The Mast Cell-Aryl Hydrocarbon Receptor Interplay at the Host-Microbe Interface
Mast cells are increasingly being recognized as crucial cells in the response of the organism to environmental agents. Interestingly, the ability of mast cells to sense and respond to external cues is modulated by the microenvironment that surrounds mast cells and influences their differentiation. T...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/7396136 |
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| author | Claudio Costantini Giorgia Renga Vasilis Oikonomou Giuseppe Paolicelli Monica Borghi Marilena Pariano Antonella De Luca Matteo Puccetti Claudia Stincardini Paolo Mosci Andrea Bartoli Teresa Zelante Luigina Romani |
| author_facet | Claudio Costantini Giorgia Renga Vasilis Oikonomou Giuseppe Paolicelli Monica Borghi Marilena Pariano Antonella De Luca Matteo Puccetti Claudia Stincardini Paolo Mosci Andrea Bartoli Teresa Zelante Luigina Romani |
| author_sort | Claudio Costantini |
| collection | DOAJ |
| description | Mast cells are increasingly being recognized as crucial cells in the response of the organism to environmental agents. Interestingly, the ability of mast cells to sense and respond to external cues is modulated by the microenvironment that surrounds mast cells and influences their differentiation. The scenario that is emerging unveils a delicate equilibrium that balances the effector functions of mast cells to guarantee host protection without compromising tissue homeostasis. Among the environmental components able to mold mast cells and fine-tune their effector functions, the microorganisms that colonize the human body, collectively known as microbiome, certainly play a key role. Indeed, microorganisms can regulate not only the survival, recruitment, and maturation of mast cells but also their activity by setting the threshold required for the exploitation of their different effector functions. Herein, we summarize the current knowledge about the mechanisms underlying the ability of the microorganisms to regulate mast cell physiology and discuss potential deviations that result in pathological consequences. We will discuss the pivotal role of the aryl hydrocarbon receptor in sensing the environment and shaping mast cell adaptation at the host-microbe interface. |
| format | Article |
| id | doaj-art-00ae826d976541249635eaf884886a59 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-00ae826d976541249635eaf884886a592025-02-03T05:47:07ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/73961367396136The Mast Cell-Aryl Hydrocarbon Receptor Interplay at the Host-Microbe InterfaceClaudio Costantini0Giorgia Renga1Vasilis Oikonomou2Giuseppe Paolicelli3Monica Borghi4Marilena Pariano5Antonella De Luca6Matteo Puccetti7Claudia Stincardini8Paolo Mosci9Andrea Bartoli10Teresa Zelante11Luigina Romani12Department of Experimental Medicine, University of Perugia, Perugia 06132, ItalyDepartment of Experimental Medicine, University of Perugia, Perugia 06132, ItalyDepartment of Experimental Medicine, University of Perugia, Perugia 06132, ItalyDepartment of Experimental Medicine, University of Perugia, Perugia 06132, ItalyDepartment of Experimental Medicine, University of Perugia, Perugia 06132, ItalyDepartment of Experimental Medicine, University of Perugia, Perugia 06132, ItalyDepartment of Experimental Medicine, University of Perugia, Perugia 06132, ItalyDepartment of Pharmaceutical Science, University of Perugia, Perugia 06132, ItalyDepartment of Experimental Medicine, University of Perugia, Perugia 06132, ItalyDepartment of Veterinary Medicine, University of Perugia, Perugia 06132, ItalyDepartment of Experimental Medicine, University of Perugia, Perugia 06132, ItalyDepartment of Experimental Medicine, University of Perugia, Perugia 06132, ItalyDepartment of Experimental Medicine, University of Perugia, Perugia 06132, ItalyMast cells are increasingly being recognized as crucial cells in the response of the organism to environmental agents. Interestingly, the ability of mast cells to sense and respond to external cues is modulated by the microenvironment that surrounds mast cells and influences their differentiation. The scenario that is emerging unveils a delicate equilibrium that balances the effector functions of mast cells to guarantee host protection without compromising tissue homeostasis. Among the environmental components able to mold mast cells and fine-tune their effector functions, the microorganisms that colonize the human body, collectively known as microbiome, certainly play a key role. Indeed, microorganisms can regulate not only the survival, recruitment, and maturation of mast cells but also their activity by setting the threshold required for the exploitation of their different effector functions. Herein, we summarize the current knowledge about the mechanisms underlying the ability of the microorganisms to regulate mast cell physiology and discuss potential deviations that result in pathological consequences. We will discuss the pivotal role of the aryl hydrocarbon receptor in sensing the environment and shaping mast cell adaptation at the host-microbe interface.http://dx.doi.org/10.1155/2018/7396136 |
| spellingShingle | Claudio Costantini Giorgia Renga Vasilis Oikonomou Giuseppe Paolicelli Monica Borghi Marilena Pariano Antonella De Luca Matteo Puccetti Claudia Stincardini Paolo Mosci Andrea Bartoli Teresa Zelante Luigina Romani The Mast Cell-Aryl Hydrocarbon Receptor Interplay at the Host-Microbe Interface Mediators of Inflammation |
| title | The Mast Cell-Aryl Hydrocarbon Receptor Interplay at the Host-Microbe Interface |
| title_full | The Mast Cell-Aryl Hydrocarbon Receptor Interplay at the Host-Microbe Interface |
| title_fullStr | The Mast Cell-Aryl Hydrocarbon Receptor Interplay at the Host-Microbe Interface |
| title_full_unstemmed | The Mast Cell-Aryl Hydrocarbon Receptor Interplay at the Host-Microbe Interface |
| title_short | The Mast Cell-Aryl Hydrocarbon Receptor Interplay at the Host-Microbe Interface |
| title_sort | mast cell aryl hydrocarbon receptor interplay at the host microbe interface |
| url | http://dx.doi.org/10.1155/2018/7396136 |
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