Prenatal Characteristics of Infants with a Neuronal Migration Disorder: A National-Based Study
The development of the central nervous system is complex and includes dorsal and ventral induction, neuronal proliferation, and neuronal migration, organization, and myelination. Migration occurs in humans in early fetal life. Pathogenesis of malformations of the central nervous system includes both...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2012/541892 |
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| author | Estelle Naumburg Bo Strömberg Helle Kieler |
| author_facet | Estelle Naumburg Bo Strömberg Helle Kieler |
| author_sort | Estelle Naumburg |
| collection | DOAJ |
| description | The development of the central nervous system is complex and includes dorsal and ventral induction, neuronal proliferation, and neuronal migration, organization, and myelination. Migration occurs in humans in early fetal life. Pathogenesis of malformations of the central nervous system includes both genetic and environmental factors. Few epidemiological studies have addressed the impact of prenatal exposures. All infants born alive and included in the Swedish Medical Birth Register 1980–1999 were included in the study. By linkage to the Patient Register, 820 children with a diagnosis related to a neuronal migration abnormality were identified. Through copies of referrals for computer tomography or magnetic resonance imaging of the brain, the diagnosis was confirmed in 17 children. Median age of the mothers was 29 years. At the start of pregnancy, four out of 17 women smoked. Almost half of the women had a body mass index that is low or in the lower range of average. All infants were born at term with normal birth weights. Thirteen infants had one or more concomitant diseases or malformations. Two infants were born with rubella syndrome. The impact of low maternal body mass index and congenital infections on neuronal migration disorders in infants should be addressed in future studies. |
| format | Article |
| id | doaj-art-0066928925ae40ce9de99b14bd4c2aeb |
| institution | Kabale University |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-0066928925ae40ce9de99b14bd4c2aeb2025-02-03T01:02:21ZengWileyInternational Journal of Pediatrics1687-97401687-97592012-01-01201210.1155/2012/541892541892Prenatal Characteristics of Infants with a Neuronal Migration Disorder: A National-Based StudyEstelle Naumburg0Bo Strömberg1Helle Kieler2Department of Women's and Children's Health, Uppsala University, Akademiska Sjukhuset, 751 85 Uppsala, SwedenDepartment of Women's and Children's Health, Uppsala University, Akademiska Sjukhuset, 751 85 Uppsala, SwedenDepartment of Medicine, Centre for Pharmacoepidemiology, Karolinska Institutet, 171 76 Stockholm, SwedenThe development of the central nervous system is complex and includes dorsal and ventral induction, neuronal proliferation, and neuronal migration, organization, and myelination. Migration occurs in humans in early fetal life. Pathogenesis of malformations of the central nervous system includes both genetic and environmental factors. Few epidemiological studies have addressed the impact of prenatal exposures. All infants born alive and included in the Swedish Medical Birth Register 1980–1999 were included in the study. By linkage to the Patient Register, 820 children with a diagnosis related to a neuronal migration abnormality were identified. Through copies of referrals for computer tomography or magnetic resonance imaging of the brain, the diagnosis was confirmed in 17 children. Median age of the mothers was 29 years. At the start of pregnancy, four out of 17 women smoked. Almost half of the women had a body mass index that is low or in the lower range of average. All infants were born at term with normal birth weights. Thirteen infants had one or more concomitant diseases or malformations. Two infants were born with rubella syndrome. The impact of low maternal body mass index and congenital infections on neuronal migration disorders in infants should be addressed in future studies.http://dx.doi.org/10.1155/2012/541892 |
| spellingShingle | Estelle Naumburg Bo Strömberg Helle Kieler Prenatal Characteristics of Infants with a Neuronal Migration Disorder: A National-Based Study International Journal of Pediatrics |
| title | Prenatal Characteristics of Infants with a Neuronal Migration Disorder: A National-Based Study |
| title_full | Prenatal Characteristics of Infants with a Neuronal Migration Disorder: A National-Based Study |
| title_fullStr | Prenatal Characteristics of Infants with a Neuronal Migration Disorder: A National-Based Study |
| title_full_unstemmed | Prenatal Characteristics of Infants with a Neuronal Migration Disorder: A National-Based Study |
| title_short | Prenatal Characteristics of Infants with a Neuronal Migration Disorder: A National-Based Study |
| title_sort | prenatal characteristics of infants with a neuronal migration disorder a national based study |
| url | http://dx.doi.org/10.1155/2012/541892 |
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