Dysregulation of transposable elements and PIWI-interacting RNAs in myelodysplastic neoplasms

Dysregulation of transposable elements and PIWI-interacting RNAs in myelodysplastic neoplasms

Abstract Background Myelodysplastic neoplasms (MDS) are heterogeneous hematopoietic disorders characterized by ineffective hematopoiesis and genome instability. Mobilization of transposable elements (TEs) is an important source of genome instability leading to oncogenesis, whereas small PIWI-interac...

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Main Authors: Zdenek Krejcik, David Kundrat, Jiri Klema, Andrea Hrustincova, Iva Trsova, Monika Belickova, Jaroslav Cermak, Anna Jonasova, Jiri Dostal, Michaela Dostalova Merkerova
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Biomarker Research
Subjects:
Myelodysplastic neoplasms
Transposable elements
piRNA
Next-generation sequencing
Biomarkers
Bioinformatics
Online Access:https://doi.org/10.1186/s40364-025-00725-x
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