Experimental approbation of a new ultrosound contrast agent based on sulfur geksafluoride in diagnostics of focal liver lesions of inflammatory genesis
Purpose of the study. Experimental approbation of a new domestic ultrasound contrast agent (UCA) based on sulfur hexafluoride in the diagnosis of focal liver lesions of inflammatory genesis.Materials and methods. The investigated ultrasound contrast agent (UCA) was a heterogeneous gas-liquid system...
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Siberian State Medical University (Tomsk)
2017-04-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/779 |
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| author | S. V. Fomina V. D. Zavadovskay A. A. Churin M. S. Jusubov |
| author_facet | S. V. Fomina V. D. Zavadovskay A. A. Churin M. S. Jusubov |
| author_sort | S. V. Fomina |
| collection | DOAJ |
| description | Purpose of the study. Experimental approbation of a new domestic ultrasound contrast agent (UCA) based on sulfur hexafluoride in the diagnosis of focal liver lesions of inflammatory genesis.Materials and methods. The investigated ultrasound contrast agent (UCA) was a heterogeneous gas-liquid system consisting of micro bubbles of a sparingly soluble gas of sulfur hexafluoride (SF6) surrounded by a flexible mobile membrane of surfactants. Experimental work was carried out on rabbits. The study group included rabbits of males and females with focal liver lesion of inflammatory genesis (n = 12) weighing 1500- 1700 g. UCA was administered to animals in the ear vein. Focal lesions of the liver in animals were created in the experimental laboratory conditions. 14 days after the operation, all animals were subjected to ultrasound examination of the surgical intervention zones by using the Toshiba Aplio 400 scanners (Japan) with a 3,5–8 MHz convection sensor. In a natural study, the size, structure and echogenicity of the focus were assessed, the degree of vascularization, the evenness and clarity of the contours were determined. When performing post contrast ultrasound, the time of the onset of contrast enhancement, the total duration of contrast, the changes in the contrast enhancement of the focus in different phases of the study were measured, the dimensions of the focus were measured, and the evenness and acuity of contours were measured. For histological examination, liver fragments and lungs were used. |
| format | Article |
| id | doaj-art-00aec17188074d66a15bb4f2e605fe1a |
| institution | DOAJ |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2017-04-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-00aec17188074d66a15bb4f2e605fe1a2025-08-20T03:02:06ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842017-04-0116110110710.20538/1682-0363-2017-1-101-107627Experimental approbation of a new ultrosound contrast agent based on sulfur geksafluoride in diagnostics of focal liver lesions of inflammatory genesisS. V. Fomina0V. D. Zavadovskay1A. A. Churin2M. S. Jusubov3Siberian Medical State University (SSMU)Siberian Medical State University (SSMU)Research Institute of Pharmacology and Regenerative Medicine named E.D. Goldberg, Tomsk National Research Medical Center (TNRMC), Russian Academy of Sciences (RAS)Siberian Medical State University (SSMU)Purpose of the study. Experimental approbation of a new domestic ultrasound contrast agent (UCA) based on sulfur hexafluoride in the diagnosis of focal liver lesions of inflammatory genesis.Materials and methods. The investigated ultrasound contrast agent (UCA) was a heterogeneous gas-liquid system consisting of micro bubbles of a sparingly soluble gas of sulfur hexafluoride (SF6) surrounded by a flexible mobile membrane of surfactants. Experimental work was carried out on rabbits. The study group included rabbits of males and females with focal liver lesion of inflammatory genesis (n = 12) weighing 1500- 1700 g. UCA was administered to animals in the ear vein. Focal lesions of the liver in animals were created in the experimental laboratory conditions. 14 days after the operation, all animals were subjected to ultrasound examination of the surgical intervention zones by using the Toshiba Aplio 400 scanners (Japan) with a 3,5–8 MHz convection sensor. In a natural study, the size, structure and echogenicity of the focus were assessed, the degree of vascularization, the evenness and clarity of the contours were determined. When performing post contrast ultrasound, the time of the onset of contrast enhancement, the total duration of contrast, the changes in the contrast enhancement of the focus in different phases of the study were measured, the dimensions of the focus were measured, and the evenness and acuity of contours were measured. For histological examination, liver fragments and lungs were used.https://bulletin.ssmu.ru/jour/article/view/779ultrasound diagnosisechocontrast preparationsmicrobubblesphasic contrastingacoustic resistancefocal formations |
| spellingShingle | S. V. Fomina V. D. Zavadovskay A. A. Churin M. S. Jusubov Experimental approbation of a new ultrosound contrast agent based on sulfur geksafluoride in diagnostics of focal liver lesions of inflammatory genesis Бюллетень сибирской медицины ultrasound diagnosis echocontrast preparations microbubbles phasic contrasting acoustic resistance focal formations |
| title | Experimental approbation of a new ultrosound contrast agent based on sulfur geksafluoride in diagnostics of focal liver lesions of inflammatory genesis |
| title_full | Experimental approbation of a new ultrosound contrast agent based on sulfur geksafluoride in diagnostics of focal liver lesions of inflammatory genesis |
| title_fullStr | Experimental approbation of a new ultrosound contrast agent based on sulfur geksafluoride in diagnostics of focal liver lesions of inflammatory genesis |
| title_full_unstemmed | Experimental approbation of a new ultrosound contrast agent based on sulfur geksafluoride in diagnostics of focal liver lesions of inflammatory genesis |
| title_short | Experimental approbation of a new ultrosound contrast agent based on sulfur geksafluoride in diagnostics of focal liver lesions of inflammatory genesis |
| title_sort | experimental approbation of a new ultrosound contrast agent based on sulfur geksafluoride in diagnostics of focal liver lesions of inflammatory genesis |
| topic | ultrasound diagnosis echocontrast preparations microbubbles phasic contrasting acoustic resistance focal formations |
| url | https://bulletin.ssmu.ru/jour/article/view/779 |
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