Methods for Analyzing Multivariate Phenotypes in Genetic Association Studies
Multivariate phenotypes are frequently encountered in genetic association studies. The purpose of analyzing multivariate phenotypes usually includes discovery of novel genetic variants of pleiotropy effects, that is, affecting multiple phenotypes, and the ultimate goal of uncovering the underlying g...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Probability and Statistics |
| Online Access: | http://dx.doi.org/10.1155/2012/652569 |
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| _version_ | 1832545483033149440 |
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| author | Qiong Yang Yuanjia Wang |
| author_facet | Qiong Yang Yuanjia Wang |
| author_sort | Qiong Yang |
| collection | DOAJ |
| description | Multivariate phenotypes are frequently encountered in genetic association studies. The purpose of analyzing multivariate phenotypes usually includes discovery of novel genetic variants of pleiotropy effects, that is, affecting multiple phenotypes, and the ultimate goal of uncovering the underlying genetic mechanism. In recent years, there have been new method development and application of existing statistical methods to such phenotypes. In this paper, we provide a review of the available methods for analyzing association between a single marker and a multivariate phenotype consisting of the same type of components (e.g., all continuous or all categorical) or different types of components (e.g., some are continuous and others are categorical). We also reviewed causal inference methods designed to test whether the detected association with the multivariate phenotype is truly pleiotropy or the genetic marker exerts its effects on some phenotypes through affecting the others. |
| format | Article |
| id | doaj-art-005d70e8dff343fb8a42ff8c32d30888 |
| institution | Kabale University |
| issn | 1687-952X 1687-9538 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Probability and Statistics |
| spelling | doaj-art-005d70e8dff343fb8a42ff8c32d308882025-02-03T07:25:31ZengWileyJournal of Probability and Statistics1687-952X1687-95382012-01-01201210.1155/2012/652569652569Methods for Analyzing Multivariate Phenotypes in Genetic Association StudiesQiong Yang0Yuanjia Wang1Department of Biostatistics, Boston University School of Public Health, 810 Mass Avenue, Boston, MA 02118, USADepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY 10027, USAMultivariate phenotypes are frequently encountered in genetic association studies. The purpose of analyzing multivariate phenotypes usually includes discovery of novel genetic variants of pleiotropy effects, that is, affecting multiple phenotypes, and the ultimate goal of uncovering the underlying genetic mechanism. In recent years, there have been new method development and application of existing statistical methods to such phenotypes. In this paper, we provide a review of the available methods for analyzing association between a single marker and a multivariate phenotype consisting of the same type of components (e.g., all continuous or all categorical) or different types of components (e.g., some are continuous and others are categorical). We also reviewed causal inference methods designed to test whether the detected association with the multivariate phenotype is truly pleiotropy or the genetic marker exerts its effects on some phenotypes through affecting the others.http://dx.doi.org/10.1155/2012/652569 |
| spellingShingle | Qiong Yang Yuanjia Wang Methods for Analyzing Multivariate Phenotypes in Genetic Association Studies Journal of Probability and Statistics |
| title | Methods for Analyzing Multivariate Phenotypes in Genetic Association Studies |
| title_full | Methods for Analyzing Multivariate Phenotypes in Genetic Association Studies |
| title_fullStr | Methods for Analyzing Multivariate Phenotypes in Genetic Association Studies |
| title_full_unstemmed | Methods for Analyzing Multivariate Phenotypes in Genetic Association Studies |
| title_short | Methods for Analyzing Multivariate Phenotypes in Genetic Association Studies |
| title_sort | methods for analyzing multivariate phenotypes in genetic association studies |
| url | http://dx.doi.org/10.1155/2012/652569 |
| work_keys_str_mv | AT qiongyang methodsforanalyzingmultivariatephenotypesingeneticassociationstudies AT yuanjiawang methodsforanalyzingmultivariatephenotypesingeneticassociationstudies |