Inflamm-Aging-Related Cytokines of IL-17 and IFN-γ Accelerate Osteoclastogenesis and Periodontal Destruction
Periodontal disease (PD), as an age-related disease, prevalent in middle-aged and elderly population, is characterized as inflammatory periodontal tissue loss, including gingival inflammation and alveolar bone resorption. However, the definite mechanism of aging-related inflammation in PD pathology...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/9919024 |
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| author | Jingyi Tan Anna Dai Lai Pan Lan Zhang Zhongxiu Wang Ting Ke Weilian Sun Yanmin Wu Pei-Hui Ding Lili Chen |
| author_facet | Jingyi Tan Anna Dai Lai Pan Lan Zhang Zhongxiu Wang Ting Ke Weilian Sun Yanmin Wu Pei-Hui Ding Lili Chen |
| author_sort | Jingyi Tan |
| collection | DOAJ |
| description | Periodontal disease (PD), as an age-related disease, prevalent in middle-aged and elderly population, is characterized as inflammatory periodontal tissue loss, including gingival inflammation and alveolar bone resorption. However, the definite mechanism of aging-related inflammation in PD pathology needs further investigation. Our study is aimed at exploring the effect of inflamm-aging-related cytokines of interleukin-17 (IL-17) and interferon-γ (IFN-γ) on osteoclastogenesis in vitro and periodontal destruction in vivo. For receptor activator of nuclear factor-κB ligand- (RANKL-) primed bone marrow macrophages (BMMs), IL-17 and IFN-γ enhanced osteoclastogenesis, with the expression of osteoclastogenic mRNA (TRAP, c-Fos, MMP-9, Ctsk, and NFATc1) and protein (c-Fos and MMP-9) upregulated. Ligament-induced rat models were established to investigate the role of IL-17 and IFN-γ on experimental periodontitis. Both IL-17 and IFN-γ could enhance the local inflammation in gingival tissues. Although there might be an antagonistic interaction between IL-17 and IFN-γ, IL-17 and IFN-γ could facilitate alveolar bone loss and osteoclast differentiation. |
| format | Article |
| id | doaj-art-004d84bbaac848fba3b6674ec8f2426c |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-004d84bbaac848fba3b6674ec8f2426c2025-02-03T05:44:09ZengWileyJournal of Immunology Research2314-88612314-71562021-01-01202110.1155/2021/99190249919024Inflamm-Aging-Related Cytokines of IL-17 and IFN-γ Accelerate Osteoclastogenesis and Periodontal DestructionJingyi Tan0Anna Dai1Lai Pan2Lan Zhang3Zhongxiu Wang4Ting Ke5Weilian Sun6Yanmin Wu7Pei-Hui Ding8Lili Chen9Department of Periodontology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310009, ChinaStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, Zhejiang 310006, ChinaDepartment of Periodontology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310009, ChinaStomatology Department, Zhejiang Hospital, Hangzhou 310007, ChinaDepartment of Periodontology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310009, ChinaDepartment of Periodontology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310009, ChinaDepartment of Periodontology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310009, ChinaDepartment of Periodontology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310009, ChinaStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Clinical Research Center for Oral Diseases of Zhejiang Province, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, Zhejiang 310006, ChinaDepartment of Periodontology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou 310009, ChinaPeriodontal disease (PD), as an age-related disease, prevalent in middle-aged and elderly population, is characterized as inflammatory periodontal tissue loss, including gingival inflammation and alveolar bone resorption. However, the definite mechanism of aging-related inflammation in PD pathology needs further investigation. Our study is aimed at exploring the effect of inflamm-aging-related cytokines of interleukin-17 (IL-17) and interferon-γ (IFN-γ) on osteoclastogenesis in vitro and periodontal destruction in vivo. For receptor activator of nuclear factor-κB ligand- (RANKL-) primed bone marrow macrophages (BMMs), IL-17 and IFN-γ enhanced osteoclastogenesis, with the expression of osteoclastogenic mRNA (TRAP, c-Fos, MMP-9, Ctsk, and NFATc1) and protein (c-Fos and MMP-9) upregulated. Ligament-induced rat models were established to investigate the role of IL-17 and IFN-γ on experimental periodontitis. Both IL-17 and IFN-γ could enhance the local inflammation in gingival tissues. Although there might be an antagonistic interaction between IL-17 and IFN-γ, IL-17 and IFN-γ could facilitate alveolar bone loss and osteoclast differentiation.http://dx.doi.org/10.1155/2021/9919024 |
| spellingShingle | Jingyi Tan Anna Dai Lai Pan Lan Zhang Zhongxiu Wang Ting Ke Weilian Sun Yanmin Wu Pei-Hui Ding Lili Chen Inflamm-Aging-Related Cytokines of IL-17 and IFN-γ Accelerate Osteoclastogenesis and Periodontal Destruction Journal of Immunology Research |
| title | Inflamm-Aging-Related Cytokines of IL-17 and IFN-γ Accelerate Osteoclastogenesis and Periodontal Destruction |
| title_full | Inflamm-Aging-Related Cytokines of IL-17 and IFN-γ Accelerate Osteoclastogenesis and Periodontal Destruction |
| title_fullStr | Inflamm-Aging-Related Cytokines of IL-17 and IFN-γ Accelerate Osteoclastogenesis and Periodontal Destruction |
| title_full_unstemmed | Inflamm-Aging-Related Cytokines of IL-17 and IFN-γ Accelerate Osteoclastogenesis and Periodontal Destruction |
| title_short | Inflamm-Aging-Related Cytokines of IL-17 and IFN-γ Accelerate Osteoclastogenesis and Periodontal Destruction |
| title_sort | inflamm aging related cytokines of il 17 and ifn γ accelerate osteoclastogenesis and periodontal destruction |
| url | http://dx.doi.org/10.1155/2021/9919024 |
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