Photocatalytic Bilateral Disulfuration of Thioethers Toward α‐Sulfide Disulfides With Antibacterial Activity
Abstract α−Sulfide disulfides represent valuable motifs in organic and pharmaceutical chemistry. However, the limited availability of synthetic approaches for α−sulfide disulfides has impeded progress in this field. In this study, a photocatalytic approach to synthesizing modifiable α−sulfide disulf...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-07-01
|
| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202502862 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850101470785961984 |
|---|---|
| author | Qingqiang Tian Chuxia Wang Bingrui Liu Xiangwei Wu Yahui Li |
| author_facet | Qingqiang Tian Chuxia Wang Bingrui Liu Xiangwei Wu Yahui Li |
| author_sort | Qingqiang Tian |
| collection | DOAJ |
| description | Abstract α−Sulfide disulfides represent valuable motifs in organic and pharmaceutical chemistry. However, the limited availability of synthetic approaches for α−sulfide disulfides has impeded progress in this field. In this study, a photocatalytic approach to synthesizing modifiable α−sulfide disulfides is presented using accessible sulfides and a bilateral disulfurating reagent. The reaction proceeds under mild conditions and demonstrates broad substrate compatibility, accommodating both aromatic and aliphatic sulfides. Moreover, the synthesized α−sulfide disulfides display robust reactivity in subsequent transformations with different electrophiles. Notably, this protocol can also be applied to the modification of polymer matrices. Bioassays further reveal that certain target compounds exhibit significant antibacterial activity against plant pathogens, such as Xanthomonas oryzae pv. oryzae (Xoo), Xanthomonas oryzae pathovar oryzicola (Xoc), and Dickeya zeae (D. zeae). |
| format | Article |
| id | doaj-art-00a096fc25434cef9533bd993556590e |
| institution | DOAJ |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-00a096fc25434cef9533bd993556590e2025-08-20T02:40:00ZengWileyAdvanced Science2198-38442025-07-011227n/an/a10.1002/advs.202502862Photocatalytic Bilateral Disulfuration of Thioethers Toward α‐Sulfide Disulfides With Antibacterial ActivityQingqiang Tian0Chuxia Wang1Bingrui Liu2Xiangwei Wu3Yahui Li4Anhui Provincial Key Laboratory of Hazardous Factors and Risk Control of Agri‐food Quality Safety Anhui Agricultural University Hefei 230036 ChinaAnhui Provincial Key Laboratory of Hazardous Factors and Risk Control of Agri‐food Quality Safety Anhui Agricultural University Hefei 230036 ChinaAnhui Provincial Key Laboratory of Hazardous Factors and Risk Control of Agri‐food Quality Safety Anhui Agricultural University Hefei 230036 ChinaAnhui Provincial Key Laboratory of Hazardous Factors and Risk Control of Agri‐food Quality Safety Anhui Agricultural University Hefei 230036 ChinaAnhui Provincial Key Laboratory of Hazardous Factors and Risk Control of Agri‐food Quality Safety Anhui Agricultural University Hefei 230036 ChinaAbstract α−Sulfide disulfides represent valuable motifs in organic and pharmaceutical chemistry. However, the limited availability of synthetic approaches for α−sulfide disulfides has impeded progress in this field. In this study, a photocatalytic approach to synthesizing modifiable α−sulfide disulfides is presented using accessible sulfides and a bilateral disulfurating reagent. The reaction proceeds under mild conditions and demonstrates broad substrate compatibility, accommodating both aromatic and aliphatic sulfides. Moreover, the synthesized α−sulfide disulfides display robust reactivity in subsequent transformations with different electrophiles. Notably, this protocol can also be applied to the modification of polymer matrices. Bioassays further reveal that certain target compounds exhibit significant antibacterial activity against plant pathogens, such as Xanthomonas oryzae pv. oryzae (Xoo), Xanthomonas oryzae pathovar oryzicola (Xoc), and Dickeya zeae (D. zeae).https://doi.org/10.1002/advs.202502862antibacterial activitybilateral disulfurating reagentphotocatalysisthioether C(sp3)−H bond polysulfidationα−sulfide disulfides |
| spellingShingle | Qingqiang Tian Chuxia Wang Bingrui Liu Xiangwei Wu Yahui Li Photocatalytic Bilateral Disulfuration of Thioethers Toward α‐Sulfide Disulfides With Antibacterial Activity Advanced Science antibacterial activity bilateral disulfurating reagent photocatalysis thioether C(sp3)−H bond polysulfidation α−sulfide disulfides |
| title | Photocatalytic Bilateral Disulfuration of Thioethers Toward α‐Sulfide Disulfides With Antibacterial Activity |
| title_full | Photocatalytic Bilateral Disulfuration of Thioethers Toward α‐Sulfide Disulfides With Antibacterial Activity |
| title_fullStr | Photocatalytic Bilateral Disulfuration of Thioethers Toward α‐Sulfide Disulfides With Antibacterial Activity |
| title_full_unstemmed | Photocatalytic Bilateral Disulfuration of Thioethers Toward α‐Sulfide Disulfides With Antibacterial Activity |
| title_short | Photocatalytic Bilateral Disulfuration of Thioethers Toward α‐Sulfide Disulfides With Antibacterial Activity |
| title_sort | photocatalytic bilateral disulfuration of thioethers toward α sulfide disulfides with antibacterial activity |
| topic | antibacterial activity bilateral disulfurating reagent photocatalysis thioether C(sp3)−H bond polysulfidation α−sulfide disulfides |
| url | https://doi.org/10.1002/advs.202502862 |
| work_keys_str_mv | AT qingqiangtian photocatalyticbilateraldisulfurationofthioetherstowardasulfidedisulfideswithantibacterialactivity AT chuxiawang photocatalyticbilateraldisulfurationofthioetherstowardasulfidedisulfideswithantibacterialactivity AT bingruiliu photocatalyticbilateraldisulfurationofthioetherstowardasulfidedisulfideswithantibacterialactivity AT xiangweiwu photocatalyticbilateraldisulfurationofthioetherstowardasulfidedisulfideswithantibacterialactivity AT yahuili photocatalyticbilateraldisulfurationofthioetherstowardasulfidedisulfideswithantibacterialactivity |