Understanding tinnitus symptom dynamics and clinical improvement through intensive longitudinal data
Abstract Intensive longitudinal sampling enhances subjective data collection by capturing real-time, dynamic inputs in natural settings, complementing traditional methods. This study evaluates the feasibility of using daily self-reported app data to assess clinical improvement among tinnitus patient...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | npj Digital Medicine |
| Online Access: | https://doi.org/10.1038/s41746-024-01425-w |
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| author | Milena Engelke Jorge Piano Simões Laura Basso Nina Wunder Berthold Langguth Thomas Probst Rüdiger Pryss Winfried Schlee |
| author_facet | Milena Engelke Jorge Piano Simões Laura Basso Nina Wunder Berthold Langguth Thomas Probst Rüdiger Pryss Winfried Schlee |
| author_sort | Milena Engelke |
| collection | DOAJ |
| description | Abstract Intensive longitudinal sampling enhances subjective data collection by capturing real-time, dynamic inputs in natural settings, complementing traditional methods. This study evaluates the feasibility of using daily self-reported app data to assess clinical improvement among tinnitus patients undergoing treatment. App data from a multi-center randomized clinical trial were analysed using time-series feature extraction and nested cross-validated ordinal regression with elastic net regulation to predict clinical improvement based on the Clinical Global Impression—Improvement scale (CGI-I). With 50% app compliance (N = 129, 8480 entries), the model demonstrated good fit to the test data (McFadden R2 = 0.82) suggesting its generalizability. Clinical improvement was associated with linear declines in tinnitus-related thoughts, jaw tension, tinnitus loudness, increases in happiness, and variability changes in tinnitus loudness and distress. These findings suggest that daily self-reported data on tinnitus symptoms is sensitive to treatment response and provides insights into specific symptom changes that occur during treatment. |
| format | Article |
| id | doaj-art-008d6145780244e0adeb5d6db6e9769b |
| institution | Kabale University |
| issn | 2398-6352 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Digital Medicine |
| spelling | doaj-art-008d6145780244e0adeb5d6db6e9769b2025-01-19T12:39:48ZengNature Portfolionpj Digital Medicine2398-63522025-01-01811810.1038/s41746-024-01425-wUnderstanding tinnitus symptom dynamics and clinical improvement through intensive longitudinal dataMilena Engelke0Jorge Piano Simões1Laura Basso2Nina Wunder3Berthold Langguth4Thomas Probst5Rüdiger Pryss6Winfried Schlee7Department of Psychiatry and Psychotherapy, University of RegensburgDepartment of Psychology, Health and Technology, University of TwenteDepartment of Psychiatry and Psychotherapy, University of RegensburgDepartment of Psychiatry and Psychotherapy, University of RegensburgDepartment of Psychiatry and Psychotherapy, University of RegensburgDepartment of Psychology, Paris Lodron University SalzburgInstitute of Clinical Epidemiology and Biometry, University of WürzburgDepartment of Psychiatry and Psychotherapy, University of RegensburgAbstract Intensive longitudinal sampling enhances subjective data collection by capturing real-time, dynamic inputs in natural settings, complementing traditional methods. This study evaluates the feasibility of using daily self-reported app data to assess clinical improvement among tinnitus patients undergoing treatment. App data from a multi-center randomized clinical trial were analysed using time-series feature extraction and nested cross-validated ordinal regression with elastic net regulation to predict clinical improvement based on the Clinical Global Impression—Improvement scale (CGI-I). With 50% app compliance (N = 129, 8480 entries), the model demonstrated good fit to the test data (McFadden R2 = 0.82) suggesting its generalizability. Clinical improvement was associated with linear declines in tinnitus-related thoughts, jaw tension, tinnitus loudness, increases in happiness, and variability changes in tinnitus loudness and distress. These findings suggest that daily self-reported data on tinnitus symptoms is sensitive to treatment response and provides insights into specific symptom changes that occur during treatment.https://doi.org/10.1038/s41746-024-01425-w |
| spellingShingle | Milena Engelke Jorge Piano Simões Laura Basso Nina Wunder Berthold Langguth Thomas Probst Rüdiger Pryss Winfried Schlee Understanding tinnitus symptom dynamics and clinical improvement through intensive longitudinal data npj Digital Medicine |
| title | Understanding tinnitus symptom dynamics and clinical improvement through intensive longitudinal data |
| title_full | Understanding tinnitus symptom dynamics and clinical improvement through intensive longitudinal data |
| title_fullStr | Understanding tinnitus symptom dynamics and clinical improvement through intensive longitudinal data |
| title_full_unstemmed | Understanding tinnitus symptom dynamics and clinical improvement through intensive longitudinal data |
| title_short | Understanding tinnitus symptom dynamics and clinical improvement through intensive longitudinal data |
| title_sort | understanding tinnitus symptom dynamics and clinical improvement through intensive longitudinal data |
| url | https://doi.org/10.1038/s41746-024-01425-w |
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