Photodynamic and photothermal bacteria targeting nanosystems for synergistically combating bacteria and biofilms
Abstract The escalating hazards posed by bacterial infections underscore the imperative for pioneering advancements in next-generation antibacterial modalities and treatments. Present therapeutic methodologies are frequently impeded by the constraints of insufficient biofilm infiltration and the abs...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-025-03126-2 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832585399792304128 |
|---|---|
| author | Xiao Wang Wenxuan Shi Yu Jin Zhuoyuan Li Tanjun Deng Tingshu Su Ao Zheng Lingyan Cao |
| author_facet | Xiao Wang Wenxuan Shi Yu Jin Zhuoyuan Li Tanjun Deng Tingshu Su Ao Zheng Lingyan Cao |
| author_sort | Xiao Wang |
| collection | DOAJ |
| description | Abstract The escalating hazards posed by bacterial infections underscore the imperative for pioneering advancements in next-generation antibacterial modalities and treatments. Present therapeutic methodologies are frequently impeded by the constraints of insufficient biofilm infiltration and the absence of precision in pathogen-specific targeting. In this current study, we have used chlorin e6 (Ce6), zeolitic imidazolate framework-8 (ZIF-8), polydopamine (PDA), and UBI peptide to formulate an innovative nanosystem meticulously engineered to confront bacterial infections and effectually dismantle biofilm architectures through the concerted mechanism of photodynamic therapy (PDT)/photothermal therapy (PTT) therapies, including in-depth research, especially for oral bacteria and oral biofilm. Ce6@ZIF-8-PDA/UBI nanosystem, with effective adhesion and bacteria-targeting, affords a nuanced bacterial targeting strategy and augments penetration depth into oral biofilm matrices. The Ce6@ZIF-8-PDA/UBI nanosystem potentiated bacterial binding and aggregation. Upon exposure to red-light (RL) irradiation, Ce6@ZIF-8-PDA/UBI showed excellent antibacterial effect on S. aureus, E. coli, F. nucleatum, and P. gingivalis and exceptional light-driven antibiofilm activity to P. gingivalis biofilm, which was a result of the efficient bacterial localization mediated by PDA/UBI, as well as the PDT/PTT facilitated by Ce6/PDA interactions. Collectively, these versatile nanoplatforms augur a promising and strategic avenue for controlling infection and biofilm, thereby holding significant potential for future integration into clinical paradigms. The original application of the developed nanosystem in oral biofilms also provides a new strategy for effective oral infection treatment. |
| format | Article |
| id | doaj-art-0066b69b43714760b7c2a26cdda6499d |
| institution | Kabale University |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-0066b69b43714760b7c2a26cdda6499d2025-01-26T12:50:57ZengBMCJournal of Nanobiotechnology1477-31552025-01-0123112110.1186/s12951-025-03126-2Photodynamic and photothermal bacteria targeting nanosystems for synergistically combating bacteria and biofilmsXiao Wang0Wenxuan Shi1Yu Jin2Zhuoyuan Li3Tanjun Deng4Tingshu Su5Ao Zheng6Lingyan Cao7Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong UniversityShanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong UniversityShanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong UniversityNational Center for Stomatology, Shanghai Key Laboratory of Stomatology, Shanghai Engineering Research Center of Advanced Dental Technology and Materials, National Clinical Research Center for Oral DiseasesNational Center for Stomatology, Shanghai Key Laboratory of Stomatology, Shanghai Engineering Research Center of Advanced Dental Technology and Materials, National Clinical Research Center for Oral DiseasesShanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong UniversityShanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong UniversityShanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong UniversityAbstract The escalating hazards posed by bacterial infections underscore the imperative for pioneering advancements in next-generation antibacterial modalities and treatments. Present therapeutic methodologies are frequently impeded by the constraints of insufficient biofilm infiltration and the absence of precision in pathogen-specific targeting. In this current study, we have used chlorin e6 (Ce6), zeolitic imidazolate framework-8 (ZIF-8), polydopamine (PDA), and UBI peptide to formulate an innovative nanosystem meticulously engineered to confront bacterial infections and effectually dismantle biofilm architectures through the concerted mechanism of photodynamic therapy (PDT)/photothermal therapy (PTT) therapies, including in-depth research, especially for oral bacteria and oral biofilm. Ce6@ZIF-8-PDA/UBI nanosystem, with effective adhesion and bacteria-targeting, affords a nuanced bacterial targeting strategy and augments penetration depth into oral biofilm matrices. The Ce6@ZIF-8-PDA/UBI nanosystem potentiated bacterial binding and aggregation. Upon exposure to red-light (RL) irradiation, Ce6@ZIF-8-PDA/UBI showed excellent antibacterial effect on S. aureus, E. coli, F. nucleatum, and P. gingivalis and exceptional light-driven antibiofilm activity to P. gingivalis biofilm, which was a result of the efficient bacterial localization mediated by PDA/UBI, as well as the PDT/PTT facilitated by Ce6/PDA interactions. Collectively, these versatile nanoplatforms augur a promising and strategic avenue for controlling infection and biofilm, thereby holding significant potential for future integration into clinical paradigms. The original application of the developed nanosystem in oral biofilms also provides a new strategy for effective oral infection treatment.https://doi.org/10.1186/s12951-025-03126-2BiofilmAntibacterialPhototherapyZIF-8Ce6 |
| spellingShingle | Xiao Wang Wenxuan Shi Yu Jin Zhuoyuan Li Tanjun Deng Tingshu Su Ao Zheng Lingyan Cao Photodynamic and photothermal bacteria targeting nanosystems for synergistically combating bacteria and biofilms Journal of Nanobiotechnology Biofilm Antibacterial Phototherapy ZIF-8 Ce6 |
| title | Photodynamic and photothermal bacteria targeting nanosystems for synergistically combating bacteria and biofilms |
| title_full | Photodynamic and photothermal bacteria targeting nanosystems for synergistically combating bacteria and biofilms |
| title_fullStr | Photodynamic and photothermal bacteria targeting nanosystems for synergistically combating bacteria and biofilms |
| title_full_unstemmed | Photodynamic and photothermal bacteria targeting nanosystems for synergistically combating bacteria and biofilms |
| title_short | Photodynamic and photothermal bacteria targeting nanosystems for synergistically combating bacteria and biofilms |
| title_sort | photodynamic and photothermal bacteria targeting nanosystems for synergistically combating bacteria and biofilms |
| topic | Biofilm Antibacterial Phototherapy ZIF-8 Ce6 |
| url | https://doi.org/10.1186/s12951-025-03126-2 |
| work_keys_str_mv | AT xiaowang photodynamicandphotothermalbacteriatargetingnanosystemsforsynergisticallycombatingbacteriaandbiofilms AT wenxuanshi photodynamicandphotothermalbacteriatargetingnanosystemsforsynergisticallycombatingbacteriaandbiofilms AT yujin photodynamicandphotothermalbacteriatargetingnanosystemsforsynergisticallycombatingbacteriaandbiofilms AT zhuoyuanli photodynamicandphotothermalbacteriatargetingnanosystemsforsynergisticallycombatingbacteriaandbiofilms AT tanjundeng photodynamicandphotothermalbacteriatargetingnanosystemsforsynergisticallycombatingbacteriaandbiofilms AT tingshusu photodynamicandphotothermalbacteriatargetingnanosystemsforsynergisticallycombatingbacteriaandbiofilms AT aozheng photodynamicandphotothermalbacteriatargetingnanosystemsforsynergisticallycombatingbacteriaandbiofilms AT lingyancao photodynamicandphotothermalbacteriatargetingnanosystemsforsynergisticallycombatingbacteriaandbiofilms |