Immunomorphologic Manifestations in Mice Liver Infected with Influenza A/H5N1, A/Goose/Krasnoozerskoye/627/05 Strain
Highly pathogenic avian influenza H5N1 (HPAI H5N1) viruses can infect mammals, including humans, causing severe systemic disease with the inhibition of the immune system and a high mortality rate. In conditions of lymphoid tissue depletion, the liver plays an important role in host defence against v...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/342686 |
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| author | Oxana V. Potapova Tatyana V. Sharkova Vyacheslav A. Shkurupiy Alexander M. Shestopalov |
| author_facet | Oxana V. Potapova Tatyana V. Sharkova Vyacheslav A. Shkurupiy Alexander M. Shestopalov |
| author_sort | Oxana V. Potapova |
| collection | DOAJ |
| description | Highly pathogenic avian influenza H5N1 (HPAI H5N1) viruses can infect mammals, including humans, causing severe systemic disease with the inhibition of the immune system and a high mortality rate. In conditions of lymphoid tissue depletion, the liver plays an important role in host defence against viruses. The changes in mice liver infected with HPAI H5N1 virus A/goose/Krasnoozerskoye/627/05 have been studied. It has been shown that the virus persistence in the liver leads to the expression of proinflammatory cytokines (TNF-α, IL-6) and intracellular proteases (lysozyme, cathepsin D, and myeloperoxidase) by Kupffer cells. Defective antiviral response exacerbates destructive processes in the liver accelerating the development of liver failure. |
| format | Article |
| id | doaj-art-005c9706468645588638fea18d699188 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-005c9706468645588638fea18d6991882025-02-03T05:43:44ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/342686342686Immunomorphologic Manifestations in Mice Liver Infected with Influenza A/H5N1, A/Goose/Krasnoozerskoye/627/05 StrainOxana V. Potapova0Tatyana V. Sharkova1Vyacheslav A. Shkurupiy2Alexander M. Shestopalov3FSBI Research Center of Clinical and Experimental Medicine, SB RAMS, Timakova Street 2, Novosibirsk 630117, RussiaFSBI Research Center of Clinical and Experimental Medicine, SB RAMS, Timakova Street 2, Novosibirsk 630117, RussiaFSBI Research Center of Clinical and Experimental Medicine, SB RAMS, Timakova Street 2, Novosibirsk 630117, RussiaFSBI Research Center of Clinical and Experimental Medicine, SB RAMS, Timakova Street 2, Novosibirsk 630117, RussiaHighly pathogenic avian influenza H5N1 (HPAI H5N1) viruses can infect mammals, including humans, causing severe systemic disease with the inhibition of the immune system and a high mortality rate. In conditions of lymphoid tissue depletion, the liver plays an important role in host defence against viruses. The changes in mice liver infected with HPAI H5N1 virus A/goose/Krasnoozerskoye/627/05 have been studied. It has been shown that the virus persistence in the liver leads to the expression of proinflammatory cytokines (TNF-α, IL-6) and intracellular proteases (lysozyme, cathepsin D, and myeloperoxidase) by Kupffer cells. Defective antiviral response exacerbates destructive processes in the liver accelerating the development of liver failure.http://dx.doi.org/10.1155/2013/342686 |
| spellingShingle | Oxana V. Potapova Tatyana V. Sharkova Vyacheslav A. Shkurupiy Alexander M. Shestopalov Immunomorphologic Manifestations in Mice Liver Infected with Influenza A/H5N1, A/Goose/Krasnoozerskoye/627/05 Strain Clinical and Developmental Immunology |
| title | Immunomorphologic Manifestations in Mice Liver Infected with Influenza A/H5N1, A/Goose/Krasnoozerskoye/627/05 Strain |
| title_full | Immunomorphologic Manifestations in Mice Liver Infected with Influenza A/H5N1, A/Goose/Krasnoozerskoye/627/05 Strain |
| title_fullStr | Immunomorphologic Manifestations in Mice Liver Infected with Influenza A/H5N1, A/Goose/Krasnoozerskoye/627/05 Strain |
| title_full_unstemmed | Immunomorphologic Manifestations in Mice Liver Infected with Influenza A/H5N1, A/Goose/Krasnoozerskoye/627/05 Strain |
| title_short | Immunomorphologic Manifestations in Mice Liver Infected with Influenza A/H5N1, A/Goose/Krasnoozerskoye/627/05 Strain |
| title_sort | immunomorphologic manifestations in mice liver infected with influenza a h5n1 a goose krasnoozerskoye 627 05 strain |
| url | http://dx.doi.org/10.1155/2013/342686 |
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