Cognitive Intraindividual Variability and White Matter Integrity in Aging
The intraindividual variability (IIV) of cognitive performance has been shown to increase with aging. While brain research has generally focused on mean performance, little is known about neural correlates of cognitive IIV. Nevertheless, some studies suggest that IIV relates more strongly than mean...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/350623 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850232387406921728 |
|---|---|
| author | Nathalie Mella Sandrine de Ribaupierre Roy Eagleson Anik de Ribaupierre |
| author_facet | Nathalie Mella Sandrine de Ribaupierre Roy Eagleson Anik de Ribaupierre |
| author_sort | Nathalie Mella |
| collection | DOAJ |
| description | The intraindividual variability (IIV) of cognitive performance has been shown to increase with aging. While brain research has generally focused on mean performance, little is known about neural correlates of cognitive IIV. Nevertheless, some studies suggest that IIV relates more strongly than mean level of performance to the quality of white matter (WM). Our study aims to explore the relation between WM integrity and cognitive IIV by combining functional (fMRI) and structural (diffusion tensor imaging, DTI) imaging. Twelve young adults (aged 18–30 years) and thirteen older adults (61–82 years) underwent a battery of neuropsychological tasks, along with fMRI and DTI imaging. Their behavioral data were analyzed and correlated with the imaging data at WM regions of interest defined on the basis of (1) the fMRI-activated areas and (2) the Johns Hopkins University (JHU) WM tractography atlas. For both methods, fractional anisotropy, along with the mean, radial, and axial diffusivity parameters, was computed. In accord with previous studies, our results showed that the DTI parameters were more related to IIV than to mean performance. Results also indicated that age differences in the DTI parameters were more pronounced in the regions activated primarily by young adults during a choice reaction-time task than in those also activated in older adults. |
| format | Article |
| id | doaj-art-007b1a7332ee4e0686d4fe22c8a7f6fc |
| institution | OA Journals |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-007b1a7332ee4e0686d4fe22c8a7f6fc2025-08-20T02:03:13ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/350623350623Cognitive Intraindividual Variability and White Matter Integrity in AgingNathalie Mella0Sandrine de Ribaupierre1Roy Eagleson2Anik de Ribaupierre3FPSE, University of Geneva, Boul du Pont d’Arve 40, 1211 Geneva 4, SwitzerlandClinical Neurological Sciences, Western University, 339 Windermere Road, London, ON, N6A 5A5, CanadaElectrical and Computer Engineering, Western University, 1151 Richmond Street, London, ON, N6A 3K7, CanadaFPSE, University of Geneva, Boul du Pont d’Arve 40, 1211 Geneva 4, SwitzerlandThe intraindividual variability (IIV) of cognitive performance has been shown to increase with aging. While brain research has generally focused on mean performance, little is known about neural correlates of cognitive IIV. Nevertheless, some studies suggest that IIV relates more strongly than mean level of performance to the quality of white matter (WM). Our study aims to explore the relation between WM integrity and cognitive IIV by combining functional (fMRI) and structural (diffusion tensor imaging, DTI) imaging. Twelve young adults (aged 18–30 years) and thirteen older adults (61–82 years) underwent a battery of neuropsychological tasks, along with fMRI and DTI imaging. Their behavioral data were analyzed and correlated with the imaging data at WM regions of interest defined on the basis of (1) the fMRI-activated areas and (2) the Johns Hopkins University (JHU) WM tractography atlas. For both methods, fractional anisotropy, along with the mean, radial, and axial diffusivity parameters, was computed. In accord with previous studies, our results showed that the DTI parameters were more related to IIV than to mean performance. Results also indicated that age differences in the DTI parameters were more pronounced in the regions activated primarily by young adults during a choice reaction-time task than in those also activated in older adults.http://dx.doi.org/10.1155/2013/350623 |
| spellingShingle | Nathalie Mella Sandrine de Ribaupierre Roy Eagleson Anik de Ribaupierre Cognitive Intraindividual Variability and White Matter Integrity in Aging The Scientific World Journal |
| title | Cognitive Intraindividual Variability and White Matter Integrity in Aging |
| title_full | Cognitive Intraindividual Variability and White Matter Integrity in Aging |
| title_fullStr | Cognitive Intraindividual Variability and White Matter Integrity in Aging |
| title_full_unstemmed | Cognitive Intraindividual Variability and White Matter Integrity in Aging |
| title_short | Cognitive Intraindividual Variability and White Matter Integrity in Aging |
| title_sort | cognitive intraindividual variability and white matter integrity in aging |
| url | http://dx.doi.org/10.1155/2013/350623 |
| work_keys_str_mv | AT nathaliemella cognitiveintraindividualvariabilityandwhitematterintegrityinaging AT sandrinederibaupierre cognitiveintraindividualvariabilityandwhitematterintegrityinaging AT royeagleson cognitiveintraindividualvariabilityandwhitematterintegrityinaging AT anikderibaupierre cognitiveintraindividualvariabilityandwhitematterintegrityinaging |