Prevalence, Clinico-Demographic Profile, and Antimicrobial Susceptibility of MRSA Infections in a Tertiary Hospital in Western India: A Retrospective Study
Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) has a high prevalence in hospital settings in India and imposes a serious economic burden on healthcare resources. Understanding the local prevalence and evolving antimicrobial resistance patterns of MRSA is crucial for guiding eff...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Pasteur Institute of Iran
2024-06-01
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| Series: | Journal of Medical Microbiology and Infectious Diseases |
| Subjects: | |
| Online Access: | https://jommid.pasteur.ac.ir/article-1-648-en.html |
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| Summary: | Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) has a
high prevalence in hospital settings in India and imposes a serious economic
burden on healthcare resources. Understanding the local prevalence and
evolving antimicrobial resistance patterns of MRSA is crucial for guiding
effective treatment strategies. This study aims to determine the prevalence,
clinico-demographic profile, and antibiotic susceptibility patterns of MRSA
and methicillin-susceptible Staphylococcus aureus (MSSA) isolates.
Methods: This retrospective study analyzed Staphylococcus aureus isolates
collected between June 2021 and May 2023 from blood, pus, sterile body
fluids, respiratory, and urine samples at the Microbiology laboratory of
Mahatma Gandhi Hospital. Isolates were identified as S. aureus and tested
for methicillin resistance using the Vitek 2 Compact system, which employs
an advanced colorimetry method for identification and determines the
minimum inhibitory concentration (MIC) using a broth microdilution
method for antimicrobial susceptibility testing. Results: Of the 481
Staphylococcus aureus isolates analyzed, 264 (55%) were identified as
MRSA. Among the MRSA isolates, the most common source was
pus/wound infections (59%), followed by bloodstream infections (22%).
MRSA isolates showed a susceptibility rate of 56% to gentamicin and 45%
to clindamycin, but only 14% to ciprofloxacin. However, 55% of MSSA
isolates were resistant to ciprofloxacin. All MRSA isolates were susceptible
to daptomycin, teicoplanin, vancomycin, and linezolid. Conclusion: Our
findings underscore the need for continuous MRSA surveillance and
emphasize tailoring local antibiotic guidelines based on resistance patterns.
Targeted antimicrobial stewardship programs and reinforced infection
control protocols, especially for pus/wound infections, are crucial to curb the
spread of resistant strains. |
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| ISSN: | 2345-5349 2345-5330 |