Mechanism of action of the nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome and its regulation in liver injury

Mechanism of action of the nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome and its regulation in liver injury

Abstract. Nucleotide-binding oligomerization domain (NOD)-like receptor protein 3 (NLRP3) is a cytosolic pattern recognition receptor that recognizes multiple pathogen-associated molecular patterns and damage-associated molecular patterns. It is a cytoplasmic immune factor that responds to cellular...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yifan Lu, Tianyu Wang, Bo Yu, Kang Xia, Jiayu Guo, Yiting Liu, Xiaoxiong Ma, Long Zhang, Jilin Zou, Zhongbao Chen, Jiangqiao Zhou, Tao Qiu, Yanjie Yin
Format:	Article
Language:	English
Published:	Wolters Kluwer 2025-05-01
Series:	Chinese Medical Journal
Online Access:	http://journals.lww.com/10.1097/CM9.0000000000003309
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Impeding Nucleotide‐Binding Oligomerization Domain‐Like Receptor 3 Inflammasome Ameliorates Cardiac Remodeling and Dysfunction in Obesity‐Associated Cardiomyopathy
by: Shi‐qiang Liu, et al.
Published: (2024-12-01)

Intranasal Application of Budesonide Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Suppressing Nucleotide-Binding Oligomerization Domain-Like Receptor Family, Pyrin Domain-Containing 3 Inflammasome Activation in Mice
by: Liang Dong, et al.
Published: (2019-01-01)

Nucleotide-binding oligomerization domain 1 (NOD1) regulates microglial activation in pseudorabies virus infection
by: Xiuxiu Sun, et al.
Published: (2024-12-01)

Signaling Pathway of Nucleotide-Binding Oligomerization Domain-Containing Protein 1 and Potential Therapeutic Targets for Regulating the Gut Microbiota of Individuals with Gallstone Disease
by: Sanjana Murali, et al.
Published: (2025-01-01)

NOD2 (Nucleotide-Binding Oligomerization Domain-Containing Protein 2)-Mediated Modulation of the Immune Response Induced by BCG (Bacillus Calmette-Guérin) Bacilli
by: Magdalena Jurczak, et al.
Published: (2025-07-01)

Distinct oligomeric assemblies of STING induced by non-nucleotide agonists
by: Anant Gharpure, et al.
Published: (2025-04-01)

Nucleotide-Bound Oligomeric Domain-Like Receptor Protein 3 as a Serological Biomarker in Relation to Disease Severity and Delirium After Acute Pancreatitis: A Two-Center Prospective Cohort Study
by: Tang Z, et al.
Published: (2025-06-01)

Nucleotide-induced hyper-oligomerization inactivates transcription termination factor ρ
by: Bing Wang, et al.
Published: (2025-02-01)

Genomic organization, domain assortments, and nucleotide-binding domain diversity of NLR proteins in Sordariales fungi.
by: Lucas Bonometti, et al.
Published: (2025-07-01)

Transmembrane DomainDependent Functional Oligomerization of Syndecans
by: Jae Youn Yi, et al.
Published: (2006-01-01)

Graft survival after percutaneous transluminal renal stenting for transplant renal artery stenosis (TRAS) is worse compared to matched cadaveric grafts without TRAS
by: Long Zhang, et al.
Published: (2024-12-01)

Mechanism of ATP hydrolysis in the Hsp70 BiP nucleotide-binding domain
by: Guillaume Mas, et al.
Published: (2025-06-01)

Dopamine transporter oligomerization involves the scaffold domain, but spares the bundle domain.
by: Kumaresan Jayaraman, et al.
Published: (2018-06-01)

Influence of nonenzymatic posttranslational modifications on constitution, oligomerization and receptor binding of S100A12.
by: Kerstin Augner, et al.
Published: (2014-01-01)

Identification of synaptosomal proteins binding to monomeric and oligomeric α-synuclein.
by: Cristine Betzer, et al.
Published: (2015-01-01)

Thermodynamic Coupling between Folding Correctors and the First of Dimerized Nucleotide Binding Domains in CFTR
by: Guangyu Wang
Published: (2025-07-01)

T cell responses induced by adenoviral vectored vaccines can be adjuvanted by fusion of antigen to the oligomerization domain of C4b-binding protein.
by: Emily K Forbes, et al.
Published: (2012-01-01)

A Novel Protein Interaction between Nucleotide Binding Domain of Hsp70 and p53 Motif
by: Asita Elengoe, et al.
Published: (2015-01-01)

A Kinetic Model of Antigen‐Dependent IgG Oligomerization and Complement Binding
by: Jürgen Strasser, et al.
Published: (2025-07-01)

Lysyl hydroxylase 3 modifies lysine residues to facilitate oligomerization of mannan-binding lectin.
by: Maija Risteli, et al.
Published: (2014-01-01)

The interdomain linker of AAV-2 Rep68 is an integral part of its oligomerization domain: role of a conserved SF3 helicase residue in oligomerization.
by: Francisco Zarate-Perez, et al.
Published: (2012-01-01)

ATP‐Dependent Thermo‐Ring Basis for the Heat Unfolding of the First Nucleotide‐Binding Domain Isolated From Human CFTR
by: Guangyu Wang
Published: (2025-04-01)

A Nucleotide-Binding Domain Leucine-Rich Repeat Gene Regulates Plant Growth and Defense Against Chewing Herbivores
by: Chen Qiu, et al.
Published: (2024-11-01)

Activation of Toll-Like Receptors and Inflammasome Complexes in the Diabetic Cardiomyopathy-Associated Inflammation
by: J. Fuentes-Antrás, et al.
Published: (2014-01-01)

The Emerging Role of Colchicine to Inhibit NOD-like Receptor Family, Pyrin Domain Containing 3 Inflammasome and Interleukin-1β Expression in In Vitro Models
by: Tri Astiawati, et al.
Published: (2025-03-01)

Nucleotide binding switches the information flow in ras GTPases.
by: Francesco Raimondi, et al.
Published: (2011-03-01)

Generalized oligomeric system
by: V. M. Komarov, et al.
Published: (2008-08-01)

Binding Specificity and Oligomerization of TSWV N Protein in the Western Flower Thrips, <i>Frankliniella occidentalis</i>
by: Falguni Khan, et al.
Published: (2025-06-01)

HSV1 glycoprotein D utilizes an LY6-like binding domain to inhibit alpha7 nicotinic receptors
by: Sabina Yeasmin, et al.
Published: (2025-06-01)

Dact1 induces Dishevelled oligomerization to facilitate binding partner switch and signalosome formation during convergent extension
by: Allyson Angermeier, et al.
Published: (2025-03-01)

Neutrophil elastase binds at the central domain of extracellular Toll-like receptor 4: AI prediction, docking, and validation in disease model
by: Azeem Ali, et al.
Published: (2025-03-01)

Chlamydial entry involves TARP binding of guanine nucleotide exchange factors.
by: B Josh Lane, et al.
Published: (2008-03-01)

The strand exchange domain of tumor suppressor PALB2 is intrinsically disordered and promotes oligomerization-dependent DNA compaction
by: Yevhenii Kyriukha, et al.
Published: (2024-12-01)

Hippocampal NLRP1 inflammasome mediates anxiety-like behavior in mice with hypothyroidism
by: Yu-Wei Cheng, et al.
Published: (2025-05-01)

The impact of donor diabetes on recipient postoperative complications, renal function, and survival rate in deceased donor kidney transplantation: a single-center analysis
by: Qi Chen, et al.
Published: (2024-12-01)

Association of Toll-Like Receptor 3 Single-Nucleotide Polymorphisms and Hepatitis C Virus Infection
by: Mashael R. Al-Anazi, et al.
Published: (2017-01-01)

Replacing protruding domains of MrNV virus-like particles with sialic acid binding domains enhances binding to SARS-CoV-2 susceptible cells and reduces pseudovirus infection
by: Supawich Boonkua, et al.
Published: (2025-07-01)

Calcium-dependent oligomerization of scavenger receptor CD163 facilitates the endocytosis of ligands
by: Hua Xu, et al.
Published: (2025-07-01)

Structural aspects of nucleotide ligand binding by a bacterial 2H phosphoesterase.
by: Matti Myllykoski, et al.
Published: (2017-01-01)

Single Nucleotide Polymorphisms in MicroRNA Binding Sites: Implications in Colorectal Cancer
by: Panchalee Bhaumik, et al.
Published: (2014-01-01)