Treatment advances in Vitiligo: An Updated Review
Introduction Vitiligo is a common disorder of depigmentation caused by the progressive destruction of melanocytes that affects the skin, hair, and mucous membranes, clinically presenting as depigmented macules and leukotrichia. This condition, affecting millions of people worldwide, has a signifi...
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Mattioli1885
2025-01-01
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| Series: | Dermatology Practical & Conceptual |
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| Online Access: | https://dpcj.org/index.php/dpc/article/view/4600 |
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| author | Ishrat Binti Ismail Yasmeen Jabeen Bhat Mohd Shurjeel ul Islam |
| author_facet | Ishrat Binti Ismail Yasmeen Jabeen Bhat Mohd Shurjeel ul Islam |
| author_sort | Ishrat Binti Ismail |
| collection | DOAJ |
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Introduction
Vitiligo is a common disorder of depigmentation caused by the progressive destruction of melanocytes that affects the skin, hair, and mucous membranes, clinically presenting as depigmented macules and leukotrichia. This condition, affecting millions of people worldwide, has a significant psychosocial burden on patients’ quality of life, particularly in relation to skin colour. The etiopathogenesis of this disorder is obscure, but multiple factors contribute to the loss of melanocytes in the skin, like oxidative stress, inflammation, genetics, and autoimmunity. The treatment of vitiligo has been challenging over the past years, but recent developments in understanding the etiopathogenesis of the disease have paved the way for the development of more effective and promising therapeutic treatment options.
Objective
The aim of this review was to provide an overview of the underlying mechanisms and highlight the latest advances in the treatment of vitiligo.
Methodology
This review was performed according to PRISMA (Preferred Reporting Items for Systematic Reviews and Metanalyses) guidelines. A comprehensive search of the literature was carried out through the PubMed electronic database from inception to 31 December 2023 using the following search terms “vitiligo” AND “JAK inhibitors”, “vitiligo” AND “prostaglandin”, “vitiligo” AND “afamelanotide”, “vitiligo” AND “antioxidants”, “vitiligo” AND “vitamin D3”, “vitiligo AND “statins”, “vitiligo” AND “TNF-alpha”, “vitiligo” AND “interleukin”, “vitiligo” AND “light therapy”. Two independent reviewers screened titles, abstracts, and full texts to select papers dealing with vitiligo and its treatment.
Conclusion
The advent of treatment modalities like Janus kinase inhibitors, prostaglandin analogues, antioxidants, TNF-α inhibitors, targeted phototherapy, and excimer lasers has revolutionized the therapeutic possibilities, offering a ray of hope to the individuals suffering from this devastating condition.
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| format | Article |
| id | doaj-art-004b468659cf40a49499f2f3ec9b2f4b |
| institution | Kabale University |
| issn | 2160-9381 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Mattioli1885 |
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| series | Dermatology Practical & Conceptual |
| spelling | doaj-art-004b468659cf40a49499f2f3ec9b2f4b2025-02-04T15:41:41ZengMattioli1885Dermatology Practical & Conceptual2160-93812025-01-0115110.5826/dpc.1501a4600Treatment advances in Vitiligo: An Updated ReviewIshrat Binti Ismail0Yasmeen Jabeen Bhat1https://orcid.org/0000-0001-5171-6832Mohd Shurjeel ul Islam2Department of dermatology venereology and leprosy GMC Srinagar Department of dermatology venereology and leprosy GMC Srinagar Department of dermatology venereology and leprosy GMC Srinagar Introduction Vitiligo is a common disorder of depigmentation caused by the progressive destruction of melanocytes that affects the skin, hair, and mucous membranes, clinically presenting as depigmented macules and leukotrichia. This condition, affecting millions of people worldwide, has a significant psychosocial burden on patients’ quality of life, particularly in relation to skin colour. The etiopathogenesis of this disorder is obscure, but multiple factors contribute to the loss of melanocytes in the skin, like oxidative stress, inflammation, genetics, and autoimmunity. The treatment of vitiligo has been challenging over the past years, but recent developments in understanding the etiopathogenesis of the disease have paved the way for the development of more effective and promising therapeutic treatment options. Objective The aim of this review was to provide an overview of the underlying mechanisms and highlight the latest advances in the treatment of vitiligo. Methodology This review was performed according to PRISMA (Preferred Reporting Items for Systematic Reviews and Metanalyses) guidelines. A comprehensive search of the literature was carried out through the PubMed electronic database from inception to 31 December 2023 using the following search terms “vitiligo” AND “JAK inhibitors”, “vitiligo” AND “prostaglandin”, “vitiligo” AND “afamelanotide”, “vitiligo” AND “antioxidants”, “vitiligo” AND “vitamin D3”, “vitiligo AND “statins”, “vitiligo” AND “TNF-alpha”, “vitiligo” AND “interleukin”, “vitiligo” AND “light therapy”. Two independent reviewers screened titles, abstracts, and full texts to select papers dealing with vitiligo and its treatment. Conclusion The advent of treatment modalities like Janus kinase inhibitors, prostaglandin analogues, antioxidants, TNF-α inhibitors, targeted phototherapy, and excimer lasers has revolutionized the therapeutic possibilities, offering a ray of hope to the individuals suffering from this devastating condition. https://dpcj.org/index.php/dpc/article/view/4600active vitiligojanus kinase inhibitorCXCL10 |
| spellingShingle | Ishrat Binti Ismail Yasmeen Jabeen Bhat Mohd Shurjeel ul Islam Treatment advances in Vitiligo: An Updated Review Dermatology Practical & Conceptual active vitiligo janus kinase inhibitor CXCL10 |
| title | Treatment advances in Vitiligo: An Updated Review |
| title_full | Treatment advances in Vitiligo: An Updated Review |
| title_fullStr | Treatment advances in Vitiligo: An Updated Review |
| title_full_unstemmed | Treatment advances in Vitiligo: An Updated Review |
| title_short | Treatment advances in Vitiligo: An Updated Review |
| title_sort | treatment advances in vitiligo an updated review |
| topic | active vitiligo janus kinase inhibitor CXCL10 |
| url | https://dpcj.org/index.php/dpc/article/view/4600 |
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