contribution of inflammatory and oxidative stress markers towards prediction of MetS. A total of 2316 individuals were recruited in Phase I of the Indian Atherosclerosis Research Study (IARS). Modified ATPIII guidelines were used for classification of subjects with MetS. Among the inflammatory and oxidative stress markers studied, levels of hsCRP (P<.0001), Neopterin (P=.036), and oxLDL (P<.0001) were significantly higher among subjects with MetS. Among the markers we tested, oxLDL stood out as a robust predictor of MetS in the IARS population (OR 4.956 95% CI 2.504–9.810; P<.0001) followed by hsCRP (OR 1.324 95% CI 1.070–1.638; P=.010). In conclusion, oxLDL is a candidate predictor for MetS in the Asian Indian population. |
| format | Article |
| id | doaj-art-00af10d436294fb692563d170a655763 |
| institution | Kabale University |
| issn | 2090-0597 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-00af10d436294fb692563d170a6557632025-02-03T05:50:07ZengWileyCardiology Research and Practice2090-05972011-01-01201110.4061/2011/295976295976Association of Inflammatory and Oxidative Stress Markers with Metabolic Syndrome in Asian Indians in IndiaVeena S. Rao0Radhika K. Nagaraj1Sridhara Hebbagodi2Natesha B. Kadarinarasimhiah3Vijay V. Kakkar4Tata Proteomics and Coagulation Unit, Thrombosis Research Institute, Narayana Hrudayalaya, 258/A Bommasandra Industrial Area, Anekal Taluk, Bangalore 560099, IndiaEmmanuel Kaye Bioinformatics Centre, Thrombosis Research Institute, Bangalore 560099, IndiaEmmanuel Kaye Bioinformatics Centre, Thrombosis Research Institute, Bangalore 560099, IndiaTata Proteomics and Coagulation Unit, Thrombosis Research Institute, Narayana Hrudayalaya, 258/A Bommasandra Industrial Area, Anekal Taluk, Bangalore 560099, IndiaTata Proteomics and Coagulation Unit, Thrombosis Research Institute, Narayana Hrudayalaya, 258/A Bommasandra Industrial Area, Anekal Taluk, Bangalore 560099, IndiaMetabolic syndrome (MetS) is a primary risk factor for cardiovascular disease and is associated with a proinflammatory state. Here, we assessed the contribution of inflammatory and oxidative stress markers towards prediction of MetS. A total of 2316 individuals were recruited in Phase I of the Indian Atherosclerosis Research Study (IARS). Modified ATPIII guidelines were used for classification of subjects with MetS. Among the inflammatory and oxidative stress markers studied, levels of hsCRP (P<.0001), Neopterin (P=.036), and oxLDL (P<.0001) were significantly higher among subjects with MetS. Among the markers we tested, oxLDL stood out as a robust predictor of MetS in the IARS population (OR 4.956 95% CI 2.504–9.810; P<.0001) followed by hsCRP (OR 1.324 95% CI 1.070–1.638; P=.010). In conclusion, oxLDL is a candidate predictor for MetS in the Asian Indian population.http://dx.doi.org/10.4061/2011/295976 |
| spellingShingle | Veena S. Rao Radhika K. Nagaraj Sridhara Hebbagodi Natesha B. Kadarinarasimhiah Vijay V. Kakkar Association of Inflammatory and Oxidative Stress Markers with Metabolic Syndrome in Asian Indians in India Cardiology Research and Practice |
| title | Association of Inflammatory and Oxidative Stress Markers with Metabolic Syndrome in Asian Indians in India |
| title_full | Association of Inflammatory and Oxidative Stress Markers with Metabolic Syndrome in Asian Indians in India |
| title_fullStr | Association of Inflammatory and Oxidative Stress Markers with Metabolic Syndrome in Asian Indians in India |
| title_full_unstemmed | Association of Inflammatory and Oxidative Stress Markers with Metabolic Syndrome in Asian Indians in India |
| title_short | Association of Inflammatory and Oxidative Stress Markers with Metabolic Syndrome in Asian Indians in India |
| title_sort | association of inflammatory and oxidative stress markers with metabolic syndrome in asian indians in india |
| url | http://dx.doi.org/10.4061/2011/295976 |
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