TLR4 as a therapeutic target: Antidepressant mechanism of saikosaponin A in regulating the NF-κB/BDNF axis and mitigating oxidative stress and inflammation in vivo and in vitro

TLR4 as a therapeutic target: Antidepressant mechanism of saikosaponin A in regulating the NF-κB/BDNF axis and mitigating oxidative stress and inflammation in vivo and in vitro

Natural plant-derived active ingredients have gained increasing attention for their potential in the treatment of depression due to their safety and multi-target pharmacological activities. Saikosaponin A (SSA), a major bioactive saponin extracted from Bupleurum (a medicine and food homologous plant...

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Bibliographic Details
Main Authors: Lin Tan, Jiayue Li, Dingcheng Sun, Xinyi Tian, Xiaoli Zhong, Yiyi Shan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
depression
saikosaponin A
TLR4/NF-κB/BDNF axis
neuroinflammation
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1585290/full
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