TREM-1 Promotes Pancreatitis-Associated Intestinal Barrier Dysfunction
Severe acute pancreatitis (SAP) can cause intestinal barrier dysfunction (IBD), which significantly increases the disease severity and risk of mortality. We hypothesized that the innate immunity- and inflammatory-related protein-triggering receptor expressed on myeloid cells-1 (TREM-1) contributes t...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/720865 |
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| author | Shengchun Dang Yao Shen Kai Yin Jianxin Zhang |
| author_facet | Shengchun Dang Yao Shen Kai Yin Jianxin Zhang |
| author_sort | Shengchun Dang |
| collection | DOAJ |
| description | Severe acute pancreatitis (SAP) can cause intestinal barrier dysfunction (IBD), which significantly increases the disease severity and risk of mortality. We hypothesized that the innate immunity- and inflammatory-related protein-triggering receptor expressed on myeloid cells-1 (TREM-1) contributes to this complication of SAP. Thus, we investigated the effect of TREM-1 pathway modulation on a rat model of pancreatitis-associated IBD. In this study we sought to clarify the role of TREM-1 in the pathophysiology of intestinal barrier dysfunction in SAP. Specifically, we evaluated levels of serum TREM-1 and membrane-bound TREM-1 in the intestine and pancreas from an animal model of experimentally induced SAP. TREM-1 pathway blockade by LP17 treatment may suppress pancreatitis-associated IBD and ameliorate the damage to the intestinal mucosa barrier. |
| format | Article |
| id | doaj-art-005f34d78c1f45d4b6322dbc49f6fba9 |
| institution | OA Journals |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-005f34d78c1f45d4b6322dbc49f6fba92025-08-20T02:03:14ZengWileyGastroenterology Research and Practice1687-61211687-630X2012-01-01201210.1155/2012/720865720865TREM-1 Promotes Pancreatitis-Associated Intestinal Barrier DysfunctionShengchun Dang0Yao Shen1Kai Yin2Jianxin Zhang3Department of General Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, ChinaSchool of Clinical Medicine, Jiangsu University, Zhenjiang 212013, ChinaDepartment of General Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, ChinaDepartment of General Surgery, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, ChinaSevere acute pancreatitis (SAP) can cause intestinal barrier dysfunction (IBD), which significantly increases the disease severity and risk of mortality. We hypothesized that the innate immunity- and inflammatory-related protein-triggering receptor expressed on myeloid cells-1 (TREM-1) contributes to this complication of SAP. Thus, we investigated the effect of TREM-1 pathway modulation on a rat model of pancreatitis-associated IBD. In this study we sought to clarify the role of TREM-1 in the pathophysiology of intestinal barrier dysfunction in SAP. Specifically, we evaluated levels of serum TREM-1 and membrane-bound TREM-1 in the intestine and pancreas from an animal model of experimentally induced SAP. TREM-1 pathway blockade by LP17 treatment may suppress pancreatitis-associated IBD and ameliorate the damage to the intestinal mucosa barrier.http://dx.doi.org/10.1155/2012/720865 |
| spellingShingle | Shengchun Dang Yao Shen Kai Yin Jianxin Zhang TREM-1 Promotes Pancreatitis-Associated Intestinal Barrier Dysfunction Gastroenterology Research and Practice |
| title | TREM-1 Promotes Pancreatitis-Associated Intestinal Barrier Dysfunction |
| title_full | TREM-1 Promotes Pancreatitis-Associated Intestinal Barrier Dysfunction |
| title_fullStr | TREM-1 Promotes Pancreatitis-Associated Intestinal Barrier Dysfunction |
| title_full_unstemmed | TREM-1 Promotes Pancreatitis-Associated Intestinal Barrier Dysfunction |
| title_short | TREM-1 Promotes Pancreatitis-Associated Intestinal Barrier Dysfunction |
| title_sort | trem 1 promotes pancreatitis associated intestinal barrier dysfunction |
| url | http://dx.doi.org/10.1155/2012/720865 |
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